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The Oswestry-Bristol Classification. (2019)
Journal Article
Kuiper. (2019). The Oswestry-Bristol Classification. The Bone & Joint Journal, 102 - 107. https://doi.org/10.1302/0301-620X.102B1.BJJ-2019-0366.R3

AIMS: Trochlear dysplasia is a significant risk factor for patellofemoral instability. The Dejour classification is currently considered the standard for classifying trochlear dysplasia, but numerous studies have reported poor reliability on both pla... Read More about The Oswestry-Bristol Classification..

Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin (2019)
Journal Article
Yang. (2019). Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2019.101496

Besifloxacin hydrochloride (BSF) is a new ophthalmic antibiotic. However, its low water solubility limits its therapeutic efficacy. This article reported a novel lipid based drug delivery system to enhance ocular bioavailability of BSF. Cationic nano... Read More about Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin.

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy (2019)
Journal Article
Reynisson. (2019). Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21010126

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (To... Read More about Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

If it's 'only' asthma, why are children still dying? (2019)
Journal Article
(2019). If it's 'only' asthma, why are children still dying?. Archives of Disease in Childhood, 494 - 498. https://doi.org/10.1136/archdischild-2019-318215

Outcomes for children with asthma in the UK continue to lag behind other European countries. Mortality remains unacceptably high and in contrast to adults with asthma, most deaths occur in the 1 in 20 children with asthma who have severe asthma. Desp... Read More about If it's 'only' asthma, why are children still dying?.

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial (2019)
Journal Article
Schmid, P., Abraham, J., Chan, S., Wheatley, D., Murray Brunt, A., Nemsadze, G., …C. Turner, N. (2020). Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial. Journal of Clinical Oncology, 38(5), 423 - 433. https://doi.org/10.1200/JCO.19.00368

PURPOSE: The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is frequently activated in triple-negative breast cancer (TNBC). The AKT inhibitor capivasertib has shown preclinical activity in TNBC models, and drug sensitivity has been assoc... Read More about Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.

Virtual patient technology to educate pharmacists and pharmacy students on patient communication: a systematic review (2019)
Journal Article
Richardson, C. L., White, S., & Chapman, S. (2019). Virtual patient technology to educate pharmacists and pharmacy students on patient communication: a systematic review. BMJ Simulation and Technology Enhanced Learning, 332 - 338. https://doi.org/10.1136/bmjstel-2019-000514

Background Virtual patients (VPs) are a sub-type of healthcare simulation that have been underutilised in health education. Their use is increasing, but applications are varied, as are designs, definitions and evaluations. Previous reviews have been... Read More about Virtual patient technology to educate pharmacists and pharmacy students on patient communication: a systematic review.

How to quickly critically appraise a randomized control trial (2019)
Journal Article
(2019). How to quickly critically appraise a randomized control trial. Paediatrics and Child Health, 57-59. https://doi.org/10.1016/j.paed.2019.11.004

Being able to critically appraise scientific papers is an important skill. A thorough and methodical approach is necessary, particularly for peer-review purposes. However, it is also important to be able to do this quickly and efficiently. In some ci... Read More about How to quickly critically appraise a randomized control trial.

Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. (2019)
Journal Article
Gilchrist. (2019). Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. BMJ Paediatrics Open, https://doi.org/10.1136/bmjpo-2019-000572

Background: Nusinersen has been used to treat spinal muscular atrophy type 1 (SMA1) in the UK since 2017. While initial trials showed neuromuscular benefit from treating SMA1, there is little information on the respiratory effects of nusinersen. We a... Read More about Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review..

Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. (2019)
Journal Article
Reynisson. (2019). Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. Journal of Medicinal Chemistry, 334-348. https://doi.org/10.1021/acs.jmedchem.9b01694

Cell-penetrating peptide conjugated peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and synergistic action in combination with cisplatin and amphotericin B against cancer and fungal cells, respectively. Ta... Read More about Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations..

Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity (2019)
Journal Article
Watson. (2019). Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity. Biochemical and Biophysical Research Communications, 231-236. https://doi.org/10.1016/j.bbrc.2019.09.124

Pro-inflammatory cytokines contribute to pancreatic beta cell death in the pathogenesis of type 1 diabetes mellitus (DM). Cytochrome P450-derived epoxyeicosatrienoic acids (EETs), produced by selective epoxidation of arachidonic acid, display anti-in... Read More about Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity.

Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening (2019)
Journal Article
Jinsakul, N., Tsai, C., Tsai, C., & Wu, P. (2019). Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening. Mathematics, 7(12), Article 1170. https://doi.org/10.3390/math7121170

One of the leading forms of cancer is colorectal cancer (CRC), which is responsible for increasing mortality in young people. The aim of this paper is to provide an experimental modification of deep learning of Xception with Swish and assess the poss... Read More about Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening.

P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (2019)
Journal Article
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(Suppl 1), S43-S43. https://doi.org/10.2991/artres.k.191224.036

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the pr... Read More about P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection.

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. (2019)
Journal Article
Reynisson. (2019). Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorganic and Medicinal Chemistry, 115234 - ?. https://doi.org/10.1016/j.bmc.2019.115234

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced w... Read More about Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening..

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening (2019)
Journal Article
Reynisson. (2019). Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. Molecules, https://doi.org/10.3390/molecules24234346

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients' immune systems, leading to poor disease outcomes.... Read More about Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. (2019)
Journal Article
Reynisson. (2019). Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. European Journal of Medicinal Chemistry, 111919 - ?. https://doi.org/10.1016/j.ejmech.2019.111919

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits... Read More about Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents..