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All Outputs (623)

'If in Doubt, Sit Them Out': How Long to Return to Elite Cycling Competition following a Sports-Related Concussion (SRC)? (2023)
Journal Article
Heron, N., Jones, N., Cardwell, C., & Gomes, C. (2023). 'If in Doubt, Sit Them Out': How Long to Return to Elite Cycling Competition following a Sports-Related Concussion (SRC)?. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph20085449

INTRODUCTION: A concussion or sports-related concussion (SRC) is a traumatic brain injury induced by biomechanical forces. After a SRC diagnosis is made, a concussed individual must undergo a period away from competition while they return to their ba... Read More about 'If in Doubt, Sit Them Out': How Long to Return to Elite Cycling Competition following a Sports-Related Concussion (SRC)?.

Theory-informed strategies to address factors anticipated to influence implementation and people's participation in community pharmacy-based diabetes prevention services (2023)
Journal Article
Katangwe-Chigamba, T., Sokhi, J., Family, H., Al-Jabr, H., Kirkdale, C. L., & Twigg, M. J. (2023). Theory-informed strategies to address factors anticipated to influence implementation and people's participation in community pharmacy-based diabetes prevention services. Exploratory Research in Clinical and Social Pharmacy, 10, 100263. https://doi.org/10.1016/j.rcsop.2023.100263

Background Early identification of non-diabetic hyperglycaemia and implementation of diet and lifestyle changes can prevent type 2 diabetes. However, low participation in diabetes prevention services remains a problem in the UK. The community pharma... Read More about Theory-informed strategies to address factors anticipated to influence implementation and people's participation in community pharmacy-based diabetes prevention services.

Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials. (2023)
Journal Article
Hamed, M., Elseidy, S. A., Abdelazeem, M., Morcos, R., Abdallah, A., Sammour, Y., …Elbadawi, A. (2023). Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials. EP-Europace, https://doi.org/10.1093/europace/euad080

AIMS: To evaluate the efficacy of oesophageal cooling in the prevention of oesophageal injury in patients undergoing atrial fibrillation (AF) catheter ablation. METHODS AND RESULTS: Comprehensive search of MEDLINE, EMBASE, and Cochrane databases thro... Read More about Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and meta-analysis of randomized controlled trials..

Interventions for Perceptual Disorders in Stroke: A Systematic Review (2023)
Journal Article
Hazelton, C., Thomson, K., Todhunter-Brown, A., Campbell, P., Chung, C. S. Y., Dorris, L., …Brady, M. C. (2023). Interventions for Perceptual Disorders in Stroke: A Systematic Review. Stroke, 54(6), e239-e240. https://doi.org/10.1161/STROKEAHA.123.041957

Perception is the ability to recognize and interpret information from our senses. It is fundamental to an individual’s ability to understand and interact with their environment. Disorders of perception are common after stroke, reducing quality of lif... Read More about Interventions for Perceptual Disorders in Stroke: A Systematic Review.

Systematic review finds "spin"practices and poor reporting standards in studies on machine learning-based prediction models (2023)
Journal Article
Navarro, C. L. A., Damen, J. A. A., Takada, T., Nijman, S. W. J., Dhiman, P., Ma, J., …Hooft, L. (2023). Systematic review finds "spin"practices and poor reporting standards in studies on machine learning-based prediction models. Journal of Clinical Epidemiology, 158, 99-110. https://doi.org/10.1016/j.jclinepi.2023.03.024

OBJECTIVE: We evaluated the presence and frequency of spin practices and poor reporting standards in studies that developed and/or validated clinical prediction models using supervised machine learning techniques. STUDY DESIGN AND SETTING: We sys... Read More about Systematic review finds "spin"practices and poor reporting standards in studies on machine learning-based prediction models.

Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors (2023)
Journal Article
Menz, H. B., Allan, J. J., Buldt, A. K., Landorf, K. B., Cicuttini, F. M., Roddy, E., & Munteanu, S. E. (2023). Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors. Arthritis Care and Research, 75(10), 2127-2133. https://doi.org/10.1002/acr.25125

OBJECTIVE: To determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). METHODS: Ninety-eight participants (mean age 57.4?years, standard deviation 10.3) with symptomatic radiographic first MTP join... Read More about Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors.

Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. (2023)
Journal Article
Tužil, J., Matějka, J., Mamas, M. A., & Doležal, T. (2023). Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. Expert Review of Cardiovascular Therapy, 293 - 304. https://doi.org/10.1080/14779072.2023.2187378

OBJECTIVES: To verify whether transradial (TRA) compared to transfemoral (TFA) cardiac catheterization reduces the risk of periprocedural stroke (PS). METHODS: We reviewed (CRD42021277918) published real-world cohorts reporting the incidence of PS wi... Read More about Short-term risk of periprocedural stroke relative to radial vs. femoral access: systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations..

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan. (2023)
Journal Article
Valkovskaya, M., Hassan, A., Zartaloudi, E., Hussain, F., Umar, M., Khizar, B., …Kuchenbaecker, K. (2023). Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan. Psychiatric Genetics, 33(2), 69-78. https://doi.org/10.1097/ypg.0000000000000333

INTRODUCTION: Globally, 80% of the burdenof major depressive disorder (MDD) pertains to low- and middle-income countries. Research into genetic and environmental risk factors has the potential to uncover disease mechanisms that may contribute to bett... Read More about Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan..

Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3) (2023)
Journal Article
Smith, L., Sim, J., Cutts, M., Dasch, H., Amlôt, R., Sevdalis, N., …Sherman, S. (2023). Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3). https://doi.org/10.1016/j.jvacx.2023.100276

Background We investigated factors associated with COVID-19 vaccine uptake, future vaccination intentions, and changes in beliefs and attitudes over time. Methods Prospective cohort study. 1500 participants completed an online survey in January... Read More about Psychosocial factors affecting COVID-19 vaccine uptake in the UK: a prospective cohort study (CoVAccS – wave 3).

Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. (2023)
Journal Article
Sokhal, B., Matetić, A., Rashid, M., Protheroe, J., Partington, R., Mallen, C., & Mamas, M. (2023). Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. American Journal of Cardiology, 7 - 15. https://doi.org/10.1016/j.amjcard.2022.12.029

Data are limited about the contemporary association between frailty and the causes and outcomes of patients admitted with cardiovascular diseases (CVD). Using the US National Inpatient Sample, CVD admissions of interest (acute myocardial infarction,... Read More about Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease..

Impact of different practice patterns on solute transport in peritoneal dialysis (2023)
Thesis
Brenna, I. (2023). Impact of different practice patterns on solute transport in peritoneal dialysis. (Thesis). Keele University

Long term peritoneal dialysis (PD) is associated with increased peritoneal solute transport rate (PSTR) and loss of ultrafiltration capacity [1,2], both reflecting acquired structural alterations of the peritoneal membrane. Peritoneal functional chan... Read More about Impact of different practice patterns on solute transport in peritoneal dialysis.

Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy (2023)
Thesis
Sutton, E. R. (2023). Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a neuromuscular disease characterised by loss of alpha motor neurons and muscle atrophy. When untreated, mortality occurs within the first two years of life in the most severe cases. Extensive research has led to thre... Read More about Investigating the therapeutic potential of the glucocorticoid antagonist, mifepristone, for the treatment of spinal muscular atrophy.

The association between gout and psychological co-morbidity: results from a prospective cohort study (2023)
Thesis
Higgs, J. J. R. (2023). The association between gout and psychological co-morbidity: results from a prospective cohort study. (Thesis). Keele University

Gout is associated with an increased risk of both physical-health co-morbidities and a reduction in physical health-related quality of life. However, the association between gout and psychological comorbidity (depression and anxiety) has received lit... Read More about The association between gout and psychological co-morbidity: results from a prospective cohort study.

Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data (2023)
Thesis
Huang, X. (2023). Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data. (Thesis). Keele University

For adults aged 45 and over in the United Kingdom (UK), osteoarthritis is a common reason for consultation with primary care. Cardiovascular disease (CVD) is a common comorbidity with osteoarthritis; two in five people with osteoarthritis also have C... Read More about Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data.

Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2023)
Dataset
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., …Bliss, J. M. (2023). Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. [Dataset]. https://doi.org/10.1158/1078-0432.c.6532623.v1

Purpose: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. Patients and Methods: This randomized phase II, two-part, multicenter trial included n... Read More about Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.

Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2023)
Dataset
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., M. Shaaban, A., …Bliss, J. M. (2023). Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. [Dataset]. https://doi.org/10.1158/1078-0432.c.6532623

Purpose: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. Patients and Methods: This randomized phase II, two-part, multicenter trial included n... Read More about Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.