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Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM (2014)
Journal Article
Deegan, A. J., Cinque, G., Wehbe, K., Konduru, S., & Yang, Y. (2015). Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Analytical and Bioanalytical Chemistry, 407(4), 1097-1105. https://doi.org/10.1007/s00216-014-8316-4

One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previo... Read More about Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM.

Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells (2014)
Journal Article
Malekigorji, M., Hoskins, C., Curtis, T., & Varbiro, G. Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells. Journal of Nanomedicine Research, 1(2), https://doi.org/10.15406/jnmr.2014.01.00010

Treatment of hepatocellular cancer with chemotherapeutic agents has limited success in clinical practice and their efficient IC50 concentration would require extremely high doses of drug administration which could not be tolerated due to systemic sid... Read More about Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells.

Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds (2014)
Journal Article
Hills, D., Mohseni, M., Dowler, J., Greenwood, I., Fielder, M., Pearson, R., & Perumal, D. (2014). Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds. Nitric Oxide: Biology and Chemistry, 42, 126. https://doi.org/10.1016/j.niox.2014.09.082

Nitric oxide, being a free radical, has a unique biological chemistry that since its elucidation as a signalling molecule in the cardiovascular system has been implicated in diverse biological functions ranging from insulin secretion, nociception and... Read More about Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds.

The role of drug transporters in the kidney: lessons from tenofovir (2014)
Journal Article
(2014). The role of drug transporters in the kidney: lessons from tenofovir. Frontiers in Pharmacology, https://doi.org/10.3389/fphar.2014.00248

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant ri... Read More about The role of drug transporters in the kidney: lessons from tenofovir.

'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care. (2014)
Journal Article
Chew-Graham, C. (2014). 'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care. Health Expectations, 1995 -2010. https://doi.org/10.1111/hex.12304

BACKGROUND: Health outcomes for long-term conditions (LTCs) can be improved by lifestyle, dietary and condition management-related behaviour change. Primary care is an important setting for behaviour change work. Practitioners have identified barrier... Read More about 'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care..

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.

Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs (2014)
Journal Article
Dunphy, S. E., Bratt, J. A., Akram, K. M., Forsyth, N. R., & El Haj, A. J. (2014). Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs. Journal of the Mechanical Behavior of Biomedical Materials, 38, 251-259. https://doi.org/10.1016/j.jmbbm.2014.04.005

In this study, collagen–elastin constructs were prepared with the aim of producing a material capable of mimicking the mechanical properties of a single alveolar wall. Collagen has been used in a wide range of tissue engineering applications; however... Read More about Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs.

Erratum (2014)
Journal Article
Di Leva, G. (2014). Erratum. JNCI: Journal of the National Cancer Institute, 106(11), dju373-dju373. https://doi.org/10.1093/jnci/dju373

This is a correction to: JNCI: Journal of the National Cancer Institute, Volume 106, Issue 12, December 2014, dju324, https://doi.org/10.1093/jnci/dju324 Erratum: “Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer,” Stefano Vol... Read More about Erratum.

Gonadotropin-releasing hormone (GnRH) analogues for premenstrual syndrome (PMS) (2014)
Journal Article
Naheed, B., Uthman, O. A., O'Mahony, F., Kuiper, J. H., & O'Brien, P. M. S. (2014). Gonadotropin-releasing hormone (GnRH) analogues for premenstrual syndrome (PMS). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.cd011330

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the therapeutic efficacy of GnRH agonists and antagonists in the management of PMS and PMDD.

Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. (2014)
Journal Article
(2014). Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. Analyst, 4903 - 4907. https://doi.org/10.1039/C4AN01102C

A novel, non-invasive technique is reported for determining the numbers of cells in a culture by quantifying dimethyl sulphide (DMS) in the culture headspace as produced by the cellular enzymatic reduction of dissolved dimethyl sulphoxide (DMSO). Mea... Read More about Counting cell number in situ by quantification of dimethyl sulphide in culture headspace..

