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All Outputs (633)

Sex Differences in Outcomes Following Left Atrial Appendage Closure. (2021)
Journal Article
Sanjoy, S. S., Choi, Y., Sparrow, R. T., Baron, S. J., Abbott, J. D., Azzalini, L., …Bagur, R. (2021). Sex Differences in Outcomes Following Left Atrial Appendage Closure. https://doi.org/10.1016/j.mayocp.2020.11.031

OBJECTIVE: To evaluate the effects of female sex on in-hospital outcomes and to provide estimates for sex-specific prediction models of adverse outcomes following left atrial appendage closure (LAAC). PATIENTS AND METHODS: Cohort-based observational... Read More about Sex Differences in Outcomes Following Left Atrial Appendage Closure..

Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Zghouzi, M., Suleiman, A. M., Attique, H., Ullah, W., …Alraies, M. C. (2021). Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. High Blood Pressure and Cardiovascular Prevention, 405 - 416. https://doi.org/10.1007/s40292-021-00462-w

INTRODUCTION: The safety of renin-angiotensin-aldosterone system inhibitors (RAASi) among COVID-19 patients has been controversial since the onset of the pandemic. METHODS: Digital databases were queried to study the safety of RAASi in COVID-19. The... Read More about Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population..

Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.03.057

Chronic kidney disease (CKD) in patients with ST-elevation myocardial infarction (STEMI) is associated with worse outcomes. We assessed the impact of CKD on guideline directed coronary revascularization and outcomes among STEMI patients. The Nationwi... Read More about Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction..

Peer mentorship to improve self-management of hip and knee osteoarthritis: a randomised feasibility trial (2021)
Journal Article
Anderson, A. M., Lavender, E. C., Dusabe-Richards, E., Mebrahtu, T. F., McGowan, L., Conaghan, P. G., …McHugh, G. A. (2021). Peer mentorship to improve self-management of hip and knee osteoarthritis: a randomised feasibility trial. BMJ Open, e045389 - e045389. https://doi.org/10.1136/bmjopen-2020-045389

Objective To determine the feasibility of conducting a randomised controlled trial (RCT) of a peer mentorship intervention to improve self-management of osteoarthritis (OA). Design Six-month parallel group non-blinded randomised feasibility trial.... Read More about Peer mentorship to improve self-management of hip and knee osteoarthritis: a randomised feasibility trial.

Prognostic biomarkers to identify patients likely to develop severe Crohn’s disease: a systematic review (2021)
Journal Article
Halligan, S., Boone, D., Archer, L., Ahmad, T., Bloom, S., Rodriguez-Justo, M., …Mallett, S. (2021). Prognostic biomarkers to identify patients likely to develop severe Crohn’s disease: a systematic review. Health Technology Assessment, 25(45), 1-66. https://doi.org/10.3310/hta25450

BACKGROUND: Identification of biomarkers that predict severe Crohn's disease is an urgent unmet research need, but existing research is piecemeal and haphazard. OBJECTIVE: To identify biomarkers that are potentially able to predict the development of... Read More about Prognostic biomarkers to identify patients likely to develop severe Crohn’s disease: a systematic review.

Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study (2021)
Thesis
Mughal, F. H. (2021). Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study. (Thesis). Keele University

Self-harm in young people is a national priority. General practitioners see young people who self-harm the most often in the National Health Service (NHS), and episodes of self-harm in young people presenting to general practice are rising. General p... Read More about Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study.

Treatment targets and outcomes in randomised controlled trials of exercise for non-specific low back pain (2021)
Thesis
Wood, L. (2021). Treatment targets and outcomes in randomised controlled trials of exercise for non-specific low back pain. (Thesis). Keele University

Persistent non-specific low back pain (NSLBP) is the leading cause of years lived with disability globally, and exercise is the most widely recommended treatment for persistent NSLBP. Previous randomised controlled trials (RCTs) tend to conclude that... Read More about Treatment targets and outcomes in randomised controlled trials of exercise for non-specific low back pain.

Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study (2021)
Thesis
Abhayasinghe, M. P. K. W. (2021). Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study. (Thesis). Keele University

Introduction: Dementia is a global health concern affecting an estimated 115.4 million people. Dementia has become a research priority in low-and-middle income countries (LAMIC), due to increasing prevalence associated with demographic transition an... Read More about Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study.

Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study (2021)
Thesis
Birkinshaw, H. (2021). Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study. (Thesis). Keele University

Introduction Musculoskeletal pain is common in older adults (aged =65), but current assessment and management in primary care is suboptimal. Prognostic stratified care matches treatment options to patients based upon their risk of persistent pain si... Read More about Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study.

Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records (2021)
Thesis
Rathod-Mistry, T. (2021). Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records. (Thesis). Keele University

Background Primary care electronic health records (EHR) capture real life patterns of healthcare utilisation over time. This provides the opportunity to estimate the effect of allopurinol on long term outcomes in people with gout. However, use of su... Read More about Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records.

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. (2021)
Journal Article
Davies, & Lambie. (2021). A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. Kidney International, 1101-1111. https://doi.org/10.1016/j.kint.2021.05.037

Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that com... Read More about A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis..

Progression from external pilot to definitive randomised controlled trial: a methodological review of progression criteria reporting. (2021)
Journal Article
(2021). Progression from external pilot to definitive randomised controlled trial: a methodological review of progression criteria reporting. BMJ Open, e048178 - ?. https://doi.org/10.1136/bmjopen-2020-048178

OBJECTIVES: Prespecified progression criteria can inform the decision to progress from an external randomised pilot trial to a definitive randomised controlled trial. We assessed the characteristics of progression criteria reported in external random... Read More about Progression from external pilot to definitive randomised controlled trial: a methodological review of progression criteria reporting..

The XGTDL family of survival distributions (2021)
Journal Article
Bucknall. (2021). The XGTDL family of survival distributions. Japanese Journal of Statistics and Data Science, https://doi.org/10.1007/s42081-021-00129-9

AbstractNon-PH parametric survival modelling is developed within the framework of the multiple logistic function. The family considered comprises three basic models: (a) a PH model, (b) an accelerated life model and (c) a model which is non-proportio... Read More about The XGTDL family of survival distributions.

Protective factors and sources of support in the workplace as experienced by UK foundation and junior doctors: a qualitative study (2021)
Journal Article
Chew-Graham. (2021). Protective factors and sources of support in the workplace as experienced by UK foundation and junior doctors: a qualitative study. BMJ Open, e045588 -?. https://doi.org/10.1136/bmjopen-2020-045588

OBJECTIVES: This paper reports findings identifying foundation and junior doctors' experiences of occupational and psychological protective factors in the workplace and sources of effective support. DESIGN: Interpretative, inductive, qualitative stud... Read More about Protective factors and sources of support in the workplace as experienced by UK foundation and junior doctors: a qualitative study.

In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease (2021)
Journal Article
Zghouzi, M., Moussa Pacha, H., Ullah, W., Sattar, Y., Ahmad, B., Osman, H., …Alraies, M. C. (in press). In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, 98(4), https://doi.org/10.1002/ccd.29827

Background The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. Methods Using the National Inpatient Sample datab... Read More about In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease.

Sources of work-related psychological distress experienced by UK-wide foundation and junior doctors: a qualitative study. (2021)
Journal Article
Chew-Graham. (2021). Sources of work-related psychological distress experienced by UK-wide foundation and junior doctors: a qualitative study. BMJ Open, https://doi.org/10.1136/bmjopen-2020-043521

OBJECTIVES: This paper reports findings exploring work cultures, contexts and conditions associated with psychological distress in foundation and junior doctors. DESIGN: Qualitative study using in-depth interviews with 21 junior doctor participants.... Read More about Sources of work-related psychological distress experienced by UK-wide foundation and junior doctors: a qualitative study..

Dystrophin regulates peripheral circadian SRF signalling (2021)
Other
Betts, C. A., Jagannath, A., van Westering, T. L., Bowerman, M., Banerjee, S., Meng, J., …Wood, M. J. (2021). Dystrophin regulates peripheral circadian SRF signalling

Dystrophin is a sarcolemmal protein essential for muscle contraction and maintenance, absence of which leads to the devastating muscle wasting disease Duchenne muscular dystrophy (DMD)[1, 2]. Dystrophin has an actin-binding domain [3–5], which specif... Read More about Dystrophin regulates peripheral circadian SRF signalling.

Can We Prevent Depression in At-Risk Older Adults Using Self-Help? The UK SHARD Trial of Behavioral Activation. (2021)
Journal Article
Chew-Graham. (2021). Can We Prevent Depression in At-Risk Older Adults Using Self-Help? The UK SHARD Trial of Behavioral Activation. American Journal of Geriatric Psychiatry, 197-207. https://doi.org/10.1016/j.jagp.2021.06.006

BACKGROUND: Treatment of established depression is the dominant approach to care of older adults, but prevention holds much promise. Self-help interventions are a feasible preventive approach, since they are scalable and low cost. There are few trial... Read More about Can We Prevent Depression in At-Risk Older Adults Using Self-Help? The UK SHARD Trial of Behavioral Activation..