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Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..

Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial (2021)
Journal Article
Allison, K., Jones, S., Hinman, R. S., Briggs, A. M., Sumithran, P., Quicke, J., …Bennell, K. (2021). Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial. Arthritis Care and Research, 75(4), 835-847. https://doi.org/10.1002/acr.24828

OBJECTIVE: Evaluate effects of an online education program about weight management for osteoarthritis on physiotherapists' self-reported confidence in knowledge and skills in weight management, and attitudes toward obesity. METHOD: A two-group ran... Read More about Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial.

Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. (2021)
Journal Article
Mamas. (2021). Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation. The American Journal of Cardiology, 58 - 64. https://doi.org/10.1016/j.amjcard.2021.11.021

To compare the efficacy and safety of apixaban and rivaroxaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) by way of a meta-analysis informed by real-world evidence. Systematic review and meta-analysis of obse... Read More about Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation..

In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. (2021)
Journal Article
Mamas. (2021). In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer. The American Journal of Cardiology, 25 - 37. https://doi.org/10.1016/j.amjcard.2021.11.015

There are limited data on readmission with ischemic and major bleeding events in patients with acute myocardial infarction (AMI) with active cancer. The purpose of our study was to evaluate in-hospital characteristics and 30-day readmission rates for... Read More about In-Hospital Characteristics and 30-Day Readmissions for Acute Myocardial Infarction and Major Bleeding in Patients With Active Cancer..

Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study (2021)
Journal Article
(2021). Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study. JMIR Research Protocols, e19543 - e19543

Background There is a growing interest in using mobile apps to support communication, safety, and well-being. Evidence directly from people with dementia regarding the usability, usefulness, and relevance of mobile apps is limited. Objective This... Read More about Co-designing an Adaption of a Mobile App to Enhance Communication, Safety, and Well-being Among People Living at Home With Early-Stage Dementia: Protocol for an Exploratory Multiple Case Study.

Acceptability of physician associate interns in primary care: results from a service evaluation. (2021)
Journal Article
Lawton, & Silverwood. (2021). Acceptability of physician associate interns in primary care: results from a service evaluation. BMC Family Practice, 250 - ?. https://doi.org/10.1186/s12875-021-01372-5

BACKGROUND: Physician associates (PA) form part of the policy-driven response to increased primary care demand and a general practitioner (GP) recruitment and retention crisis. However, they are novel to the primary care workforce and have limitation... Read More about Acceptability of physician associate interns in primary care: results from a service evaluation..

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., …Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder. AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

IS INTRAVENOUS ASPIRIN SAFE FOR EMERGENT STENTING IN THROMBOLYSED PATIENTS TREATED BY MECHANICAL THROMBECTOMY? (2021)
Journal Article
Ingleton, A., Raseta, M., & Roffe, C. (2021). IS INTRAVENOUS ASPIRIN SAFE FOR EMERGENT STENTING IN THROMBOLYSED PATIENTS TREATED BY MECHANICAL THROMBECTOMY?. International Journal of Stroke, 16(3),

Introduction: Intraoperative stenting is used during mechanical thrombectomy (MT) to manage severe stenosis or dissection. Antiplatelet agents are required intraoperatively to maintain patency of the stent. However, antiplatelets are contraindicated... Read More about IS INTRAVENOUS ASPIRIN SAFE FOR EMERGENT STENTING IN THROMBOLYSED PATIENTS TREATED BY MECHANICAL THROMBECTOMY?.

Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models. (2021)
Journal Article
(2021). Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models. International Journal of Epidemiology, 615-625. https://doi.org/10.1093/ije/dyab256

BACKGROUND: External validation of prognostic models is necessary to assess the accuracy and generalizability of the model to new patients. If models are validated in a setting in which competing events occur, these competing risks should be accounte... Read More about Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models..

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., …Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. (2021)
Journal Article
Mamas. (2021). Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circulation: Heart Failure, e008685 - ?. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685

BACKGROUND: Heart failure has a disproportionate burden on patients who are Black, Indigenous, and people of color (BIPOC), but not much is known about representation of these groups in randomized controlled trials (RCTs). We explored temporal trends... Read More about Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review..

Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome. (2021)
Journal Article
Riley, R. D., Collins, G. S., Ensor, J., Archer, L., Booth, S., Mozumder, S. I., …Snell, K. I. E. (2022). Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome. Statistics in Medicine, 41(7), 1280-1295. https://doi.org/10.1002/sim.9275

Previous articles in Statistics in Medicine describe how to calculate the sample size required for external validation of prediction models with continuous and binary outcomes. The minimum sample size criteria aim to ensure precise estimation of key... Read More about Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome..

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021)
Journal Article
de Leon, J., Schoretsanitis, G., Smith, R. L., Molden, E., Solismaa, A., Seppälä, N., …Marder, S. R. (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry, 55(02), 73-86. https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and... Read More about An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study (2021)
Journal Article
Musgrove, R., Carr, M., Chew-Graham, C., Mughal, F., Kapur, N., Ashcroft, D., & Webb, R. (2021). Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study. British Journal of Psychiatry, 1 - 8. https://doi.org/10.1192/bjp.2021.176

Background Evidence for risk of dying by suicide and other causes following discharge from in-patient psychiatric care throughout adulthood is sparse. Aims To estimate risks of all-cause mortality, natural and external-cause deaths, suicide and ac... Read More about Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study.

What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study. (2021)
Journal Article
Chew-Graham. (2021). What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study. BMJ Open, e056122 - ?. https://doi.org/10.1136/bmjopen-2021-056122

OBJECTIVES: This paper reports findings exploring junior doctors' experiences of working during the COVID-19 pandemic in the UK. DESIGN: Qualitative study using in-depth interviews with 15 junior doctors. Interviews were audio-recorded, transcribed,... Read More about What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study..

Exploring Specialist Palliative Care Practitioner Perspectives on the Face Validity of the Attitude to Health Change Scales in Assessing the Impact of Life-limiting Illness on Patients and Carers (2021)
Journal Article
Machin, L., Walshe, C., & Dunleavy, L. (2021). Exploring Specialist Palliative Care Practitioner Perspectives on the Face Validity of the Attitude to Health Change Scales in Assessing the Impact of Life-limiting Illness on Patients and Carers. Journal of Palliative Care, 39(3), 175-183. https://doi.org/10.1177/08258597211064016

Background: Identifying and assessing vulnerability and resilience through reflexive reactions and conscious coping responses to life-limiting illness is an important, but rarely assessed, component of care. The novel Attitude to Health Change scales... Read More about Exploring Specialist Palliative Care Practitioner Perspectives on the Face Validity of the Attitude to Health Change Scales in Assessing the Impact of Life-limiting Illness on Patients and Carers.

Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study (2021)
Journal Article
Rashid, Mamas, & Nolan. (2021). Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study. European Journal of Preventive Cardiology, 1084-1092. https://doi.org/10.1093/eurjpc/zwab200

Background: The importance of standard modifiable cardiovascular risk factors (SMuRFs) in preventing non-ST segment myocardial infarction (NSTEMI) is established. However, NSTEMI may present in the absence of SMuRFs, and little is known about their o... Read More about Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study.

Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs. (2021)
Journal Article
Yeates, P., Moult, A., Cope, N., McCray, G., Fuller, R., & McKinley, R. (2022). Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs. Medical Education, 56(3), 292-302. https://doi.org/10.1111/medu.14713

INTRODUCTION: Differential rater function over time (DRIFT) and contrast effects (examiners' scores biased away from the standard of preceding performances) both challenge the fairness of scoring in Objective Structured Clinical Exams (OSCEs). This i... Read More about Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs..