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A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution (2012)
Journal Article
Strover, L. T., Malmström, J., Laita, O., Reynisson, J., Aydemir, N., Nieuwoudt, M. K., …Travas-Sejdic, J. (2013). A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution. Polymer, 54(4), 1305-1317. https://doi.org/10.1016/j.polymer.2012.11.083

We present the synthesis of a novel conducting polymer (CP) incorporating both pyrrole and thiophene units in its monomer, which is also substituted with an initiator for grafting of sidechains by atom-transfer radical polymerisation (ATRP). The prec... Read More about A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution.

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (2012)
Journal Article
McCoull, W., Barton, P., Broo, A., Brown, A. J. H., Clarke, D. S., Coope, G., …Williams, E. J. (2013). Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity. MedChemComm, 4(2), 456. https://doi.org/10.1039/c2md20340e

A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hE... Read More about Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity.

Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis (2012)
Journal Article
(2012). Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis. PloS one, e51350 -?. https://doi.org/10.1371/journal.pone.0051350

Gene delivery technologies to introduce foreign genes into highly differentiated mammalian cells have improved significantly over the last few decades. Relatively new techniques such as magnetic nanoparticle-based gene transfection technology are sho... Read More about Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis.

Oxidative rearrangement of tertiary propargylic alcohols (2012)
Journal Article
Rodríguez, A., & Moran, W. J. (2013). Oxidative rearrangement of tertiary propargylic alcohols. SYNLETT, 24(1), 102-104. https://doi.org/10.1055/s-0032-1317711

An oxidative rearrangement of tertiary alcohols mediated by m-CPBA is described that generates tetrasubstituted alkenes with a carboxylic acid substituent. The mechanism of the reaction is proposed to proceed through epoxidation of the alkyne to form... Read More about Oxidative rearrangement of tertiary propargylic alcohols.

Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice (2012)
Journal Article
Bake, T., Duncan, J. S., Morgan, D. G. A., & Mercer, J. G. (2013). Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice. Journal of Neuroendocrinology, 25(4), 357-371. https://doi.org/10.1111/jne.12008

Meal feeding is a critical issue in the over-consumption of calories leading to human obesity. To investigate the mechanisms involved in the regulation of meal feeding in rodents, we studied a scheduled feeding regime that induces substantial food in... Read More about Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice.

Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study (2012)
Journal Article
White. (2012). Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study. BMC Health Services Research, 425 -?. https://doi.org/10.1186/1472-6963-12-425

BACKGROUND: Non-adherence to prescribed medication is a pervasive problem that can incur serious effects on patients' health outcomes and well-being, and the availability of resources in healthcare systems. This study aimed to develop practical conse... Read More about Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study.

DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems (2012)
Journal Article
Hume, P. A., Brimble, M. A., & Reynisson, J. (2013). DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry, 1005, 9-15. https://doi.org/10.1016/j.comptc.2012.10.022

Mitomycin C is a DNA alkylating agent activated by bioreduction. It has been in clinical use against a range of solid tumours since the 1960s. Its DNA adduct formation mechanism has been extensively studied and it therefore presents an excellent test... Read More about DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems.

Atrial fibrillation in heart failure: an innocent bystander? (2012)
Journal Article
Mamas. (2012). Atrial fibrillation in heart failure: an innocent bystander?. Current Cardiology Reviews, 273 - 280. https://doi.org/10.2174/157340312803760839

Heart failure (HF) and atrial fibrillation (AF) frequently coexist and each complicates the course of the other. The purpose of this review is to analyse the prognostic impact of AF in patients with HF and assess whether there is an advantage in targ... Read More about Atrial fibrillation in heart failure: an innocent bystander?.

