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Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA). (2018)
Journal Article
Slater, N., White, S., Venables, R., & Frisher, M. (2018). Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA). BMJ Open, 8(3), Article e020270. https://doi.org/10.1136/bmjopen-2017-020270

OBJECTIVES: While older age and ill health are known to be associated with polypharmacy, this paper aims to identify whether wealth, body mass index (BMI), smoking and alcohol consumption are also associated with polypharmacy (5-9 prescribed medicati... Read More about Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA)..

Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. (2018)
Journal Article
Tabinor, M., Elphick, E., Dudson, M., Shing Kwok, C., Lambie, M., & Davies, S. J. (2018). Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. Scientific reports, 8, Article 4441. https://doi.org/10.1038/s41598-018-21226-y

Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in whi... Read More about Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis..

Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study (2018)
Journal Article
Cao, P., Yang, Y., Ijeoma Uche, F., Ruth Hart, S., Li, W., & Yuan, C. (2018). Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study. International Journal of Molecular Sciences, 793 - 793. https://doi.org/10.3390/ijms19030793

Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola p... Read More about Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study.

Loss of miR-204 expression is a key event in melanoma (2018)
Journal Article
Galasso, M., Morrison, C., Minotti, L., Corrà, F., Zerbinati, C., Agnoletto, C., …Volinia, S. (2018). Loss of miR-204 expression is a key event in melanoma. Molecular cancer, 17, Article 71. https://doi.org/10.1186/s12943-018-0819-8

Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance: miR-200a/b/c, miR-203, miR-205, miR-204, miR-211, miR-23b a... Read More about Loss of miR-204 expression is a key event in melanoma.

Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury (2018)
Journal Article
(2018). Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury. Environmental Toxicology and Pharmacology, 82-86. https://doi.org/10.1016/j.etap.2018.03.007

In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expression of CatSper genes, sperm... Read More about Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury.

Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Cao, P., Li, W., Morris, A. R., Horrocks, P. D., Yuan, C., & Yang, Y. (2018). Investigation of the antibiofilm capacity of peptide-modified stainless steel. Royal Society Open Science, https://doi.org/10.1098/rsos.172165

Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.

Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort (2018)
Journal Article
Mamas. (2018). Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Medicine, e1002501. https://doi.org/10.1371/journal.pmed.1002501

Background There is limited knowledge of the scale and impact of multimorbidity for patients who have had an acute myocardial infarction (AMI). Therefore, this study aimed to determine the extent to which multimorbidity is associated with long-term... Read More about Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort.

Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database (2018)
Journal Article
Mamas, M., & Nolan, J. (2018). Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database. JACC. Cardiovascular interventions, 482-492. https://doi.org/10.1016/j.jcin.2017.12.020

Objectives Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, access site choice and outcomes of patients undergoing PCI with previous coronary artery bypass grafting (CABG) were studied. Back... Read More about Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database.

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. (2018)
Journal Article
(2018). Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. Journal of Biomedical Materials Research Part A, 629 - 640. https://doi.org/10.1002/jbm.a.36267

Topographical and mechanical cues are vital for cell fate, tissue development in vivo, and to mimic the native cell growth environment in vitro. To date, the combinatory effect of mechanical and topographical cues as not been thoroughly investigated.... Read More about Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration..

Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression (2018)
Journal Article
Moss. (2018). Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology, 361-373. https://doi.org/10.1111/jphp.12863

Objectives The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters. Methods Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evoluti... Read More about Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression.

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy (2018)
Journal Article
Yang. (2018). Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, 126-133. https://doi.org/10.1016/j.ymeth.2017.10.010

Cell mechanical behaviour is increasingly recognised as a central biophysical parameter in cancer and stem cell research, and methods of investigating their mechanical behaviour are therefore needed. We have developed a novel qualitative method based... Read More about Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.

Consumer segmentation and time interval between types of hospital admission: a clinical linkage database study (2018)
Journal Article
(2018). Consumer segmentation and time interval between types of hospital admission: a clinical linkage database study. Journal of Public Health, 154-162. https://doi.org/10.1093/pubmed/fdx028

Background: Healthcare policies target unplanned hospital admissions and 30-day re-admission as key measures of efficiency, but do not focus on factors that influence trajectories of different types of admissions in the same patient over time. Object... Read More about Consumer segmentation and time interval between types of hospital admission: a clinical linkage database study.

The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery (2018)
Journal Article
(2018). The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology and Hepatology, 223-236. https://doi.org/10.1080/17474124.2018.1399794

Introduction Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being... Read More about The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery.

Tenogenic differentiation of human embryonic stem cells (2018)
Journal Article
Dale, T. P., Mazher, S., Webb, W. R., Zhou, J., Maffulli, N., Chen, G., …Forsyth, N. R. (2018). Tenogenic differentiation of human embryonic stem cells. Tissue engineering. Part A, 24(5-6), 361-368. https://doi.org/10.1089/ten.TEA.2017.0017

Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hE... Read More about Tenogenic differentiation of human embryonic stem cells.

Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. (2018)
Journal Article
Bishop, J., Sim, J., Penaloza, C., Jowett, S., Gray, R., Ferdinand, P., …Roffe, C. (2018). Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. Health Technology Assessment, 22(14), 1 - 88. https://doi.org/10.3310/hta22140

BACKGROUND: Stroke is a major cause of death and disability worldwide. Hypoxia is common after stroke and is associated with worse outcomes. Oxygen supplementation could prevent hypoxia and secondary brain damage. OBJECTIVES: (1) To assess whether or... Read More about Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT..

United Kingdom Catheter Study - Protocol Synopsis. (2018)
Journal Article
Briggs, V., Solis-Trapala, I., Wailloo, A., McCulloch, K., Lambie, M., Caskey, F., …Wilkie, M. (2018). United Kingdom Catheter Study - Protocol Synopsis. https://doi.org/10.3747/pdi.2017.00083

BACKGROUND: High-quality peritoneal dialysis (PD) catheter insertion pathways are essential for optimal access to the therapy. Dialysis outcomes are influenced by a range of patient and center-related factors, and there is a need to better understand... Read More about United Kingdom Catheter Study - Protocol Synopsis..

The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization (2018)
Journal Article
Chong, A., Lo, T., George, S., Ratib, K., Mamas, M., & Nolan, J. (2018). The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization. Cardiovascular Revascularization Medicine, 19(2), 163-167. https://doi.org/10.1016/j.carrev.2017.07.016

Background The radial artery is increasingly used for cardiac procedures, but is a relatively small vessel that is prone to spasm when instrumented. Intra-arterial nitroglycerine has been shown to reduce radial spasm but first requires arterial acce... Read More about The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Mbye, H., Richardson, A., Li, W., Horrocks, P., Johnson-Ajinwo, O., & Ullah, I. (2018). The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2018.02.051

Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study (2018)
Journal Article
Al-Tamimi, N., Slater, N., Kayyali, R., & ElShaer, A. (2019). Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study. Canadian Journal of Diabetes, 43(1), 27-33. https://doi.org/10.1016/j.jcjd.2018.02.005

Objective Intensive self-monitoring of blood glucose levels by patients with diabetes achieves optimal glucose control, hence reducing the likelihood of complications. Methods This is a prospective, cross-sectional study targeting adults with di... Read More about Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study.