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All Outputs (176)

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Characterising microglial activation: refinement and validation of primary in vitro models (2019)
Thesis
Al-Shaheeb, S. (2019). Characterising microglial activation: refinement and validation of primary in vitro models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413772

Background: Neuroinflammation is common to many neurodegenerative conditions and is principally mediated by microglia. Microglia maintain homeostasis, respond to trauma/infection and can promote repair. This is achieved by switching between surveilla... Read More about Characterising microglial activation: refinement and validation of primary in vitro models.

Engineering and optimising a functional in vitro model of basal ganglia circuitry (2019)
Thesis
Kӧse-Dunn, M. J. (2019). Engineering and optimising a functional in vitro model of basal ganglia circuitry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413812

The majority of neurological diseases (such as Parkinson’s and Huntington’s diseases) are progressive, debilitating and currently incurable. In an ageing population, the prevalence of such diseases will only increase over time, creating a need for be... Read More about Engineering and optimising a functional in vitro model of basal ganglia circuitry.

Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study (2019)
Thesis
Cork, T. A. (2019). Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414218

Background – Research has consistently shown that approximately 50% of patients do not take their prescribed medication correctly. A commonly overlooked factor in patient’s lack of understanding of health information and medicine instructions is limi... Read More about Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. (2019). Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).

Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models (2019)
Thesis
Muhammad Hassan, E. (2019). Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413084

Articular cartilage is a specialised tissue which covers the articulating surfaces at the end of the mammalian bone. This thin layer performs essential functions such as load bearing and shock absorption in joints. However, it lacks the ability to sa... Read More about Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models.

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis (2019)
Thesis
Moran, J. A. (2019). Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413132

The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum. Monomeric CRP (mCRP) was genera... Read More about Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis.

An investigation into the role of protein phosphatase 4 in breast cancer (2018)
Thesis
Mohammed, H. N. (2018). An investigation into the role of protein phosphatase 4 in breast cancer. (Thesis). Keele University

Breast cancer is the most common malignant tumour among females world-wide. The complexity of the pathogenesis of the disease and its heterogeneous clinical presentation, with an increasing incidence of the development of chemotherapeutic resistant c... Read More about An investigation into the role of protein phosphatase 4 in breast cancer.

Interface modification in Co/Cu multilayers prepared by ion-assisted deposition (1998)
Thesis
Telling, N. Interface modification in Co/Cu multilayers prepared by ion-assisted deposition. (Thesis). Loughborough University. Retrieved from https://keele-repository.worktribe.com/output/828742

The interfacial structure of Co/Cu multilayers deposited under energetic ion bombardment has been investigated using X-ray reflectivity techniques. An ionassisted deposition system, based on unbalanced magnetron sputtering principles, has been develo... Read More about Interface modification in Co/Cu multilayers prepared by ion-assisted deposition.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation
Thesis
Ali, I. F. (2018). Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Silicon in health: A beneficial element in reducing the body burden of aluminium
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive. T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Pharmacists in general medical practice: a case study of clinical commissioning groups
Thesis
Saunders, R. E. (2018). Pharmacists in general medical practice: a case study of clinical commissioning groups

Pharmacists have been identified to address the increasing workload in United Kingdom (UK) general practice. A pilot has been commissioned by National Health Service England (NHSE) to upskill pharmacists for this purpose. Evaluation is underway and e... Read More about Pharmacists in general medical practice: a case study of clinical commissioning groups.

Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse
Thesis
Kinikanwo Weli, H. (2018). Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse

Introduction: Pelvic organ prolapse is present in up to 50% of women. It is commoner in older women, often above 50 years of age and associated with hormonal e.g. oestrogen decline, and stiffer vaginal tissue. Pregnancy, on the contrary is a physiolo... Read More about Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. (2016). A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands

INTRODUCTION: Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes. AIM: To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. (2016). Optimising canine olfactory ensheathing cell therapy using tissue engineering tools

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

The function of sodium/calcium ion exchanger in human platelets and megakaryocytes
Thesis
(2017). The function of sodium/calcium ion exchanger in human platelets and megakaryocytes

Previously work from our lab has predicted that Ca2+ release from intracellular Ca2+ stores occurs into a Na+/Ca2+ exchanger (NCX)-associated cytosolic nanodomain enclosed within the membrane complex. In this study, we aimed to test the hypothesis th... Read More about The function of sodium/calcium ion exchanger in human platelets and megakaryocytes.

Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials
Thesis
(2018). Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials

Achieving neural regeneration after spinal cord injury (SCI) represents a significant challenge. Neural stem cell (NSC) therapy offers replacement of damaged cells and delivery of pro-regenerative factors, but >95% of cells die when transplanted to s... Read More about Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials.