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First Contact Practitioners' (FCPs) and General Practitioners' Perceptions Towards FCPs Delivering Vocational Advice to Patients with Musculoskeletal Conditions: A Qualitative Investigation of the Implementation Potential of the I-SWAP Initiative. (2021)
Journal Article
Saunders, B., Foster, N. E., Hill, J. C., Sowden, G., Evans, N., Bishop, A., …Wynne-Jones, G. (2022). First Contact Practitioners' (FCPs) and General Practitioners' Perceptions Towards FCPs Delivering Vocational Advice to Patients with Musculoskeletal Conditions: A Qualitative Investigation of the Implementation Potential of the I-SWAP Initiative. Journal of Occupational Rehabilitation, 32, 147–155. https://doi.org/10.1007/s10926-021-09992-5

Purpose Musculoskeletal (MSK) pain is a common cause of work absence. The recent SWAP (Study of Work And Pain) randomised controlled trial (RCT) found that a brief vocational advice service for primary care patients with MSK pain led to fewer days' w... Read More about First Contact Practitioners' (FCPs) and General Practitioners' Perceptions Towards FCPs Delivering Vocational Advice to Patients with Musculoskeletal Conditions: A Qualitative Investigation of the Implementation Potential of the I-SWAP Initiative..

Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy (2021)
Journal Article
Bowerman. (2021). Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy. JCI insight, 1-24. https://doi.org/10.1172/jci.insight.149446

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify novel treatments to alleviate muscle pathology... Read More about Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020 (2021)
Journal Article
Mamas. (2021). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020

Background Deaths in the first year of the COVID-19 pandemic in England & Wales have been shown to be unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated as most measures of... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis. (2021)
Journal Article
(2021). Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis. PLoS Medicine, e1003686 - ?. https://doi.org/10.1371/journal.pmed.1003686

BACKGROUND: Timely interventions in women presenting with preterm labour can substantially improve health outcomes for preterm babies. However, establishing such a diagnosis is very challenging, as signs and symptoms of preterm labour are common and... Read More about Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis..

Oxygen desaturation and adverse outcomes in acute stroke: secondary analysis of the HeadPoST study (2021)
Journal Article
Roffe. (2021). Oxygen desaturation and adverse outcomes in acute stroke: secondary analysis of the HeadPoST study. Clinical Neurology and Neurosurgery, 106796 - 106796. https://doi.org/10.1016/j.clineuro.2021.106796

Objective: Uncertainty exists over the prognostic significance of low arterial oxygen saturation (SaO(2)) in acute stroke. We aimed to determine the strength of association of SaO(2) and adverse outcomes among participants of the international Head P... Read More about Oxygen desaturation and adverse outcomes in acute stroke: secondary analysis of the HeadPoST study.

Respiratory Disorders (2021)
Book Chapter
Gilchrist, F., & Carroll, W. D. (2021). Respiratory Disorders. In Illustrated Textbook of Paediatrics. (6th). Elsevier

This sixth edition of the acclaimed and award-winning ‘Sunflower book’ comprehensively covers the undergraduate curriculum in paediatrics and child health. Topics are made accessible with numerous colour images, diagrams and case studies, and revisio... Read More about Respiratory Disorders.

Chapter 17: Respiratory Disorders (2021)
Book Chapter
Gilchrist, F., & Carroll, W. (2021). Chapter 17: Respiratory Disorders. In Illustrated Textbook of Paediatrics, 6th Edition. Elsevier

Association between serum secretory phospholipase A2 and risk of ischemic stroke. (2021)
Journal Article
Mamas. (2021). Association between serum secretory phospholipase A2 and risk of ischemic stroke. European Journal of Neurology, https://doi.org/10.1111/ene.15004

BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been... Read More about Association between serum secretory phospholipase A2 and risk of ischemic stroke..

Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty (2021)
Journal Article
Chan, C. L., Taljaard, M., Lancaster, G. A., Brehaut, J. C., & Eldridge, S. M. (2021). Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty. Journal of Clinical Epidemiology, 138, 102-114. https://doi.org/10.1016/j.jclinepi.2021.06.029

Background and objective Feasibility studies are increasingly being used to support the development of, and investigate uncertainties around, future large-scale trials. The future trial can be designed with either a pragmatic or explanatory mindset.... Read More about Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty.