Student perceptions of the progress test in two settings and the implications for test deployment (2012)
Journal Article
(2012). Student perceptions of the progress test in two settings and the implications for test deployment. Advances in Health Sciences Education, 573-583. https://doi.org/10.1007/s10459-011-9334-z

Background The Progress Test (PT) was developed to assess student learning within integrated curricula. Whilst it is effective in promoting and rewarding deep approaches to learning in some settings, we hypothesised that implementation of the curricu... Read More about Student perceptions of the progress test in two settings and the implications for test deployment.

Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens (2012)
Journal Article
Cutting, R. S., Coker, V. S., Telling, N. D., Kimber, R. L., van der Laan, G., Pattrick, R. A. D., …Lloyd, J. R. (2012). Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens. Environmental Science and Technology, 46(22), 12591-12599. https://doi.org/10.1021/es204596z

The fate of As(V) during microbial reduction by Geobacter sulfurreducens of Fe(III) in synthetic arsenic-bearing schwertmannites has been investigated. During incubation at pH7, the rate of biological Fe(III) reduction increased with increasing initi... Read More about Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model (2012)
Journal Article
Rutter, A. V., Chippendale, T. W. E., Yang, Y., Španěl, P., Smith, D., & Sulé-Suso, J. (in press). Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, 138(1), 91-95. https://doi.org/10.1039/c2an36185j

Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2... Read More about Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model.

Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease (2012)
Journal Article
(2012). Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PloS one, e47169 -?. https://doi.org/10.1371/journal.pone.0047169

Primary cell transplantation is currently the gold standard for cell replacement in Parkinson's disease. However, the number of donors needed to treat a single patient is high, and the functional outcome is sometimes variable. The present work explor... Read More about Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease.

Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. (2012)
Journal Article
(2012). Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Research and Therapy, R204 - ?. https://doi.org/10.1186/ar4042

Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been associated with cardiovascular disease in th... Read More about Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis..

Antiepileptic drugs and the fetal epigenome (2012)
Journal Article
Emes, R. D., Clifford, H., Haworth, K. E., Farrell, W. E., Fryer, A. A., Carroll, W. D., …KM, I. (2013). Antiepileptic drugs and the fetal epigenome. Epilepsia, 54(1), e16-e19. https://doi.org/10.1111/j.1528-1167.2012.03673.x

Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was inves... Read More about Antiepileptic drugs and the fetal epigenome.

Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering (2012)
Journal Article
(2012). Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. Journal of Functional Biomaterials, 642 -687. https://doi.org/10.3390/jfb3030642

Corneal structure is highly organized and unified in architecture with structural and functional integration which mediates transparency and vision. Disease and injury are the second most common cause of blindness affecting over 10 million people wor... Read More about Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering.

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials (2012)
Journal Article
(2012). Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials. British journal of cancer, 1257-1267. https://doi.org/10.1038/bjc.2012.370

Background: The National Epirubicin Adjuvant Trial (NEAT) and BR9601 trials tested the benefit of epirubicin when added to cyclophosphamide, methotrexate and 5-fluorouracil (E-CMF) compared with standard CMF in adjuvant chemotherapy for women with e... Read More about Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.

Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. (2012)
Journal Article
Jordan. (2012). Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. BMC Health Services Research, 295 -?. https://doi.org/10.1186/1472-6963-12-295

BACKGROUND: Two of the commonest chronic diseases experienced by older people in the general population are cardiovascular diseases and osteoarthritis. These conditions also commonly co-occur, which is only partly explained by age. Yet, there have be... Read More about Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care..

Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. (2012)
Journal Article
Richardson, A., Stamelos, V., & Redman, C. (2012). Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. Journal of Molecular Signaling, 12 - ?. https://doi.org/10.1186/1750-2187-7-12

BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understanding the m... Read More about Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine..

Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine (2012)
Journal Article
(2012). Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine. Journal of Nanomaterials, https://doi.org/10.1155/2012/614094

Regenerative medicine is a pioneering field aimed at restoring and regenerating the function of damaged cells, organs and tissues in order to establish normal function. It demands the cross communication of disciplines to develop effective therapeuti... Read More about Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine.