Skip to main content

Research Repository

Advanced Search

All Outputs (39)

Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. (2012)
Journal Article
Richardson, A., Stamelos, V., & Redman, C. (2012). Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. Journal of Molecular Signaling, 12 - ?. https://doi.org/10.1186/1750-2187-7-12

BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understanding the m... Read More about Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine..

Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine (2012)
Journal Article
(2012). Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine. Journal of Nanomaterials, https://doi.org/10.1155/2012/614094

Regenerative medicine is a pioneering field aimed at restoring and regenerating the function of damaged cells, organs and tissues in order to establish normal function. It demands the cross communication of disciplines to develop effective therapeuti... Read More about Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine.

Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis (2012)
Journal Article
Akram, K. M., Lomas, N. J., Spiteri, M. A., & Forsyth, N. R. (2013). Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis. European Respiratory Journal, 41(3), 683-694. https://doi.org/10.1183/09031936.00213411

Club cells (Clara cells) participate in bronchiolar wound repair and regeneration. Located in the bronchioles, they become activated during alveolar injury in idiopathic pulmonary fibrosis (IPF) and migrate into the affected alveoli, a process called... Read More about Club cells inhibit alveolar epithelial wound repairviaTRAIL-dependent apoptosis.

Gene expression of single human mesenchymal stem cell in response to fluid shear (2012)
Journal Article
(2012). Gene expression of single human mesenchymal stem cell in response to fluid shear. Journal of Tissue Engineering, 1-8. https://doi.org/10.1177/2041731412451988

Stem cell therapy may rely on delivery and homing through the vascular system to reach the target tissue. An optical tweezer model has been employed to exert different levels of shear stress on a single non-adherent human bone marrow-derived mesenchy... Read More about Gene expression of single human mesenchymal stem cell in response to fluid shear.

Divalent metals and pH alter raltegravir disposition in vitro (2012)
Journal Article
(2012). Divalent metals and pH alter raltegravir disposition in vitro. Antimicrobial Agents and Chemotherapy, 3020-3026. https://doi.org/10.1128/AAC.06407-11

Raltegravir shows marked pharmacokinetic variability in patients, with gastrointestinal pH and divalent-metal binding being potential factors. We investigated raltegravir solubility, lipophilicity, pKa, and permeativity in vitro to elucidate known in... Read More about Divalent metals and pH alter raltegravir disposition in vitro.

The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients (2012)
Journal Article
(2012). The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients. Respiratory Medicine, https://doi.org/10.1136/bmjopen-2012-001030

Objective To improve the understanding of the determinants of prognosis and accurate risk stratification in community-acquired pneumonia (CAP). Design Multicentre collaboration of prospective cohorts. Setting 6 cohorts from the USA, Canada, Hon... Read More about The International Community Acquired Pneumonia (CAP) collaboration Cohort (ICCC) study: rationale, design and description of study cohorts and patients.

Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. (2012)
Journal Article
(2012). Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. Journal of Neurotrauma, 1614 - 1625. https://doi.org/10.1089/neu.2011.2109

Mesenchymal stem cells (MSC) derived from bone marrow can potentially reduce the acute inflammatory response in spinal cord injury (SCI) and thus promote functional recovery. However, the precise mechanisms through which transplanted MSC attenuate in... Read More about Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury..

Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD (2012)
Journal Article
COKER, V. S., BYRNE, J. M., TELLING, N. D., VAN DER LAAN, G., LLOYD, J. R., HITCHCOCK, A. P., …PATTRICK, R. A. D. (2012). Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD. Geobiology, 10(4), 347-354. https://doi.org/10.1111/j.1472-4669.2012.00329.x

A combination of scanning transmission X-ray microscopy and X-ray magnetic circular dichroism was used to spatially resolve the distribution of different carbon and iron species associated with Shewanella oneidensis MR-1 cells. S. oneidensis MR-1 cou... Read More about Characterisation of the dissimilatory reduction of Fe(III)‐oxyhydroxide at the microbe – mineral interface: the application of STXM–XMCD.

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. (2012)
Journal Article
Di Leva. (2012). Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Molecular Oncology, 458 - 472. https://doi.org/10.1016/j.molonc.2012.03.003

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA l... Read More about Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer..

Orthopaedic applications of nanoparticle-based stem cell therapies (2012)
Journal Article
(2012). Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Research and Therapy, 13 - ?. https://doi.org/10.1186/scrt104

Stem cells have tremendous applications in the field of regenerative medicine and tissue engineering. These are pioneering fields that aim to create new treatments for disease that currently have limited therapies or cures. A particularly popular ave... Read More about Orthopaedic applications of nanoparticle-based stem cell therapies.

Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study (2012)
Journal Article
(2012). Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Research and Therapy, R81 -?. https://doi.org/10.1186/ar3804

Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine that plays important roles in immunity and inflammation. Some studies have suggested that polymorphism in the TGFB1 gene is associated with heart disease in the general population... Read More about Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.

The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism (2012)
Journal Article
(2012). The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism. Journal of Nanobiotechnology, https://doi.org/10.1186/1477-3155-10-15

Background: Iron oxide magnetic nanoparticles (MNP’s) have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or ef... Read More about The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism.

Global impact of asthma on children and adolescents' daily lives: the room to breathe survey (2012)
Journal Article
(2012). Global impact of asthma on children and adolescents' daily lives: the room to breathe survey. Pediatric Pulmonology, 346-357. https://doi.org/10.1002/ppul.21557

Objective To establish children and adolescents' perspectives regarding their asthma and its impact upon their daily lives. Design A 14-item questionnaire. Setting Canada, Greece, Hungary, The Netherlands, the United Kingdom, and South Afric... Read More about Global impact of asthma on children and adolescents' daily lives: the room to breathe survey.

Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15 (2012)
Journal Article
(2012). Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Molecular Human Reproduction, 121 - 128

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for normal fertility. Both of these proteins are members of the transforming growth factor beta... Read More about Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.

Prior antiplatelet or anticoagulant therapy and mortality in stroke (2012)
Journal Article
(2012). Prior antiplatelet or anticoagulant therapy and mortality in stroke. Heart, 712 - 717. https://doi.org/10.1136/heartjnl-2011-301076

Objective To examine the influence of previous antiplatelet or anticoagulant therapy on subsequent stroke mortality at different time points up to 1 year post stroke. Design Data were examined from a hospital register collected over 5 years (2004–... Read More about Prior antiplatelet or anticoagulant therapy and mortality in stroke.

Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey (2012)
Journal Article
(2012). Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey. European Respiratory Journal, 90-96. https://doi.org/10.1183/09031936.00048911

The aim of our study was to determine how often asthma control is achieved in children and adolescents, and how asthma affects parents' and children's daily lives. Interviews, including the childhood asthma control test (C-ACT), were conducted wit... Read More about Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey.

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum (2012)
Journal Article
Horrocks. (2012). An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum. Malaria Journal, 42 -?. https://doi.org/10.1186/1475-2875-11-42

This report describes the optimization and evaluation of a simple single-step lysis protocol to measure luciferase bioluminescence from genetically modified Plasmodium falciparum. This protocol utilizes a modified commercial buffer to improve speed o... Read More about An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum.

Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis (2012)
Journal Article
(2012). Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Research and Therapy, R127 - ?. https://doi.org/10.1186/ar3857

The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. Serum levels of some cytokines and MMPs have been found to be elevated in active disea... Read More about Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis.