All Outputs (101)

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives (2014)
Journal Article
Hung, J. M., Arabshahi, H. J., Leung, E., Reynisson, J., & Barker, D. (2014). Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives. European Journal of Medicinal Chemistry, 86, 420-437. https://doi.org/10.1016/j.ejmech.2014.09.001

Forty seven thieno[2,3-b]pyridines-2-carboxamides, furo[2,3-b]pyridines-2-carboxamides and tetrahydrothieno[2,3-b]quinolones-2-carboxamides derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. Th... Read More about Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives.

Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. (2014)
Journal Article
(2014). Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. Journal of Neurology, 1662 - 1676. https://doi.org/10.1007/s00415-013-7209-3

Neuro-Behçet's disease (NBD) is one of the more serious manifestations of Behçet's disease (BD), which is a relapsing inflammatory multisystem disease with an interesting epidemiology. Though NBD is relatively uncommon, being potentially treatable, n... Read More about Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations..

Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling (2014)
Journal Article
(2014). Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling. British Journal of Pharmacology, 3963-3979. https://doi.org/10.1111/bph.12604

The delivery of therapeutic agents is characterized by numerous challenges including poor absorption, low penetration in target tissues and non-specific dissemination in organs, leading to toxicity or poor drug exposure. Several nanomedicine strategi... Read More about Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling.

Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications (2014)
Journal Article
Céspedes, E., Byrne, J. M., Farrow, N., Moise, S., Coker, V. S., Bencsik, M., …Telling, N. D. (in press). Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications. Nanoscale, 6(21), 12958-12970. https://doi.org/10.1039/c4nr03004d

Magnetic hyperthermia uses AC stimulation of magnetic nanoparticles to generate heat for cancer cell destruction. Whilst nanoparticles produced inside magnetotactic bacteria have shown amongst the highest reported heating to date, these particles are... Read More about Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications.

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15 (2014)
Journal Article
Reader, K. L., Mottershead, D. G., Martin, G. A., Gilchrist, R. B., Heath, D. A., McNatty, K. P., & Juengel, J. L. (2016). Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15. Reproduction, Fertility and Development, 28(4), 491. https://doi.org/10.1071/rd14099

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Several non-Sma and mothers against decapentaplegic (SMAD) signal... Read More about Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles (2014)
Journal Article
Salas, G., Camarero, J., Cabrera, D., Takacs, H., Varela, M., Ludwig, R., …Teran, F. J. (2014). Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles. Journal of Physical Chemistry C, 118(34), 19985-19994. https://doi.org/10.1021/jp5041234

In the pursuit of controlling the heat exposure mediated by magnetic nanoparticles, we provide new guidelines for tailoring magnetic relaxation processes via dipolar interactions. For this purpose, highly crystalline and monodisperse magnetic iron ox... Read More about Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles.

Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer. Rapid communications in mass spectrometry RCM, 1683 - 1690. https://doi.org/10.1002/rcm.6947

RATIONALE: The reactions of NO(+) with volatile organic compounds (VOCs) in Selective Reagent Ionization Time-of-Flight Mass Spectrometry (SRI-TOF-MS) reactors are relatively poorly known, inhibiting their use for trace gas analysis. The rationale fo... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer.

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication (2014)
Journal Article
(2014). A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication. Journal of Antimicrobial Chemotherapy, 3275-3281. https://doi.org/10.1093/jac/dku312

Objectives Recent clinical data have suggested high raltegravir concentrations in gut tissue after oral administration, with implications for treatment and prevention. We have used in silico, in vitro, ex vivo and in vivo models to further investiga... Read More about A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication.

Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis (2014)
Journal Article
Mamas. (2014). Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis. Open Heart, e000092 -?. https://doi.org/10.1136/openhrt-2014-000092

OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of renal denervation in patients with resistant hypertension. METHODS: We searched MEDLINE and EMBASE for studies that evaluated the use of catheter-based renal sympathetic... Read More about Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis.

Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges (2014)
Journal Article
Jenkins, S., Yiu, H., Rosseinsky, M., & Chari, D. (2014). Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Molecular and Cellular Therapies, https://doi.org/10.1186/2052-8426-2-23

Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin - the protective sheath around nerve fibers. While clinical tr... Read More about Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists (2014)
Journal Article
McCoull, W., Barton, P., Brown, A. J., Bowker, S. S., Cameron, J., Clarke, D. S., …Morgan, D. (2014). Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. Journal of Medicinal Chemistry, 57(14), 6128 - 6140

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identif... Read More about Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article
Mottershead. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PloS one, https://doi.org/10.1371/journal.pone.0103563

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014)
Journal Article
Chen, R. L., Ogunshola, O. O., Yeoh, K. K., Jani, A., Papadakis, M., Nagel, S., …Buchan, A. M. (2014). HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice. Journal of Neurochemistry, 131(2), 177-189. https://doi.org/10.1111/jnc.12804

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebra... Read More about HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study (2014)
Journal Article
(2014). Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study. BMJ Open, e005429 -?. https://doi.org/10.1136/bmjopen-2014-005429

OBJECTIVES: The study investigated (1) the association between comorbidity and multidrug prescribing compared with the index condition, and (2) the association between vascular comorbidity and non-vascular condition key drug prescribing. DESIGN: Cros... Read More about Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study.

Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice (2014)
Journal Article
Kehoe, O., Kalia, N., King, S., Eustace, A., Middleton, J., Boyes, C., …Patterson, A. (2014). Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice. Arthritis Research and Therapy, R148 -?. https://doi.org/10.1186/ar4610

INTRODUCTION: Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficki... Read More about Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice.

Using Fourier transform IR spectroscopy to analyze biological materials (2014)
Journal Article
Baker, M. J., Trevisan, J., Bassan, P., Bhargava, R., Butler, H. J., Dorling, K. M., …Martin, F. L. (2014). Using Fourier transform IR spectroscopy to analyze biological materials. Nature Protocols, 9(8), 1771-1791. https://doi.org/10.1038/nprot.2014.110

IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative, label-free extraction of biochemical information and images toward diagnosis and the assessment of cell functionality. Although not strictly microscopy in... Read More about Using Fourier transform IR spectroscopy to analyze biological materials.

Mouse GDF9 decreases KITL gene expression in human granulosa cells (2014)
Journal Article
Tuck, A. R., Mottershead, D. G., Fernandes, H. A., Norman, R. J., Tilley, W. D., Robker, R. L., & Hickey, T. E. (2015). Mouse GDF9 decreases KITL gene expression in human granulosa cells. Endocrine, 48(2), 686-695. https://doi.org/10.1007/s12020-014-0335-6

Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothes... Read More about Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients (2014)
Journal Article
(2014). Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients. Critical Care, R137 - ?. https://doi.org/10.1186/cc13958

INTRODUCTION: Neutrophil gelatinase-associated lipocalin (NGAL) has been demonstrated to be a useful early diagnostic biomarker of acute kidney injury (AKI) where the timing of the insult is certain. However, NGAL is not well validated in adult criti... Read More about Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients.

Real-time simulation of three-dimensional shoulder girdle and arm dynamics (2014)
Journal Article
(2014). Real-time simulation of three-dimensional shoulder girdle and arm dynamics. IEEE Transactions on Biomedical Engineering, 1947 - 1956. https://doi.org/10.1109/TBME.2014.2309727

Electrical stimulation is a promising technology for the restoration of arm function in paralyzed individuals. Control of the paralyzed arm under electrical stimulation, however, is a challenging problem that requires advanced controllers and command... Read More about Real-time simulation of three-dimensional shoulder girdle and arm dynamics.

Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation (2014)
Journal Article
Romano, G., Acunzo, M., Garofalo, M., Di Leva, G., Cascione, L., Zanca, C., …Croce, C. M. (2014). Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation. Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10389-10389. https://doi.org/10.1073/pnas.1410423111

CELL BIOLOGY Correction for “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation,” by Giulia Romano, Mario Acunzo, Michela Garofalo, Gianpiero Di Leva, Luciano Cascione, Ciro... Read More about Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation.