All Outputs (185)

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417500

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417395

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417176

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.

Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum (2020)
Thesis
Famodimu, M. T. Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417173

The emergence of P. falciparum resistant to current front-line artemisinin combination therapies underscores the urgent demand for new candidate molecules for a single exposure radical cure and prophylaxis drug. Developing a suitable candidate compon... Read More about Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417183

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis (2020)
Thesis
Kirkby, M. Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417188

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide that has been used extensively for the past half century as a topical antiseptic, due to its ability to effectively kill surface bacteria with minimal reports of resistance. However, bacteria... Read More about Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis.

Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer (2020)
Thesis
Ali Asgari, M. Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417192

Pancreatic cancer is the 4th most aggressive cancer in the Western world. There are very little drugs available as chemotherapies for the treatment of pancreatic cancer. Of the ones used, most of them become eliminated by first pass metabolism before... Read More about Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer.

An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research (2020)
Thesis
Shenton, J. J. L. An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417292

Background
Research in the NHS is essential to provide evidence to improve services and patient outcomes. The Government’s continued commitment to research has been made clear through the inclusion of research in key NHS policy documents including t... Read More about An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research.

Human cell therapies in preclinical and clinical studies of cartilage repair (2020)
Thesis
Perry, J. K. L. Human cell therapies in preclinical and clinical studies of cartilage repair. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417295

Cell therapy offers potential to repair and regenerate damaged tissues. An established example of its use in the clinic is for treating cartilage defects. This thesis addresses this topic, both studying the use of imaging in such patients having had... Read More about Human cell therapies in preclinical and clinical studies of cartilage repair.

Development of a novel doxorubicin delivery system for pancreatic cancer (2020)
Thesis
Al-Ameri, J. J. M. Development of a novel doxorubicin delivery system for pancreatic cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416228

Pancreatic cancer is considered as the 4th most aggressive cancer in the Western world. There is a direct link between
pancreatic cancer diagnosis and patient age with high occurrence of the disease happening in the 65-75-year age group. The majori... Read More about Development of a novel doxorubicin delivery system for pancreatic cancer.

Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation (2020)
Thesis
Berry, J. D. Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416230

Interprofessional education (IPE) has been proposed as a method of creating a collaborative practice ready workforce in healthcare. Postulated benefits of the technique include improving communication between professional groups, which in turn should... Read More about Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation.

Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease (2020)
Thesis
Gómez Gálvez, Y. Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416558

The degeneration of dopaminergic neurons (DAn) in the midbrain substantia nigra pars compacta (SNpc) is a definitive feature of Parkinson's disease (PD). Although age has been established as one of the main risk factors, the role that ageing has in t... Read More about Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease.

An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering (2020)
Thesis
Foster, N. C. An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416573

Articular cartilage is prone to degradation as a result of aging, disease and injury, which can lead to the onset of osteoarthritis (OA). The avascular nature of the tissue renders its endogenous repair capacity notoriously poor and its aneural natur... Read More about An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering.

Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core (2020)
Thesis
Jihad, T. W. J. Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416566

Calix[4]resorcinarenes functionalised with glycosidic ligands on their lower rim have received little interest compared to analogues bearing carbohydrates on the upper rim. In this study, series of novel macrocyclic glycoclusters bearing mono- or dis... Read More about Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core.

Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer (2019)
Thesis
Foulkes, R. L. Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417786

Pancreatic cancer is well known for its extremely high death rate, with the current treatments purely used to extend and better the quality of the patient's life instead of providing a “cure”. Because of this, novel drug delivery methods are being lo... Read More about Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer.

Development of conjunctival and retinal models for improved eye disease treatments (2019)
Thesis
Gater, R. V. A. Development of conjunctival and retinal models for improved eye disease treatments. (Thesis). Keele University. https://keele-repository.worktribe.com/output/415221

Eye diseases such as glaucoma, macular degeneration and retinitis pigmentosa can lead to significant sight problems and blindness if left untreated. Current treatments are invasive, have a low success rate and lack the ability to regenerate damaged o... Read More about Development of conjunctival and retinal models for improved eye disease treatments.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

Assessment of fracture risk tools in care home residents (2019)
Thesis
Ihama, F. E. Assessment of fracture risk tools in care home residents. (Thesis). Keele University. https://keele-repository.worktribe.com/output/415215

Introduction
Fragility fractures are common in care home residents. National guidelines recommend risk assessment to allow initiation of prophylactic measures. Currently available risk assessment tools have been tested in community dwelling adults b... Read More about Assessment of fracture risk tools in care home residents.

Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers (2019)
Thesis
Sutton, E. R. Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417795

Cancer is a worldwide disease characterised by uncontrollable cell division and tumour growth making it a leading cause of death worldwide. The use of dietary products such a poly-unsaturated fatty acids (PUFAs) to reduce cancer growth is a current a... Read More about Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers.

The use of virtual patients for developing the evidence informed, shared decision making of clinicians (2019)
Thesis
Jacklin, S. The use of virtual patients for developing the evidence informed, shared decision making of clinicians. (Thesis). Keele University. https://keele-repository.worktribe.com/output/414956

Background
Shared decision-making (SDM) involves a patient and a health professional sharing information to arrive at a decision that aligns with both the best available evidence and the patient’s preferences. Research shows that SDM is not occurrin... Read More about The use of virtual patients for developing the evidence informed, shared decision making of clinicians.