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Folate supplementation as a beneficial add‐on treatment in relieving depressive symptoms: A meta‐analysis of meta‐analyses (2024)
Journal Article
Gao, S., Khalid, A., Amini‐Salehi, E., Radkhah, N., Jamilian, P., Badpeyma, M., & Zarezadeh, M. (in press). Folate supplementation as a beneficial add‐on treatment in relieving depressive symptoms: A meta‐analysis of meta‐analyses. Food Science and Nutrition, https://doi.org/10.1002/fsn3.4073

The results of meta‐analyses investigating the role of folate on depression are conflicting. The aim of this umbrella meta‐analysis was to obtain an overall effect and give a concise and resolving conclusion. International scientific databases includ... Read More about Folate supplementation as a beneficial add‐on treatment in relieving depressive symptoms: A meta‐analysis of meta‐analyses.

How common are side effects of treatment to prevent gout flares when starting allopurinol? (2024)
Journal Article
Saul, H., Deeney, B., Swaithes, L., & Roddy, E. (in press). How common are side effects of treatment to prevent gout flares when starting allopurinol?. BMJ, 384, Article q514. https://doi.org/10.1136/bmj.q514

The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. 2023;82:1618-25.To re... Read More about How common are side effects of treatment to prevent gout flares when starting allopurinol?.

Telerehabilitation consultations with a physiotherapist for chronic knee pain versus in-person consultations in Australia: the PEAK non-inferiority randomised controlled trial. (2024)
Journal Article
Hinman, R. S., Campbell, P. K., Kimp, A. J., Russell, T., Foster, N. E., Kasza, J., …Bennell, K. L. (in press). Telerehabilitation consultations with a physiotherapist for chronic knee pain versus in-person consultations in Australia: the PEAK non-inferiority randomised controlled trial. The Lancet, 403(10433), 1267-1278. https://doi.org/10.1016/S0140-6736%2823%2902630-2

Telerehabilitation whether perceived as less effective than in-person care for musculoskeletal problems. We aimed to determine if physiotherapy video conferencing consultations were non-inferior to in-person consultations for chronic knee pain. In th... Read More about Telerehabilitation consultations with a physiotherapist for chronic knee pain versus in-person consultations in Australia: the PEAK non-inferiority randomised controlled trial..

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background: Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article
Damery, S., Lambie, M., Williams, I., Coyle, D., Fotheringham, J., Solis-Trapala, I., …Davies, S. J. (in press). Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241232200

Background: Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives To examine the cross-sectional association between health literacy and gout characteristics. Methods In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

Fatigue and vigilance in medical experts detecting breast cancer (2024)
Journal Article
Taylor-Phillips, S., Jenkinson, D., Stinton, C., Kunar, M. A., Watson, D. G., Freeman, K., …Clarke, A. (2024). Fatigue and vigilance in medical experts detecting breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 121(11), https://doi.org/10.1073/pnas.2309576121

An abundance of laboratory-based experiments has described a vigilance decrement of reducing accuracy to detect targets with time on task, but there are few real-world studies, none of which have previously controlled the environment to control for b... Read More about Fatigue and vigilance in medical experts detecting breast cancer.

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia (2024)
Journal Article
Španić Popovački, E., Vogrinc, D., Fuller, H., Langer Horvat, L., Mayer, D., Kopić, J., … Šimić, G. (2024). Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia. Biomolecules, 14(3), Article 302. https://doi.org/10.3390/biom14030302

Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction. In the context of major developmental hypotheses of... Read More about Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia.

Motiv8: a study protocol for a cluster-randomised feasibility trial of a weight management intervention for adults with severe mental illness in secure forensic services (2024)
Journal Article
Carney, R., El-Metaal, H., Law, H., Savage, S., Small, I., Hann, M., …Parker, S. (in press). Motiv8: a study protocol for a cluster-randomised feasibility trial of a weight management intervention for adults with severe mental illness in secure forensic services. Pilot and Feasibility Studies, 10(1), 48. https://doi.org/10.1186/s40814-024-01458-8

Introduction: People with severe mental illness have physical comorbidities which result in significant reductions in quality of life and premature mortality. Effective interventions are required that are suitable for people in secure forensic mental... Read More about Motiv8: a study protocol for a cluster-randomised feasibility trial of a weight management intervention for adults with severe mental illness in secure forensic services.

“We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations (2024)
Journal Article
Gidlow, C. J., Sams, L., Buckless, K., Ellis, N. J., Duffy, H. C., Lambley-Burke, R., …Mallen, C. D. (2024). “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations. BMC Health Services Research, 24(1), Article 264. https://doi.org/10.1186/s12913-024-10760-3

The introduction of Integrated Care Systems (ICS) in England aimed to increase joint planning and delivery of health and social care, and other services, to better meet the needs of local communities. There is an associated duty to undertake collabor... Read More about “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations.

The International Olympic Committee framework on fairness, inclusion and nondiscrimination on the basis of gender identity and sex variations does not protect fairness for female athletes (2024)
Journal Article
Lundberg, T. R., Tucker, R., McGawley, K., Williams, A. G., Millet, G. P., Sandbakk, Ø., …Hilton, E. N. (2024). The International Olympic Committee framework on fairness, inclusion and nondiscrimination on the basis of gender identity and sex variations does not protect fairness for female athletes. Scandinavian Journal of Medicine & Science in Sports, 34(3), Article e14581. https://doi.org/10.1111/sms.14581

The International Olympic Committee (IOC) recently published a framework on fairness, inclusion, and nondiscrimination on the basis of gender identity and sex variations. Although we appreciate the IOC's recognition of the role of sports science and... Read More about The International Olympic Committee framework on fairness, inclusion and nondiscrimination on the basis of gender identity and sex variations does not protect fairness for female athletes.

Adrenoceptor Desensitization: Current Understanding of Mechanisms. (2024)
Journal Article
Maaliki, D., Jaffa, A. A., Nasser, S., Sahbekar, A., & Eid, A. H. (2024). Adrenoceptor Desensitization: Current Understanding of Mechanisms. Pharmacological Reviews, 76(3), 358-387. https://doi.org/10.1124/pharmrev.123.000831

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biological functions including vision, olfaction, chemotaxis and immunity. However, as essential as most of them are to body... Read More about Adrenoceptor Desensitization: Current Understanding of Mechanisms..

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. (2024)
Journal Article
Sokhal, B. S., Menon, S. P. K., Willes, C., Corp, N., Matetić, A., Mallen, C., & Mamas, M. (in press). Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. Current Cardiology Reviews, 20(3), Article e290224227533. https://doi.org/10.2174/011573403X276647240217112151

There is limited systematic data on the association between the Hospital Frailty Risk Score (HFRS) and characteristics and mortality in patients with cerebrovascular and cardiovascular disease (CVD). This systematic review aimed to summarise the use... Read More about Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease..

Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis (2024)
Journal Article
Nimmons, D., Aker, N., Burnand, A., Jordan, K. P., Cooper, C., Davies, N., …Walters, K. (2024). Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 157, 105507. https://doi.org/10.1016/j.neubiorev.2023.105507

Radiation Exposure, Training, and Safety in Cardiology. (2024)
Journal Article
Tamirisa, K. P., Alasnag, M., Calvert, P., Islam, S., Bhardwaj, A., Pakanati, K., …Kort, S. (2024). Radiation Exposure, Training, and Safety in Cardiology. JACC: Advances, 3(4), Article 100863. https://doi.org/10.1016/j.jacadv.2024.100863

Exposure to ionizing radiation is an inherent occupational health hazard in clinical cardiology. Health risks have been reported previously, including predilection to cancer. In addition, orthopedic injury due to prolonged wearing of heavy protective... Read More about Radiation Exposure, Training, and Safety in Cardiology..