All Outputs (8)

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. (2022). Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

Remote control healing for osteoarthritis repair (2022)
Thesis
Echevarria, I. (2022). Remote control healing for osteoarthritis repair. (Thesis). Keele University

Articular cartilage is a key tissue for the normal functioning of the joints, with a trend for degradation with aging and physical activity. The lack of vascularisation hinders the self-repair, and often a scar tissue replaces the damaged cartilage,... Read More about Remote control healing for osteoarthritis repair.

Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England (2022)
Thesis
Thayer, N. M. (2022). Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England. (Thesis). Keele University

In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services. A literature revi... Read More about Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England.

Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke (2022)
Thesis
Singh, A. (2022). Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke. (Thesis). Keele University

Ischaemic stroke is the most common form of stroke, accounting for appropriate 87% of all strokes. Reperfusion is the only immediate treatment option following ischaemic stroke, however, this option is only applicable to a small percentage of patient... Read More about Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke.

A multimodal approach to biomarker discovery for spinal cord injury (2022)
Thesis
Bernardo Harrington, G. M. (2022). A multimodal approach to biomarker discovery for spinal cord injury. (Thesis). Keele University

The extent of the devastating outcomes following spinal cord injury, particularly with respect to neurological function, are difficult to predict. This can make it difficult to plan clinical care and manage patient expectations, both of which can hav... Read More about A multimodal approach to biomarker discovery for spinal cord injury.

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. (2022). A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.

Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD) (2022)
Thesis
Scott, N. (2022). Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD). (Thesis). Keele University

Objectives: Observational studies of polypharmacy and the risk of death or ischaemic stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings. The reason for this variation may be due to differences in study designs and... Read More about Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD).

Use of nanoparticles to improve the therapeutic index of navitoclax (2022)
Thesis
Alrosan, K. J. J. A. (2022). Use of nanoparticles to improve the therapeutic index of navitoclax. (Thesis). Keele University

Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of t... Read More about Use of nanoparticles to improve the therapeutic index of navitoclax.