All Outputs (553)

The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap (2022)
Journal Article
Owen, S., Kline, R., Synowsky, S., Shirran, S., Sillence, K., Claus, P., …Holt, I. (2022). The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap. Cells, https://doi.org/10.3390/cells11172624

Most research to characterise the molecular consequences of spinal muscular atrophy (SMA) have focused on SMA I. Here, proteomic profiling of skin fibroblasts from severe (SMA I), intermediate (SMA II), and mild (SMA III) patients, alongside age-matc... Read More about The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap.

Relationship between working conditions and psychological distress experienced by junior doctors in the UK during the COVID-19 pandemic: a cross-sectional survey study. (2022)
Journal Article
Chew-Graham. (2022). Relationship between working conditions and psychological distress experienced by junior doctors in the UK during the COVID-19 pandemic: a cross-sectional survey study. BMJ Open, e061331 - ?. https://doi.org/10.1136/bmjopen-2022-061331

OBJECTIVES: This paper explored the self-reported prevalence of depression, anxiety and stress among junior doctors during the COVID-19 pandemic. It also reports the association between working conditions and psychological distress experienced by jun... Read More about Relationship between working conditions and psychological distress experienced by junior doctors in the UK during the COVID-19 pandemic: a cross-sectional survey study..

Available tools to evaluate digital health literacy and engagement with eHealth resources: A scoping review (2022)
Journal Article
Faux-Nightingale, A., Philp, F., Chadwick, D., Singh, B., & Pandyan, A. (2022). Available tools to evaluate digital health literacy and engagement with eHealth resources: A scoping review. Heliyon, 8(8), Article e10380. https://doi.org/10.1016/j.heliyon.2022.e10380

Background As eHealth and use of information and communication technologies (ICT) within healthcare becomes widespread, it is important to ensure that these forms of healthcare are accessible to the users. One factor that is key to accessing eHealth... Read More about Available tools to evaluate digital health literacy and engagement with eHealth resources: A scoping review.

The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Hider, S., Ranasinghe, . P., Helliwell, T., Lawton, S. A., …Mallen, C. (2022). The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study. Rheumatology Advances in Practice, 6(3), https://doi.org/10.1093/rap/rkac070

Objectives To determine the impact of polymyalgia rheumatica (PMR) on intimate and sexual relationships over time. Methods The PMR Cohort study (UKCRN ID16477) is a longitudinal study of patients with incident PMR in English primary care. Participant... Read More about The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study.

Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. (2022)
Journal Article
Mostafa, O., Sabry, D., Fouly, M., Ebrahim, N., El-Halim, H., Helal, O., …Salim, R. (2022). Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. Biomedicine and Pharmacotherapy, 113554 - ?. https://doi.org/10.1016/j.biopha.2022.113554

BACKGROUND: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a promising cell-free therapy optio... Read More about Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway..

Was the impact of COVID‐19 on a spinal triage service as significant as expected? A retrospective service evaluation: Results and evaluation (2022)
Journal Article
Wood, L., Eveleigh, C., Dixon, M., Dunstan, E., & Salem, K. (2022). Was the impact of COVID‐19 on a spinal triage service as significant as expected? A retrospective service evaluation: Results and evaluation. Musculoskeletal Care, 20(3), 697-704. https://doi.org/10.1002/msc.1680

OBJECTIVES: The aim of this evaluation was to review service outcomes for a spinal advanced practitioner physiotherapy (APP) triage service during COVID-19. The evaluation compares outcomes gathered against pre-pandemic data and evaluates the impact... Read More about Was the impact of COVID‐19 on a spinal triage service as significant as expected? A retrospective service evaluation: Results and evaluation.

Benchmarking community/primary care musculoskeletal services: A narrative review and recommendation (2022)
Journal Article
Burgess, R., Lewis, M., & Hill, J. (2023). Benchmarking community/primary care musculoskeletal services: A narrative review and recommendation. Musculoskeletal Care, 21(1), 148-158. https://doi.org/10.1002/msc.1676

INTRODUCTION: High quality data on service performance is essential in healthcare to evidence efficacy, efficiency, and value. There remains a paucity of publicly reported data in community and primary care musculoskeletal (MSK) services. There is al... Read More about Benchmarking community/primary care musculoskeletal services: A narrative review and recommendation.

Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow - protocol for the OPTimisE pilot and feasibility randomised controlled trial. (2022)
Journal Article
Bateman, M., Saunders, B., Littlewood, C., Davis, D., Beckhelling, J., Cooper, K., …Hill, J. (2022). Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow - protocol for the OPTimisE pilot and feasibility randomised controlled trial. Pilot and Feasibility Studies, 8, Article 178. https://doi.org/10.1186/s40814-022-01132-x

BACKGROUND: Physiotherapy is recommended for people with tennis elbow, but whilst a wide array of treatments is available, the optimal approach remains uncertain. We have therefore recently developed an optimised physiotherapy treatment package for t... Read More about Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow - protocol for the OPTimisE pilot and feasibility randomised controlled trial..

Implementing a new physiotherapist-led primary care model for low back pain: a qualitative study of patient and primary care team perspectives. (2022)
Journal Article
Hill, J. (2022). Implementing a new physiotherapist-led primary care model for low back pain: a qualitative study of patient and primary care team perspectives. BMC Primary Care, https://doi.org/10.1186/s12875-022-01817-5

BACKGROUND: Low back pain (LBP) is one of the most common reasons for primary care visits and is the leading contributor to years lived with disability worldwide. The purpose of this study was to understand the perspectives of patients and primary ca... Read More about Implementing a new physiotherapist-led primary care model for low back pain: a qualitative study of patient and primary care team perspectives..

The impact of clinical simulation on the development of advanced practice skills. (2022)
Journal Article
(2022). The impact of clinical simulation on the development of advanced practice skills. British Journal of Nursing, 780 - 788. https://doi.org/10.12968/bjon.2022.31.15.780

This article considers the findings of a qualitative research study into the impact of simulation on the development of advanced clinical practitioners' skills and knowledge. STUDY AIM: To explore simulated learning through the eyes of trainee and tr... Read More about The impact of clinical simulation on the development of advanced practice skills..

Using individual participant data to improve network meta-analysis projects. (2022)
Journal Article
(2022). Using individual participant data to improve network meta-analysis projects. BMJ Evidence-Based Medicine, https://doi.org/10.1136/bmjebm-2022-111931

A network meta-analysis combines the evidence from existing randomised trials about the comparative efficacy of multiple treatments. It allows direct and indirect evidence about each comparison to be included in the same analysis, and provides a cohe... Read More about Using individual participant data to improve network meta-analysis projects..

Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (2022)
Journal Article
Stables, R. H., Mullen, L. J., Elguindy, M., Nicholas, Z., Aboul-Enien, Y. H., Kemp, I., …Curzen, N. (2022). Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial. Circulation, 146(9), 687-698. https://doi.org/10.1161/CIRCULATIONAHA.121.057793

Background: Measurement of fractional flow reserve (FFR) has an established role in guiding percutaneous coronary intervention. We tested the hypothesis that, at the stage of diagnostic invasive coronary angiography, systematic FFR-guided assessment... Read More about Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial.

EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro (2022)
Journal Article
Chari, D., Basit, R. H., Wiseman, J., & Chari, D. M. (2022). EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro. British Journal of Surgery, 109(Supplement_5), https://doi.org/10.1093/bjs/znac245.072

Introduction/Aims Functional recovery in penetrating traumatic brain injury (pTBI) is hampered due to the lack of clinically approved regenerative therapies. Although a surgical emergency, pTBI management is largely supportive, with no targeted neuro... Read More about EP-273 Magnetic nanoparticle administration to a model of penetrating neurotrauma in vitro.

SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics (2022)
Journal Article
Chari, Basit, R. H., Wiseman, J., & Chari, D. M. (2022). SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics. British Journal of Surgery, 109(Supplement_5), https://doi.org/10.1093/bjs/znac247.047

Introduction/Aims Penetrating traumatic brain injury (pTBI) is a surgical emergency, with poor clinical outcomes. Management is supportive including surgical wound debridement, anti-epileptic administration and infection prophylaxis; no clinical neur... Read More about SP5.1.1 Novel in vitro model of neurotrauma to study neurotherapeutics.

Delegation of workload from musculoskeletal physiotherapists to physiotherapy assistants/support workers: A UK online survey. (2022)
Journal Article
Sarigiovannis, P., Foster, N., Jowett, S., & Saunders, B. (2022). Delegation of workload from musculoskeletal physiotherapists to physiotherapy assistants/support workers: A UK online survey. Musculoskeletal Science and Practice, 62, Article 102631. https://doi.org/10.1016/j.msksp.2022.102631

PURPOSE: There are approximately 9000 physiotherapy assistants/support workers in the UK. Many of them work in NHS physiotherapy outpatient services treating patients with musculoskeletal conditions, but their role(s) are relatively undefined and as... Read More about Delegation of workload from musculoskeletal physiotherapists to physiotherapy assistants/support workers: A UK online survey..

Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation. (2022)
Journal Article
Mamas. (2022). Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation. https://doi.org/10.1016/j.amjcard.2022.06.042

Randomized controlled trials evaluating the efficacy of vasopressin versus standard of care during cardiopulmonary resuscitation (CPR) have yielded conflicting results. An electronic search of MEDLINE, Cochrane, and Embase databases was conducted thr... Read More about Meta-Analysis of Efficacy of Vasopressin During Cardiopulmonary Resuscitation..

Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome. (2022)
Journal Article
Hattle, M., Riley, R. D., Collins, G. S., Whittle, R., & Ensor, J. (2022). Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome. Statistics in Medicine, 41(24), 4822-4837. https://doi.org/10.1002/sim.9538

Before embarking on an individual participant data meta-analysis (IPDMA) project, researchers and funders need assurance it is worth their time and cost. This should include consideration of how many studies are promising their IPD and, given the cha... Read More about Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome..

Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis. (2022)
Journal Article
Mamas. (2022). Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis. https://doi.org/10.1093/ehjci/jeac146

AIMS: Aortic stenosis (AS) and cardiac amyloidosis (CA) frequently coexist but the diagnosis of CA in AS patients remains a diagnostic challenge. We aim to evaluate the echocardiographic parameters that may aid in the detection of the presence of CA... Read More about Echocardiographic predictors of presence of cardiac amyloidosis in aortic stenosis..

Comparative analysis of pre-Covid19 child immunization rates across 30 European countries and identification of underlying positive societal and system influences. (2022)
Journal Article
(2022). Comparative analysis of pre-Covid19 child immunization rates across 30 European countries and identification of underlying positive societal and system influences. PloS one, -. https://doi.org/10.1371/journal.pone.0271290

This study provides a macro-level societal and health system focused analysis of child vaccination rates in 30 European countries, exploring the effect of context on coverage. The importance of demography and health system attributes on health care d... Read More about Comparative analysis of pre-Covid19 child immunization rates across 30 European countries and identification of underlying positive societal and system influences..

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Boyce, R., Lawton, S., Hurst, M., …Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England. https://doi.org/10.1080/13696998.2022.2102355

OBJECTIVE: The PULsE-AI trial sought to determine the effectiveness of a screening strategy that included a machine learning risk prediction algorithm in conjunction with diagnostic testing for identification of undiagnosed atrial fibrillation (AF) i... Read More about Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England.