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Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis (2018)
Journal Article
Mamas. (2018). Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis. BMC Medicine, https://doi.org/10.1186/s12916-017-0996-0

Background Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic conditions and primary medical... Read More about Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis.

Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc? (2018)
Journal Article
Brown, S., Matta, A., Gruber, H., Hanley, E., Erwin, M., Roberts, S., …Melrose, J. (2018). Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?. Stem Cells and Development, 147 -165. https://doi.org/10.1089/scd.2017.0213

The aim of this study was to examine the complexity of the stem cell populations in the intervertebral disc (IVD) and understand their role in disc degeneration, with a view of determining whether the resident stem cells could be developed for therap... Read More about Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?.

The twin peg Oxford knee — Medium term survivorship and surgical principles (2018)
Journal Article
Kuiper. (2018). The twin peg Oxford knee — Medium term survivorship and surgical principles. https://doi.org/10.1016/j.knee.2018.01.001

A multicentre study of single peg Oxford knees reported failure associated with osteoarthritis progression, femoral component loosening, unexplained pain and meniscal bearing dislocation. Suboptimally positioned femoral components and intraoperative... Read More about The twin peg Oxford knee — Medium term survivorship and surgical principles.

Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience. (2018)
Journal Article
Ogrodnik, P., & McBride, A. (2018). Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience. Orthopaedic and Trauma Times, 19 - 27

This paper presents the Royal Stoke University Hospital pin-site care protocol. It has evolved during 25 years of fracture management research at the centre and has been developed in accordance with the RCN Consensus Guidelines on Pin-Site Care. Howe... Read More about Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience..

A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. (2018)
Journal Article
Al-Mayyahi, R. S., Sterio, L. D., Connolly, J. B., Adams, C., Al-Tumah, W. A., Sen, J., …Chari, D. (2018). A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. Molecular and Cellular Neuroscience, 86, 30-40. https://doi.org/10.1016/j.mcn.2017.11.006

Corticosteroids (CSs) are widely used clinically, for example in pediatric respiratory distress syndrome, and immunosuppression to prevent rejection of stem cell transplant populations in neural cell therapy. However, such treatment can be associated... Read More about A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells..

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy (2018)
Journal Article
(2018). Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Scientific reports, 8:1898 - 8:1898. https://doi.org/10.1038/s41598-018-20287-3

It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000?CpGs) and gene expression analysis after muscle hypertrophy (loadin... Read More about Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.

A Review On The Effects Of Chemotherapy Drugs And Cooling Alone Or In Combination On The Cell Cycle (2018)
Journal Article
(2018). A Review On The Effects Of Chemotherapy Drugs And Cooling Alone Or In Combination On The Cell Cycle. https://doi.org/10.21275/ART20179577

When it comes to cell proliferation, this is a process strictly controlled by extracellular signals, such as nutrients, growth factors, temperature, and more. Together, these establish the cell cycle control mechanism, which is the core of cell proli... Read More about A Review On The Effects Of Chemotherapy Drugs And Cooling Alone Or In Combination On The Cell Cycle.

Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR? receptor. (2018)
Journal Article
(2018). Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR? receptor. Journal of Neuroinflammation, 19 - ?. https://doi.org/10.1186/s12974-018-1060-5

BACKGROUND: Neuroprotection with cannabinoids in Parkinson's disease (PD) has been afforded predominantly with antioxidant or anti-inflammatory cannabinoids. In the present study, we investigated the anti-inflammatory and neuroprotective properties o... Read More about Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR? receptor..

Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance (2018)
Journal Article
Curtis, A., Kumar, M., & Hoskins, C. (2018). Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10010011

Anti-microbial resistance is a growing problem that has impacted the world and brought about the beginning of the end for the old generation of antibiotics. Increasingly, more antibiotics are being prescribed unnecessarily and this reckless practice... Read More about Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance.

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents (2018)
Journal Article
Reynisson, J. (2018). Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules, https://doi.org/10.3390/molecules23010145

It is now established that the thieno[2,3-b]pyridines are a potent class of antiproliferatives. One of the main issues encountered for their clinical application is their low water solubility. In order to improve this, two strategies were pursued. Fi... Read More about Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database (2018)
Journal Article
Mamas. (2018). Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database. American Heart Journal, 46-54. https://doi.org/10.1016/j.ahj.2018.01.001

Aims Access site choice for cases requiring rotational atherectomy (PCI-ROTA) is poorly defined. Using the British Cardiovascular Intervention Society PCI database, temporal changes and contemporary associates/outcomes of access site choice for PCI-... Read More about Temporal changes in radial access use, associates and outcomes in patients undergoing PCI using rotational atherectomy between 2007 and 2014: results from the British Cardiovascular Intervention Society national database.

A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention (2018)
Journal Article
(2018). A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention. Oncologist, 84 -96. https://doi.org/10.1634/theoncologist.2017-0263

Chemotherapy-induced alopecia (CIA) is the most visibly distressing side effect of commonly administered chemotherapeutic agents. Because psychological health has huge relevance to lifestyle, diet, and self-esteem, it is important for clinicians to f... Read More about A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention.

Remote regulation of magnetic particle targeted Wnt signalling for bone tissue engineering (2018)
Journal Article
(2018). Remote regulation of magnetic particle targeted Wnt signalling for bone tissue engineering. Nanomedicine: Nanotechnology, Biology and Medicine, 173-184. https://doi.org/10.1016/j.nano.2017.09.008

Wnt signaling is critically involved in the differentiation of human Mesenchymal Stem Cells (hMSC). Wnt proteins therefore have considerable therapeutic value, but are expensive and difficult to produce. UM206 is a synthetic peptide and ligand for th... Read More about Remote regulation of magnetic particle targeted Wnt signalling for bone tissue engineering.

Investigating Heterogeneity of Effects and Associations Using Interaction Terms (2018)
Journal Article
Mamas. (2018). Investigating Heterogeneity of Effects and Associations Using Interaction Terms. Journal of Clinical Epidemiology, 79-83. https://doi.org/10.1016/j.jclinepi.2017.09.012

Effect heterogeneity, the variability of an association or exposure across subgroups, usually warrants further investigation. The aim of this deeper analysis is to identify effect modifiers (or moderators) and quantify their relationship with the exp... Read More about Investigating Heterogeneity of Effects and Associations Using Interaction Terms.