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Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. (2024)
Journal Article
Pan, X., Tan, B., Chin, Y. H., Lee, E. C. Z., Kong, G., Chong, B., …Chan, M. Y. (in press). Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. Obesity, 32(5), 840-856. https://doi.org/10.1002/oby.24002

This network meta-analysis evaluates the efficacy and safety of tirzepatide compared to glucagon-like peptide-1 receptor agonists (GLP-1 RA) and other weight loss drugs in the treatment of overweight and obesity. MEDLINE, Embase, and Cochrane CENTRAL... Read More about Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis..

Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry. (2024)
Journal Article
Kobo, O., Levi, Y., Abu-Fanne, R., Von Birgelen, C., Guédès, A., Aminian, A., …Roguin, A. (in press). Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry. IJC Heart & Vasculature, 51, Article 101370. https://doi.org/10.1016/j.ijcha.2024.101370

A substantial proportion of the patients undergoing percutaneous coronary intervention (PCI) have none of the of standard modifiable cardiovascular risk factors (SMuRFs): hypertension, diabetes, hypercholesterolaemia and smoking. The aim of this anal... Read More about Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry..

Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge (2024)
Journal Article
Acquaah, J., Ferdinand, P., & Roffe, C. (2024). Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge. BMJ Case Reports, 17(2), Article e256306. https://doi.org/10.1136/bcr-2023-256306

Rare causes of stroke-like presentations can be difficult to diagnose. We report a case of a man in his 40s who first presented with stroke symptoms, but whose clinical course was not typical for a stroke. A detailed investigation of the patient’s me... Read More about Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge.

How do medical schools influence their students’ career choices? A realist evaluation (2024)
Journal Article
Thomas, A., Kinston, R., Yardley, S., McKinley, R. K., & Lefroy, J. (2024). How do medical schools influence their students’ career choices? A realist evaluation. Medical Education Online, 29(1), https://doi.org/10.1080/10872981.2024.2320459

Introduction The career choices of medical graduates vary widely between medical schools in the UK and elsewhere and are generally not well matched with societal needs. Research has found that experiences in medical school including formal, informal... Read More about How do medical schools influence their students’ career choices? A realist evaluation.

Online health information-seeking behaviours for low back pain in the United Kingdom: analysis of data from Google trends and the Global Burden of Disease Study, 2004-2019. (2024)
Journal Article
Patel, H., & Shepherd, T. A. (in press). Online health information-seeking behaviours for low back pain in the United Kingdom: analysis of data from Google trends and the Global Burden of Disease Study, 2004-2019. International Health, Article ihae020. https://doi.org/10.1093/inthealth/ihae020

Low back pain (LBP) is a leading cause of global disability. Timely health-seeking is crucial for early diagnosis and management of pathologies. Despite increases in internet usage, there is sparse literature regarding online health information-seeki... Read More about Online health information-seeking behaviours for low back pain in the United Kingdom: analysis of data from Google trends and the Global Burden of Disease Study, 2004-2019..

Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer. (2024)
Journal Article
Abramov, D., Kobo, O., & Mamas, M. A. (2024). Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer. Journal of the American Heart Association, 13(5), Article e032683. https://doi.org/10.1161/JAHA.123.032683

Although metrics of cardiovascular health have been associated with improved mortality, whether the association remains among individuals with a history of cancer has not been well characterized. The National Health and Nutrition Examination Survey d... Read More about Association of Cardiovascular Health Metrics and Mortality Among Individuals With and Without Cancer..

Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020 (2024)
Journal Article
Boakye, E., Oyeka, C. P., Kwapong, Y. A., Metlock, F. E., Khan, S. S., Mamas, M. A., …Sharma, G. (2024). Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020. AJPM Focus, 3(4), Article 100210. https://doi.org/10.1016/j.focus.2024.100210

Introduction Suboptimal cardiovascular health is associated with adverse pregnancy outcomes and long-term cardiovascular risk. The authors examined trends in cardiovascular risk factors and correlates of suboptima... Read More about Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015–2020.

Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). (2024)
Journal Article
Miranda, R. N., Qiu, F., Manoragavan, R., Austin, P. C., Naimark, D. M. J., Fremes, S. E., …Wijeysundera, H. C. (2024). Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). Journal of the American Heart Association, 13(5), Article e033768. https://doi.org/10.1161/JAHA.123.033768

Transcatheter aortic valve implantation (TAVI) has seen indication expansion and thus exponential growth in demand over the past decade. In many jurisdictions, the growing demand has outpaced capacity, increasing wait times and preprocedural adverse... Read More about Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T)..

Improving patients’ experiences of diagnosis and treatment of vertebral fracture: co-production of knowledge sharing resources (2024)
Journal Article
Bennett, S. E., Gooberman-Hill, R., Clark, E. M., Paskins, Z., Walsh, N., & Drew, S. (in press). Improving patients’ experiences of diagnosis and treatment of vertebral fracture: co-production of knowledge sharing resources. BMC Musculoskeletal Disorders, 25(1), 165. https://doi.org/10.1186/s12891-024-07281-9

Background: Osteoporosis involves changes to bones that makes them prone to fracture. The most common osteoporotic fracture is vertebral, in which one or more spinal vertebrae collapse. People with vertebral fracture are at high risk of further fract... Read More about Improving patients’ experiences of diagnosis and treatment of vertebral fracture: co-production of knowledge sharing resources.

Outcomes Following Intact and Ruptured Aneurysm Repair across Nations: Analysis of International Registries Data from the VASCUNET Collaboration 2014 - 2019. (2024)
Journal Article
Pherwani, A. D., Johal, A. S., Cromwell, D. A., Boyle, J. R., Szeberin, Z., Venermo, M., …Budtz-Lilly, J. (in press). Outcomes Following Intact and Ruptured Aneurysm Repair across Nations: Analysis of International Registries Data from the VASCUNET Collaboration 2014 - 2019. European Journal of Vascular and Endovascular Surgery, S1078-5884(24)00178-3. https://doi.org/10.1016/j.ejvs.2024.02.019

To determine the peri-operative mortality for intact and ruptured abdominal aortic aneurysm (AAA) repair in 10 countries and to compare practice and outcomes over a 6 year period by age, sex, and geographical location. This VASCUNET study used prospe... Read More about Outcomes Following Intact and Ruptured Aneurysm Repair across Nations: Analysis of International Registries Data from the VASCUNET Collaboration 2014 - 2019..

A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing. (2024)
Journal Article
Mirhosseini, N., Li, L., Liu, Z., Mamas, M., Fraser, D., & Wang, T. (2024). A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing. Heliyon, 10(5), Article e26425. https://doi.org/10.1016/j.heliyon.2024.e26425

Complete endothelialisation of coronary stents is an important determinant of future thrombotic complications following coronary stenting. Stent surface texture is an important factor that influences endothelial cell growth. With the emergence of sec... Read More about A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing..

Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses (2024)
Journal Article
Pant, A., Chew, D. P., Mamas, M. A., & Zaman, S. (in press). Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses. Nutrients, 16(4), Article 570. https://doi.org/10.3390/nu16040570

Cardiovascular disease (CVD) is a leading cause of mortality and disease burden in women globally. A healthy diet is important for the prevention of CVD. Research has consistently favoured the Mediterranean diet as a cardio-protective diet. Several s... Read More about Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses.

The relationship between general practitioner movement behaviours with burnout and fatigue (2024)
Journal Article
Mayne, R. S., Biddle, G. J. H., Edwardson, C. L., Hart, N. D., Daley, A. J., & Heron, N. (in press). The relationship between general practitioner movement behaviours with burnout and fatigue. BMC Primary Care, 25(1), 60. https://doi.org/10.1186/s12875-024-02289-5

Background: Physical inactivity is associated with feelings of burnout and fatigue, which in turn are associated with reduced performance among healthcare practitioners. This study explored movement behaviours of general practitioners (GPs) and the a... Read More about The relationship between general practitioner movement behaviours with burnout and fatigue.

The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study. (2024)
Journal Article
Weight, N., Moledina, S., Hennessy, T., Jia, H., Banach, M., Rashid, M., …Mamas, M. A. (in press). The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study. European Heart Journal - Quality of Care and Clinical Outcomes, Article qcae015. https://doi.org/10.1093/ehjqcco/qcae015

The long-terms outcomes of out of hospital cardiac arrest (OHCA) survivors are not well known. Using the Myocardial Ischaemia National Audit Project (MINAP) registry, linked to Office for National Statistics (ONS) mortality data, we analysed 661 326... Read More about The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study..

Safety And Contagion In Acute Psychiatric Wards: how the milieu is implicated in the occurrence of clustered safety incidents (2024)
Journal Article
Canvin, K., Brierley-Jones, L., Ramsey, L., Baker, J., & Berzins, K. (2024). Safety And Contagion In Acute Psychiatric Wards: how the milieu is implicated in the occurrence of clustered safety incidents. Theory and Psychology, https://doi.org/10.1177/09593543231225636

In psychiatry, clustered safety incidents are often attributed to behavioural contagion. Drawing on Kindermann and Skinner’s conceptual work in our analysis of staff accounts, we explored whether clustered safety incidents could be attributable to co... Read More about Safety And Contagion In Acute Psychiatric Wards: how the milieu is implicated in the occurrence of clustered safety incidents.

Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope (2024)
Journal Article
Toyoda, T., Armitstead, Z., Bhide, S., Engamba, S., Henderson, E., Jones, C., …Yates, M. (in press). Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(1), Article rkae002. https://doi.org/10.1093/rap/rkae002

The last British Society for Rheumatology (BSR) guideline on PMR was published in 2009. The guideline needs to be updated to provide a summary of the current evidence for pharmacological and non-pharmacological management of adults with PMR. This gui... Read More about Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope.

Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data. (2024)
Journal Article
Wang, X., Li, Y., Shi, T., Bont, L. J., Chu, H. Y., Zar, H. J., …Nair, H. (in press). Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data. Lancet, 403(10433), 1241-1253. https://doi.org/10.1016/S0140-6736%2824%2900138-7

Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease burden of and risk factors for RSV-assoc... Read More about Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data..

Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study. (2024)
Journal Article
Sharma, V., Choudhury, A., Basavarajaiah, S., Rashid, M., Yuan, M., Jefferey, D., …Mamas, M. A. (in press). Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study. Cardiovascular Revascularization Medicine, 64, 62-67. https://doi.org/10.1016/j.carrev.2024.02.008

Objectives To evaluate the characteristics and outcomes of patients with a chronic total occlusion (CTO) in a Non-ST Elevation Myocardial Infarction (NSTEMI) cohort. Background There is limited data on the clinical characteristics, revascularisa... Read More about Chronic total occlusion in non-ST elevation myocardial infarction - A multi-centre observational study..

Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial (2024)
Journal Article
Cope, A. P., Jasenecova, M., Vasconcelos, J. C., Filer, A., Raza, K., Qureshi, S., …Quick, V. (2024). Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. The Lancet, 403(10429), 838-849. https://doi.org/10.1016/s0140-6736%2823%2902649-1