The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy (2014)
Journal Article
Malekigorji, M., DM Curtis, A., & Hoskins, C. The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy. Journal of Nanomedicine Research, 1(1), https://doi.org/10.15406/jnmr.2014.01.00004

Over the last decade major advances have been made in the treatment of cancer such as breast and leukaemia. However, no satisfactory progress has been made in the effective treatment of pancreatic cancer. Treatment of this disease is hindered by resi... Read More about The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy.

Hip resurfacing arthroplasty : A new method to assess and quantify learning phase (2014)
Journal Article
AULAKH, T. S., JAYASEKERA, N., SINGH, R., PATEL, A., KUIPER, J. H., & RICHARDSON, J. B. (2014). Hip resurfacing arthroplasty : A new method to assess and quantify learning phase. Acta Orthopaedica Belgica, 80(3), 397-402

Hip resurfacing had initially gained acceptance and popularity as it helps preserve femoral bone stock. In this study we tried to answer the following questions ; 1. Whether there is a learning curve for hip resurfacing ? 2. Is it present in surgeons... Read More about Hip resurfacing arthroplasty : A new method to assess and quantify learning phase.

Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives (2014)
Journal Article
Aman, F., Hanif, M., Siddiqui, W. A., Ashraf, A., Filak, L. K., Reynisson, J., …Hartinger, C. G. (2014). Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives. Organometallics, 33(19), 5546-5553. https://doi.org/10.1021/om500825h

Oxicams are a versatile family of heterocyclic compounds, and the two representatives meloxicam and piroxicam are widely used drugs for the treatment of a variety of inflammatory and rheumatic diseases in humans. As cancer-associated inflammation is... Read More about Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives.

Bacterial distribution in the lungs of children with protracted bacterial bronchitis (2014)
Journal Article
Narang, R., Bakewell, K., Peach, J., Clayton, S., Samuels, M., Alexander, J., …Gilchrist, F. J. (2014). Bacterial distribution in the lungs of children with protracted bacterial bronchitis. PloS one, 9(9), Article e108523. https://doi.org/10.1371/journal.pone.0108523

OBJECTIVES: Flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is increasingly used for the microbiological confirmation of protracted bacterial bronchitis (PBB) in children with a chronic wet cough. At our centre, when performing FB-BAL for... Read More about Bacterial distribution in the lungs of children with protracted bacterial bronchitis.

Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction (2014)
Journal Article
Yadav, P., Marshall, A. J., Reynisson, J., Denny, W. A., Hay, M. P., & Anderson, R. F. (in press). Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction. Chemical Communications, 50(89), 13729-13731. https://doi.org/10.1039/c4cc05657d

The ˙OH radical is released from 3-trifluoromethyl-quinoxaline 1,4-dioxides upon one-electron reduction by cytochrome P450 oxidoreductase. This process effectively competes with back oxidation of the intermediate radical anion by oxygen and underlies... Read More about Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction.

A facile in vitro model to study rapid mineralization in bone tissues (2014)
Journal Article
Yang, Y. (2014). A facile in vitro model to study rapid mineralization in bone tissues. BioMedical Engineering OnLine, 136 - ?. https://doi.org/10.1186/1475-925X-13-136

BACKGROUND: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the fin... Read More about A facile in vitro model to study rapid mineralization in bone tissues.

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials (2014)
Journal Article
Xie, J., Jiang, J., Davoodi, P., Srinivasan, M., & Wang, C. (2015). Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials. Chemical Engineering Science, 125, 32-57. https://doi.org/10.1016/j.ces.2014.08.061

Electrohydrodynamic atomization (EHDA), also called electrospray technique, has been studied for more than one century. However, since 1990s it has begun to be used to produce and process micro-/nanostructured materials. Owing to the simplicity and f... Read More about Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials.

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy (2014)
Journal Article
Guilbert, M., Eklouh-Molinier, C., Wehbe, K., Sulé-Suso, J., Yang, Y., Cinque, G., …Sockalingum, G. D. (2014). Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. Journal of Biomedical Optics, 19(11), 111612. https://doi.org/10.1117/1.jbo.19.11.111612

We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analy... Read More about Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy.