All Outputs (10)

Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies (2025)
Thesis
Dimmock, R. L. Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1109999

The limbal epithelial stem cell (LESC) niche is a vital stem cell pool which serves to replenish the cornea with competent stem cells for regrowth and repair throughout adult life. Injury and disease, such as limbal stem cell deficiency (LSCD), can d... Read More about Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies.

Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis
Xie, B. Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques. (Thesis). Keele University. https://keele-repository.worktribe.com/output/674529

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University. https://keele-repository.worktribe.com/output/420355

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/419489

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

Development of conjunctival and retinal models for improved eye disease treatments (2019)
Thesis
Gater, R. V. A. Development of conjunctival and retinal models for improved eye disease treatments. (Thesis). Keele University. https://keele-repository.worktribe.com/output/415221

Eye diseases such as glaucoma, macular degeneration and retinitis pigmentosa can lead to significant sight problems and blindness if left untreated. Current treatments are invasive, have a low success rate and lack the ability to regenerate damaged o... Read More about Development of conjunctival and retinal models for improved eye disease treatments.

Investigation of cellular and scaffold strategies for engineering articular cartilage (2018)
Thesis
Abu Owida, H. Investigation of cellular and scaffold strategies for engineering articular cartilage. (Thesis). Keele University. https://keele-repository.worktribe.com/output/412022

Articular cartilage is a thin hydrated tissue, which covers articulating surfaces. In the native articular cartilage tissue, the extracellular matrix (ECM) is a fibrillar mesh of interacting proteoglycans, collagens, and other non-collagenous protein... Read More about Investigation of cellular and scaffold strategies for engineering articular cartilage.

Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse (2018)
Thesis
Weli, H. K. Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411339

Introduction: Pelvic organ prolapse is present in up to 50% of women. It is commoner in older women, often above 50 years of age and associated with hormonal e.g. oestrogen decline, and stiffer vaginal tissue. Pregnancy, on the contrary is a physiolo... Read More about Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse.

Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis (2018)
Thesis
Musa, F. Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411162

In this project, we have designed, constructed, and validated a human tissue-engineered blood vessel construct (TEBV) to assess whether it could be used as a new model system in which to study thrombus formation under physiologically relevant conditi... Read More about Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis.

Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes (2018)
Thesis
Elttayef, A. A. J. Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411158

The islets of Langerhans are multicellular aggregates within the pancreas containing beta cells that sense changes in blood glucose level and respond by secreting insulin. The cells within the islets communicate with each other through gap junctions.... Read More about Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes.