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Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2022)
Journal Article
Mamas, M. A., Sanghavi, R., Pana, T. A., Mamayusupova, H., Maidment, I., Fox, C., …Myint, P. K. (2022). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. British Journal of Clinical Pharmacology, 88(7), 3297-3306. https://doi.org/10.1111/bcp.15261

Background Higher medication anticholinergic burden is associated with increased risk of cardiovascular disease and cognitive decline. A mechanistic pathway has not been established. We aimed to determine whether inflammation may mediate these assoc... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Is There a Role for Triple Therapy After ACS? (2022)
Journal Article
Mamas. (2022). Is There a Role for Triple Therapy After ACS?. Current Cardiology Reports, 191 - 200. https://doi.org/10.1007/s11886-022-01634-3

PURPOSE OF REVIEW: The optimal antithrombotic strategy in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) remains the subject of controversy. In this article, we review the current evidence for the use of tr... Read More about Is There a Role for Triple Therapy After ACS?.

Widening access to the specialised foundation programme (2022)
Journal Article
Lambie. (2022). Widening access to the specialised foundation programme. British Journal of Hospital Medicine, 1 - 7

The specialised foundation programme, previously known as the academic foundation programme, is an alternate foundation training pathway for doctors that are interested in research, medical education and leadership. The programme is highly competiti... Read More about Widening access to the specialised foundation programme.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study. (2022)
Journal Article
Englund, M., Prieto-Alhambra, D., Zhang, W., Doherty, M., Swain, S., Coupland, C., …Bierma-Zeinstra, S. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2021.12.013

OBJECTIVE: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. METHODS: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study..

Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis. (2022)
Journal Article
Mamas. (2022). Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis

AIMS: To evaluate the impact of systematic predilation with balloon aortic valvuloplasty (BAV) on transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: We performed a systematic meta-analysis investigating patients undergoing TAVI with... Read More about Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis..

Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. (2022)
Journal Article
Aktaa, S., Yadegarfar, M. E., Wu, J., Rashid, M., de Belder, M., Deanfield, J., …Gale, C. P. (2022). Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. https://doi.org/10.1136/bmjqs-2021-013040

BACKGROUND AND OBJECTIVE: The impact of the COVID-19 pandemic on the quality of care for patients with acute myocardial infarction (AMI) is uncertain. We aimed to compare quality of AMI care in England and Wales during and before the COVID-19 pandemi... Read More about Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study..

Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT. (2022)
Journal Article
Griffin, D. R., Dickenson, E. J., Achana, F., Griffin, J., Smith, J., Wall, P. D., …Donovan, J. (2022). Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT. Health Technology Assessment, 26(16), 1-236. https://doi.org/10.3310/fxii0508

Background Femoroacetabular impingement syndrome is an important cause of hip pain in young adults. It can be treated by arthroscopic hip surgery or with physiotherapist-led conservative care. Objective To compare the clinical effectiveness and cost-... Read More about Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT..

Computer-based stratified care in general practice for common musculoskeletal consultations: Results of the STarT MSK cluster randomised controlled trial (ISRCTN15366334) (2022)
Journal Article
Hill, J., Garvin, S., Bromley, K., Saunders, B., Kigozi, J., Cooper, V., …Foster, N. (2022). Computer-based stratified care in general practice for common musculoskeletal consultations: Results of the STarT MSK cluster randomised controlled trial (ISRCTN15366334). Physiotherapy, 114, e5. https://doi.org/10.1016/j.physio.2021.12.245

Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample (2022)
Journal Article
Bajpai, R., Zhu, X., Olsson, M. M., Goh, L. J., & Lim, V. H. (2022). Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample. Advances in skin & wound care, 35(1), 22 - 29. https://doi.org/10.1097/01.ASW.0000801524.42349.4d

OBJECTIVE To identify and determine patient- and ulcer-related factors associated with healing outcomes within 3 months for patients with diabetic foot ulcer (DFU) in a multiethnic primary care sample. METHODS Retrospective data were collected over 3... Read More about Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample.

Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes (2022)
Journal Article
Mamas. (2022). Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care, 909-918. https://doi.org/10.2337/dc21-1113

OBJECTIVE To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (M... Read More about Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes.

Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes (2022)
Journal Article
Borovac, J. A., Mohamed, M. O., Kontopantelis, E., Alkhouli, M., Alraies, M. C., Cheng, R. K., …Mamas, M. A. (2022). Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes. Journal of Invasive Cardiology,

Objectives. To determine the average treatment effect (ATE) of primary percutaneous coronary intervention (pPCI) versus medical treatment (MT) on in-hospital outcomes across the spectrum of frailty in patients with ST-elevation myocardial infarction... Read More about Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes.

Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA (2022)
Journal Article
Chen, Y., Ma, Z., Yu, D., Jiang, Z., Wang, B., & Yuan, L. (2022). Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA. Environmental Geochemistry and Health, 44, 4423–4436. https://doi.org/10.1007/s10653-022-01204-0

Severe outcome particularly death is the largest burden of COVID-19. Clinical observations showed preliminary data that deficiency in certain trace elements, essential for the normal activity of immune system, may be associated with worse COVID-19 ou... Read More about Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA.

Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK (2022)
Journal Article
Taxiarchi, P., Kontopantelis, E., Kinnaird, T., Curzen, N., Ahmed, J., Zaman, A., …Mamas, M. A. (2022). Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK. Journal of Invasive Cardiology,

Objectives. This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to coronary chronic total occlusions (CTOs) and explores independent associations of clinical and p... Read More about Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK.

What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research. (2022)
Journal Article
(2022). What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research. Frontiers in Public Health, 776940 - ?. https://doi.org/10.3389/fpubh.2021.776940

Community and public engagement (CPE) is increasingly becoming a key component in global health research. The National Institute for Health Research (NIHR) is one of the leading funders in the UK of global health research and requires a robust CPE el... Read More about What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research..

Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study (2022)
Journal Article
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., …Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrology Dialysis Transplantation, 37(2), 271 - 284. https://doi.org/10.1093/ndt/gfab303

Background Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race. Methods A pros... Read More about Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study.