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All Outputs (185)

Determinants of severity and co-morbidity in rheumatoid arthritis: influence of genetic variation and smoking
Thesis
Determinants of severity and co-morbidity in rheumatoid arthritis: influence of genetic variation and smoking. https://keele-repository.worktribe.com/output/409143

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by chronic synovial inflammation, ultimately leading to joint destruction and permanent disability. Disease expression may be affected by genetic variations and environmental fa... Read More about Determinants of severity and co-morbidity in rheumatoid arthritis: influence of genetic variation and smoking.

Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis
Thesis
Kalra, S. Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis. https://keele-repository.worktribe.com/output/409715

Multiple Sclerosis (MS) is one of the commonest disabling neurological diseases affecting the young in the developed world. It affects the central nervous system (CNS) and is characterised by inflammation with neuronal demyelination /degeneration and... Read More about Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells. https://keele-repository.worktribe.com/output/409791

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine
Thesis
Fouriki, A. Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine. https://keele-repository.worktribe.com/output/409828

Successful gene therapy depends upon specific gene delivery into the cells and tissues of interest. Nanomagnetic gene transfection is a relatively new gene delivery technique that has attempted to meet that need and has been effectively used with bot... Read More about Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine.

Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status
Thesis
Al-Zubaidi, M. A. Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status. https://keele-repository.worktribe.com/output/410000

Self-renewal and an ability to differentiate are key hallmarks of stem cells. Pluripotent stem cells (PSC) have the capacity to differentiate into all cell types found within the three germ layers; ectoderm, endoderm, mesoderm. Multipotent stem cells... Read More about Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status.

Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer
Thesis
Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer. https://keele-repository.worktribe.com/output/410307

Several long non-coding RNAs (lncRNAs) have been identified to play key, rate-limiting roles in malignancies, and the mechanisms involved are now being elucidated. This study addressed the roles of NEAT1 and MIAT lncRNAs, in breast cancer.
The short... Read More about Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer.

Electrolytic growth processes with applications to adaptive systems
Thesis
Electrolytic growth processes with applications to adaptive systems. https://keele-repository.worktribe.com/output/410413

Two types of electrolytic growth processes have been investigated as possible means of controlling impedances in adaptive systems. One of these entails the growth of conductors by metallic deposition and the other the growth of insulation by anodic o... Read More about Electrolytic growth processes with applications to adaptive systems.

An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells. https://keele-repository.worktribe.com/output/418482

Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.

Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes. https://keele-repository.worktribe.com/output/418484

Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.

The function of sodium/calcium ion exchanger in human platelets and megakaryocytes
Thesis
The function of sodium/calcium ion exchanger in human platelets and megakaryocytes. https://keele-repository.worktribe.com/output/418586

Previously work from our lab has predicted that Ca2+ release from intracellular Ca2+ stores occurs into a Na+/Ca2+ exchanger (NCX)-associated cytosolic nanodomain enclosed within the membrane complex. In this study, we aimed to test the hypothesis th... Read More about The function of sodium/calcium ion exchanger in human platelets and megakaryocytes.

Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer
Thesis
Sivakumar, R. Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer. https://keele-repository.worktribe.com/output/422989

Cyclin D1 is a key regulatory protein in the progression of G1-S phase of the cell cycle. Activated Cyclin D1 in turn activates S phase proteins and thereby leading to cell proliferation. Over expression of Cyclin D1 leads S phase cell cycle progress... Read More about Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer.

Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair
Thesis
Sharma, R. Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair. https://keele-repository.worktribe.com/output/423752

Background: An injury to the wrist and hand can impact different anatomical structures. Any damage or cut to the flexor tendons can leave a devastating impact if not treated well and can therefore compromise our daily physical activities. Surgery and... Read More about Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index. https://keele-repository.worktribe.com/output/423753

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. Optimising canine olfactory ensheathing cell therapy using tissue engineering tools. https://keele-repository.worktribe.com/output/423884

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands. https://keele-repository.worktribe.com/output/423887

INTRODUCTION:
Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes.

AIM:
To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D. https://keele-repository.worktribe.com/output/423973

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes. https://keele-repository.worktribe.com/output/423982

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
The influence of the microenvironment on vascularisation of osteochondral tissues. https://keele-repository.worktribe.com/output/423985

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.