The development and validation of a prognostic model to PREDICT Relapse of depression in adult patients in primary care: protocol for the PREDICTR study. (2021)
Journal Article
Chew-Graham. (2021). The development and validation of a prognostic model to PREDICT Relapse of depression in adult patients in primary care: protocol for the PREDICTR study. Diagnostic and Prognostic Research, 12 - ?. https://doi.org/10.1186/s41512-021-00101-x

BACKGROUND: Most patients who present with depression are treated in primary care by general practitioners (GPs). Relapse of depression is common (at least 50% of patients treated for depression will relapse after a single episode) and leads to consi... Read More about The development and validation of a prognostic model to PREDICT Relapse of depression in adult patients in primary care: protocol for the PREDICTR study..

Effectiveness of stratified treatment for back pain in Danish primary care: A randomized controlled trial (2021)
Journal Article
Morsø, L., Olsen Rose, K., Schiøttz‐Christensen, B., Sowden, G., Søndergaard, J., & Christiansen, D. H. (2021). Effectiveness of stratified treatment for back pain in Danish primary care: A randomized controlled trial. European Journal of Pain, 25(9), 2020-2038. https://doi.org/10.1002/ejp.1818

Background A randomized controlled trial (RCT) of stratified care demonstrated superior clinical outcomes and cost-effectiveness for low back pain (LBP) patients in UK primary care. This is the first study in Europe, outside of the original UK study,... Read More about Effectiveness of stratified treatment for back pain in Danish primary care: A randomized controlled trial.

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (2021)
Journal Article
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., …Investigators, I. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. The Lancet Rheumatology, 3(7), e498 - e506. https://doi.org/10.1016/s2665-9913%2821%2900104-1

Background Early in the pandemic it was suggested that pre-existing use of non-steroidal anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with COVID-19. NSAIDs are an important analgesic, particularly in those wit... Read More about Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (2021)
Journal Article
Docherty, A. B., Mulholland, R. H., Lone, N. I., Cheyne, C. P., De Angelis, D., Diaz-Ordaz, K., …Investigators, I. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. Lancet Respiratory Medicine, 9(7), 773 - 785. https://doi.org/10.1016/s2213-2600%2821%2900175-2

Background Mortality rates in hospitalised patients with COVID-19 in the UK appeared to decline during the first wave of the pandemic. We aimed to quantify potential drivers of this change and identify groups of patients who remain at high risk of dy... Read More about Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK.

Risk-mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey. (2021)
Journal Article
Mahil, S., Yates, M., Langan, S., Yiu, Z., Tsakok, T., Dand, N., …study groups, P. C. (2021). Risk-mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey. British Journal of Dermatology, 185(1), https://doi.org/10.1111/bjd.19755

BACKGROUND: Registry data suggest that people with immune-mediated inflammatory diseases (IMIDs) receiving targeted systemic therapies have fewer adverse coronavirus disease 2019 (COVID-19) outcomes compared with patients receiving no systemic treatm... Read More about Risk-mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey..

Educational programmes for frail older people, their families, carers, and healthcare professionals: A Systematic Review. (2021)
Journal Article
Viggars, R., Finney, A., & Panayiotou, B. (2021). Educational programmes for frail older people, their families, carers, and healthcare professionals: A Systematic Review. Central European Journal of Medicine, https://doi.org/10.1007/s00508-021-01900-4

Purpose: More people are living with frailty and requiring additional health and support services. To improve their management, the ‘Frailty: Core Capability Framework’ in the United Kingdom recommends frailty education for older individuals, their f... Read More about Educational programmes for frail older people, their families, carers, and healthcare professionals: A Systematic Review..

What Will It Mean for Me? Perceptions of the ECFMG 2023 Accreditation Requirement from an Online Forum (2021)
Journal Article
Arfeen, Z., Mughal, F., Ahmed Rashid, M., Smith, V., & Tackett, S. (2021). What Will It Mean for Me? Perceptions of the ECFMG 2023 Accreditation Requirement from an Online Forum. https://doi.org/10.30770/2572-1852-107.2.49

ABSTRACT In 2010, the Educational Commission for Foreign Medical Graduates (ECFMG) announced that as of 2023, physicians applying to train and practice in the United States will be required to graduate from a medical school that has been accredited u... Read More about What Will It Mean for Me? Perceptions of the ECFMG 2023 Accreditation Requirement from an Online Forum.