All Outputs (1775)

Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease (2012)
Journal Article
(2012). Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PloS one, e47169 -?. https://doi.org/10.1371/journal.pone.0047169

Primary cell transplantation is currently the gold standard for cell replacement in Parkinson's disease. However, the number of donors needed to treat a single patient is high, and the functional outcome is sometimes variable. The present work explor... Read More about Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease.

Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. (2012)
Journal Article
(2012). Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Research and Therapy, R204 - ?. https://doi.org/10.1186/ar4042

Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been associated with cardiovascular disease in th... Read More about Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis..

Antiepileptic drugs and the fetal epigenome (2012)
Journal Article
Emes, R. D., Clifford, H., Haworth, K. E., Farrell, W. E., Fryer, A. A., Carroll, W. D., …KM, I. (2013). Antiepileptic drugs and the fetal epigenome. Epilepsia, 54(1), e16-e19. https://doi.org/10.1111/j.1528-1167.2012.03673.x

Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was inves... Read More about Antiepileptic drugs and the fetal epigenome.

Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering (2012)
Journal Article
(2012). Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. Journal of Functional Biomaterials, 642 -687. https://doi.org/10.3390/jfb3030642

Corneal structure is highly organized and unified in architecture with structural and functional integration which mediates transparency and vision. Disease and injury are the second most common cause of blindness affecting over 10 million people wor... Read More about Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering.

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials (2012)
Journal Article
(2012). Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials. British journal of cancer, 1257-1267. https://doi.org/10.1038/bjc.2012.370

Background: The National Epirubicin Adjuvant Trial (NEAT) and BR9601 trials tested the benefit of epirubicin when added to cyclophosphamide, methotrexate and 5-fluorouracil (E-CMF) compared with standard CMF in adjuvant chemotherapy for women with e... Read More about Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.

Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. (2012)
Journal Article
Jordan. (2012). Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. BMC Health Services Research, 295 -?. https://doi.org/10.1186/1472-6963-12-295

BACKGROUND: Two of the commonest chronic diseases experienced by older people in the general population are cardiovascular diseases and osteoarthritis. These conditions also commonly co-occur, which is only partly explained by age. Yet, there have be... Read More about Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care..

Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. (2012)
Journal Article
Richardson, A., Stamelos, V., & Redman, C. (2012). Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. Journal of Molecular Signaling, 12 - ?. https://doi.org/10.1186/1750-2187-7-12

BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understanding the m... Read More about Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine..

Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine (2012)
Journal Article
(2012). Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine. Journal of Nanomaterials, https://doi.org/10.1155/2012/614094

Regenerative medicine is a pioneering field aimed at restoring and regenerating the function of damaged cells, organs and tissues in order to establish normal function. It demands the cross communication of disciplines to develop effective therapeuti... Read More about Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine.

Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis (2012)
Journal Article
Akram, K. M., Lomas, N. J., Spiteri, M. A., & Forsyth, N. R. (2013). Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis. European Respiratory Journal, 41(3), 683-694. https://doi.org/10.1183/09031936.00213411

Club cells (Clara cells) participate in bronchiolar wound repair and regeneration. Located in the bronchioles, they become activated during alveolar injury in idiopathic pulmonary fibrosis (IPF) and migrate into the affected alveoli, a process called... Read More about Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis.

Gene expression of single human mesenchymal stem cell in response to fluid shear (2012)
Journal Article
(2012). Gene expression of single human mesenchymal stem cell in response to fluid shear. Journal of Tissue Engineering, 1-8. https://doi.org/10.1177/2041731412451988

Stem cell therapy may rely on delivery and homing through the vascular system to reach the target tissue. An optical tweezer model has been employed to exert different levels of shear stress on a single non-adherent human bone marrow-derived mesenchy... Read More about Gene expression of single human mesenchymal stem cell in response to fluid shear.

Divalent metals and pH alter raltegravir disposition in vitro (2012)
Journal Article
(2012). Divalent metals and pH alter raltegravir disposition in vitro. Antimicrobial Agents and Chemotherapy, 3020-3026. https://doi.org/10.1128/AAC.06407-11

Raltegravir shows marked pharmacokinetic variability in patients, with gastrointestinal pH and divalent-metal binding being potential factors. We investigated raltegravir solubility, lipophilicity, pKa, and permeativity in vitro to elucidate known in... Read More about Divalent metals and pH alter raltegravir disposition in vitro.

The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients (2012)
Journal Article
(2012). The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients. Respiratory Medicine, https://doi.org/10.1136/bmjopen-2012-001030

Objective To improve the understanding of the determinants of prognosis and accurate risk stratification in community-acquired pneumonia (CAP). Design Multicentre collaboration of prospective cohorts. Setting 6 cohorts from the USA, Canada, Hon... Read More about The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients.

Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. (2012)
Journal Article
(2012). Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. Journal of Neurotrauma, 1614 - 1625. https://doi.org/10.1089/neu.2011.2109

Mesenchymal stem cells (MSC) derived from bone marrow can potentially reduce the acute inflammatory response in spinal cord injury (SCI) and thus promote functional recovery. However, the precise mechanisms through which transplanted MSC attenuate in... Read More about Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury..

Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD (2012)
Journal Article
COKER, V. S., BYRNE, J. M., TELLING, N. D., VAN DER LAAN, G., LLOYD, J. R., HITCHCOCK, A. P., …PATTRICK, R. A. D. (2012). Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD. Geobiology, 10(4), 347-354. https://doi.org/10.1111/j.1472-4669.2012.00329.x

A combination of scanning transmission X-ray microscopy and X-ray magnetic circular dichroism was used to spatially resolve the distribution of different carbon and iron species associated with Shewanella oneidensis MR-1 cells. S. oneidensis MR-1 cou... Read More about Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD.

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. (2012)
Journal Article
Di Leva. (2012). Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Molecular Oncology, 458 - 472. https://doi.org/10.1016/j.molonc.2012.03.003

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA l... Read More about Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer..

Orthopaedic applications of nanoparticle-based stem cell therapies (2012)
Journal Article
(2012). Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Research and Therapy, 13 - ?. https://doi.org/10.1186/scrt104

Stem cells have tremendous applications in the field of regenerative medicine and tissue engineering. These are pioneering fields that aim to create new treatments for disease that currently have limited therapies or cures. A particularly popular ave... Read More about Orthopaedic applications of nanoparticle-based stem cell therapies.

Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study (2012)
Journal Article
(2012). Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Research and Therapy, R81 -?. https://doi.org/10.1186/ar3804

Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine that plays important roles in immunity and inflammation. Some studies have suggested that polymorphism in the TGFB1 gene is associated with heart disease in the general population... Read More about Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.

The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism (2012)
Journal Article
(2012). The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism. Journal of Nanobiotechnology, https://doi.org/10.1186/1477-3155-10-15

Background: Iron oxide magnetic nanoparticles (MNP’s) have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or ef... Read More about The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism.

Global impact of asthma on children and adolescents' daily lives: the room to breathe survey (2012)
Journal Article
(2012). Global impact of asthma on children and adolescents' daily lives: the room to breathe survey. Pediatric Pulmonology, 346-357. https://doi.org/10.1002/ppul.21557

Objective To establish children and adolescents' perspectives regarding their asthma and its impact upon their daily lives. Design A 14-item questionnaire. Setting Canada, Greece, Hungary, The Netherlands, the United Kingdom, and South Afric... Read More about Global impact of asthma on children and adolescents' daily lives: the room to breathe survey.

Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15 (2012)
Journal Article
(2012). Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Molecular Human Reproduction, 121 - 128

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for normal fertility. Both of these proteins are members of the transforming growth factor beta... Read More about Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.