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All Outputs (553)

Intra-sphincteric botulinum toxin in the management of functional biliary pain (2022)
Journal Article
(2022). Intra-sphincteric botulinum toxin in the management of functional biliary pain. Endoscopy International Open, E521 - E527. https://doi.org/10.1055/a-1784-0061

Abstract Background and study aims The management of functional biliary-type pain remains a clinical challenge. Intra sphincteric botulinum toxin putatively exerts an anti-spasmodic and anti-nociceptive effect. The objective of this study was to exam... Read More about Intra-sphincteric botulinum toxin in the management of functional biliary pain.

Sample size and precision of estimates in studies of depression screening tool accuracy: A meta‐research review of studies published in 2018–2021 (2022)
Journal Article
Nassar, E., Levis, B., Neyer, M. A., Rice, D. B., Booij, L., Benedetti, A., & Thombs, B. D. (in press). Sample size and precision of estimates in studies of depression screening tool accuracy: A meta‐research review of studies published in 2018–2021. International Journal of Methods in Psychiatric Research, 31(2), https://doi.org/10.1002/mpr.1910

AbstractObjectivesDepression screening tool accuracy studies should be conducted with large enough sample sizes to generate precise accuracy estimates. We assessed the proportion of recently published depression screening tool diagnostic accuracy stu... Read More about Sample size and precision of estimates in studies of depression screening tool accuracy: A meta‐research review of studies published in 2018–2021.

Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2022)
Journal Article
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., …Bliss, J. M. (2022). Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. Clinical Cancer Research, 28(7), 1323 - 1334. https://doi.org/10.1158/1078-0432.CCR-21-3177

PURPOSE: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. PATIENTS AND METHODS: This randomized phase II, two-part, multicenter trial included newly... Read More about Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.

The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review. (2022)
Journal Article
Kwok, C. S., Muntean, E., & Mallen, C. D. (2022). The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review. Journal of Medical Virology, 94(8), 3634-3641. https://doi.org/10.1002/jmv.27758

The spread of COVID-19 infection has changed the world. Population-based studies of COVID-19 are limited because it is unknown why events happen or why certain outcomes occur. An alternative approach called the patient pathway review evaluates what h... Read More about The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review..

Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis (2022)
Journal Article
Mamas, M. (2022). Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis. https://doi.org/10.1016/j.ijcha.2022.100975

Background Intravascular lithotripsy (IVL) can be used to assist stent deployment in severe coronary artery calcifications (CAC). Methods Studies employing IVL for CAC lesions were included. The primary outcomes included clinical and angiographi... Read More about Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis.

Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample. (2022)
Journal Article
Mamas. (2022). Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample. Expert Review of Cardiovascular Therapy, 233 - 240. https://doi.org/10.1080/14779072.2022.2058931

BACKGROUND: Inpatient management and outcomes of patients presenting with acute myocardial infarction (AMI) with a history of heart failure (HF) have not been well characterized. METHODS: Hospitalizations for AMI from the Nationwide Inpatient Sample... Read More about Management and outcomes of acute myocardial infarction in patients with preexisting heart failure: an analysis of 2 million patients from the national inpatient sample..

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy (2022)
Thesis
Hoolachan, J. M. (2022). A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy. (Thesis). Keele University

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder (NMD) caused by depleted survival of motor neuron (SMN) levels and characterised by neuronal degeneration and progressive muscle atrophy. Although three approved SMN-depen... Read More about A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy.

Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials (2022)
Thesis
Chowdhury, F. (2022). Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials. (Thesis). Keele University

Oligodendrocyte lineage and neuronal cells are essential neural populations required for axonal remyelination after spinal cord injury (SCI). Injection of an exogenous cell population into the site of neural injury has posed translational barriers, s... Read More about Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials.

A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT (2022)
Journal Article
Littlewood, E., Chew-Graham, C. A., Coleman, E., Gascoyne, S., Sloan, C., Ali, S., …Ekers, D. (2022). A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT. Public Health Research, 10(5), 1-160. https://doi.org/10.3310/ekze0617

Background Depression is common in people with long-term health conditions, and this combination can lead to worsened health outcomes and increased health-care costs. Subthreshold depression, a risk factor for major depression, is prevalent in this p... Read More about A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT.

Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. (2022)
Journal Article
Luo, J., Mobley, R., Woodfine, S., Drijfhout, F., Horrocks, P., Ren, X., & Li, W. (2022). Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. Applied Microbiology and Biotechnology, 106, 2433-2444. https://doi.org/10.1007/s00253-022-11888-0

Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A panel of microo... Read More about Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger..

The aetiological relationship between depressive symptoms and health-related quality of life: A population-based twin study in Sri Lanka. (2022)
Journal Article
(2022). The aetiological relationship between depressive symptoms and health-related quality of life: A population-based twin study in Sri Lanka. PloS one, e0265421 - ?. https://doi.org/10.1371/journal.pone.0265421

OBJECTIVE: Depression often co-occurs with poor health-related quality of life (HRQL). Twin studies report genetic and individual-level environmental underpinnings in the aetiology of both depression and HRQL, but there is limited twin research explo... Read More about The aetiological relationship between depressive symptoms and health-related quality of life: A population-based twin study in Sri Lanka..

Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar (2022)
Journal Article
Hamed, E., Alemrayat, B., Syed, M., Daher-Nashif, S., Rasheed, H., & Kane, T. (2022). Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar. International Journal of Environmental Research and Public Health, 3995 - 3995. https://doi.org/10.3390/ijerph19073995

This cross-sectional study examines knowledge, attitudes, and practices surrounding breast cancer awareness and screening among women residents in Qatar. Females, >18 years old, registered with the Primary Health Care Corporation were invited to c... Read More about Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar.

CLINICAL MANAGEMENT OF OSTEOARTHRITIS FLARES: A SCOPING REVIEW OF BEHAVIORAL, LIFESTYLE AND ADJUNCTIVE TREATMENTS (2022)
Journal Article
Bowden, J., Kobayashi, S., Hunter, D., Mills, K., Peat, G., Guillemin, F., …Eyles, J. (2022). CLINICAL MANAGEMENT OF OSTEOARTHRITIS FLARES: A SCOPING REVIEW OF BEHAVIORAL, LIFESTYLE AND ADJUNCTIVE TREATMENTS. Osteoarthritis and Cartilage, 30(S1), S396. https://doi.org/10.1016/j.joca.2022.02.532

Purpose: Transient episodes of increased pain, swelling and stiffness are common in people with osteoarthritis (OA). These episodes, commonly known as OA flares, can be distressing, disabling, and prompt informal and formal care-seeking. Yet evidence... Read More about CLINICAL MANAGEMENT OF OSTEOARTHRITIS FLARES: A SCOPING REVIEW OF BEHAVIORAL, LIFESTYLE AND ADJUNCTIVE TREATMENTS.

Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes (2022)
Presentation / Conference
Fryer, A., Holland, D., Stedman, M., Duff, C., Green, L., Scargill, J., …Heald, A. (2022, March). Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes. Poster presented at Diabetes UK Professional Conference 2022, Hybrid/Online

Introduction: Frequency of HbA1c testing links to outcome in terms of HbA1c control in diabetes. The influence of the variability of test-retest interval on HbA1c change needs to be determined. Methods: HbA1c results were collected from laboratory... Read More about Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes.

THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK (2022)
Journal Article
Thissen, G., Middelkoop van, M., Colaris, J., Selles, R., Dziedzic, K., Nicholls, E., & Bierma-Zeinstra, S. (2022). THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK. Osteoarthritis and Cartilage, 30, S423. https://doi.org/10.1016/j.joca.2022.02.577

Purpose: The hand joints are frequently affected by osteoarthritis (OA) in the adult population. Patients whose pain and disability are persistent may benefit from surgical treatment. However, based on current evidence, small and moderate effect size... Read More about THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK.

PREDICTION MODELS TO ESTIMATE FUTURE INDIVIDUAL RISK OF OSTEOARTHRITIS IN THE GENERAL POPULATION: A SYSTEMATIC REVIEW (2022)
Journal Article
Appleyard, T., Antcliff, D., Thomas, M., & Peat, G. (2022). PREDICTION MODELS TO ESTIMATE FUTURE INDIVIDUAL RISK OF OSTEOARTHRITIS IN THE GENERAL POPULATION: A SYSTEMATIC REVIEW. Osteoarthritis and Cartilage, 30, S22. https://doi.org/10.1016/j.joca.2022.02.019

Purpose: The need for health systems to shift from late, reactive care of osteoarthritis (OA) to earlier, preventative strategies is widely acknowledged. Rigorously derived and validated models capable of predicting future individual-level risk of OA... Read More about PREDICTION MODELS TO ESTIMATE FUTURE INDIVIDUAL RISK OF OSTEOARTHRITIS IN THE GENERAL POPULATION: A SYSTEMATIC REVIEW.

Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion (2022)
Journal Article
Wong, A. M., Ding, X., Wong, A. M., Xu, M., Zhang, L., Leung, H. H., …Wong, N. (2022). Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion. Journal of Hepatology, 77(2), 410-423. https://doi.org/10.1016/j.jhep.2022.03.015

Background & Aims Metabolic syndrome can lead to the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) as part of the natural history of NAFLD. Despite a strong causative link, NAFLD-HCC is often... Read More about Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion.

Sociocultural insights on dementia care-giving in Arab and Muslim communities: the perspectives of family care-givers (2022)
Journal Article
Hammad, S. H., Daher-Nashif, S., Kane, T., & Al-Wattary, N. (2022). Sociocultural insights on dementia care-giving in Arab and Muslim communities: the perspectives of family care-givers. Ageing and society, Article PII S0144686X22000277. https://doi.org/10.1017/S0144686X22000277

Little is known about the experiences of informal family care-giving for persons with ADRD in the context of Arab and Muslim communities. This paper offers fresh insight into the less-studied private sphere of the home, showing how families respond t... Read More about Sociocultural insights on dementia care-giving in Arab and Muslim communities: the perspectives of family care-givers.