Skip to main content

Research Repository

Advanced Search

All Outputs (630)

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation (2021)
Journal Article
Fuchs, S., T. Garrood, W., Beber, A., Hammond, A., Galizi, R., Gribble, M., …Nolan, T. (2021). Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation. PLOS genetics, Article e1009740. https://doi.org/10.1371/journal.pgen.1009740

CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory. This class of gene drives relies on CRISPR-Cas9 cleavage of a target se... Read More about Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.

The identification of endometrial immune cell densities and clustering analysis in the mid-luteal phase as predictor for pregnancy outcomes after IVF-ET treatment (2021)
Journal Article
Zhao, Y., Man, G. C. W., Wang, J., Liu, Y., Kwong, J., Zhang, T., …Li, T. (2021). The identification of endometrial immune cell densities and clustering analysis in the mid-luteal phase as predictor for pregnancy outcomes after IVF-ET treatment. Journal of Reproductive Immunology, 148, Article ARTN 103431. https://doi.org/10.1016/j.jri.2021.103431

Changes in endometrial immune cell density has been reported to be associated with reproductive failure. The prognostic value of endometrial immune cell density measurement remains uncertain. We aimed to investigate the prognostic value of endometria... Read More about The identification of endometrial immune cell densities and clustering analysis in the mid-luteal phase as predictor for pregnancy outcomes after IVF-ET treatment.

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study (2021)
Journal Article
Collaborative*, C., & Parry-Smith, W. (2021). Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncology, 22(11), 1507-1517. https://doi.org/10.1016/S1470-2045%2821%2900493-9

Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery d... Read More about Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. (2021)
Journal Article
Kwong. (2021). Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. Biomedicines,

To investigate the role of DNA mismatch repair status (MMR) in survival of endometrioid endometrial cancer in Hong Kong Chinese women and its correlation to clinical prognostic factors, 238 patients with endometrioid endometrial cancer were included.... Read More about Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women..

Planned versus bailout rotational atherectomy: A systematic review and meta-analysis. (2021)
Journal Article
(2021). Planned versus bailout rotational atherectomy: A systematic review and meta-analysis

BACKGROUND/PURPOSE: Rotational atherectomy (RA) plays a central role in the treatment of heavily calcified coronary artery lesions. Our aim was to compare periprocedural characteristics and outcomes of planned (PA) vs. bailout (BA) rotational atherec... Read More about Planned versus bailout rotational atherectomy: A systematic review and meta-analysis..

The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients (2021)
Journal Article
Su, Y., Chen, Y., Tseng, Y., Shieh, G., Wu, P., Shiau, A., & Wu, C. (2021). The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients. Cells, 10(10), Article 2642. https://doi.org/10.3390/cells10102642

The embryonic stem cell marker Oct4 is expressed in several human cancers and is positively correlated with a poor outcome in cancer patients. However, its physiological role in cancer progression remains poorly understood. Tumor cells block apoptosi... Read More about The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients.

Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales (2021)
Journal Article
Mamas, & Rashid. (2021). Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales. https://doi.org/10.1016/j.cjco.2021.09.026

Background Studies of racial disparities in patients admitted with an OHCA in the setting of AMI have shown inconsistent results. Whether these differences in care exist in a universal healthcare system in England is unknown. Methods Patients admitte... Read More about Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales.

Reporting of prognostic clinical prediction models based on machine learning methods in oncology needs to be improved. (2021)
Journal Article
(2021). Reporting of prognostic clinical prediction models based on machine learning methods in oncology needs to be improved. Journal of Clinical Epidemiology, 60-72. https://doi.org/10.1016/j.jclinepi.2021.06.024

OBJECTIVE: Evaluate the completeness of reporting of prognostic prediction models developed using machine learning methods in the field of oncology. STUDY DESIGN AND SETTING: We conducted a systematic review, searching the MEDLINE and Embase database... Read More about Reporting of prognostic clinical prediction models based on machine learning methods in oncology needs to be improved..

Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. (2021)
Journal Article
Mamas. (2021). Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. European Heart Journal, 3844 - 3852. https://doi.org/10.1093/eurheartj/ehab444

AIMS: Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve e... Read More about Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial..

Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome. (2021)
Journal Article
(2021). Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome. https://doi.org/10.1016/j.amjcard.2021.06.042

There is limited data regarding the impact of time of admission on clinical outcomes of out of hospital cardiac arrest (OHCA) complicating acute myocardial infarction (AMI). We investigated the patient characteristics, management, and outcomes of OHC... Read More about Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome..

Managing chronic wet cough in children: another piece of the puzzle. (2021)
Journal Article
Gilchrist. (2021). Managing chronic wet cough in children: another piece of the puzzle. Lancet Respiratory Medicine, 1078 - 1079. https://doi.org/10.1016/S2213-2600%2821%2900159-4

Chronic wet cough is the hallmark of chronic obstructive pulmonary disease in older people and bronchiectasis in adults and older children. In young children, the commonest cause of chronic wet cough is protracted bacterial bronchitis (PBB) but there... Read More about Managing chronic wet cough in children: another piece of the puzzle..

In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. (2021)
Journal Article
Mamas. (2021). In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, E586 - E593. https://doi.org/10.1161/circinterventions.119.008150

BACKGROUND: The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. METHODS: Using the National Inpatient Sample database... Read More about In-hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease..

Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. (2021)
Journal Article
Mamas. (2021). Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. https://doi.org/10.1111/ijcp.14554

BACKGROUND: In recent years, there has been a growing interest in outcomes of patients with acute myocardial infarction (AMI) using large administrative datasets. The present study was designed to compare the characteristics, management strategies an... Read More about Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission..

Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach. (2021)
Journal Article
Lewis, M., & Hill, J. (2021). Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach. Musculoskeletal Science and Practice, 1- 10. https://doi.org/10.1016/j.msksp.2021.102415

BACKGROUND: At present there is no core outcome set (COS) for use in community and primary care Musculoskeletal (MSK) services across the UK. Services are therefore collecting different MSK outcomes and metrics in different ways and at different time... Read More about Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach..

Addressing conflicts of interest: evidence review and recommendations (2021)
Journal Article
Paskins. (2021). Addressing conflicts of interest: evidence review and recommendations. Medical Decision Making, https://doi.org/10.1177/0272989X211008881

Background More stringent policies for addressing conflicts of interest have been implemented around the world in recent years. Considering the value of revisiting conflict of interest quality standards set by the International Patient Decision Aid S... Read More about Addressing conflicts of interest: evidence review and recommendations.

Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. (2021)
Journal Article
Mamas. (2021). Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention. American Journal of Cardiology, 32 - 38. https://doi.org/10.1016/j.amjcard.2021.06.044

There are limited data on the outcomes of chronic liver disease (CLD) patients admitted for percutaneous coronary intervention (PCI). All PCI hospitalizations from the Nationwide Inpatient Sample (2004 to 2015) were analyzed and stratified by the pre... Read More about Comparison of Outcomes of Patients With Versus Without Chronic Liver Disease Undergoing Percutaneous Coronary Intervention..

835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study (2021)
Journal Article
Youssef, S., Zaidi, S., Lambie, M., & Ahmed, S. (2021). 835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study. British Journal of Surgery, 108(Supplement_6), https://doi.org/10.1093/bjs/znab259.876

Background UK academic foundation programme (AFP) is an important steppingstone into academic surgical training, but there is paucity in undergraduate preparedness. We aimed to evaluate the effectiveness of a virtual webinar series to prepare student... Read More about 835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study.