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Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice (2014)
Journal Article
Kehoe, O., Kalia, N., King, S., Eustace, A., Middleton, J., Boyes, C., …Patterson, A. (2014). Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice. Arthritis Research and Therapy, R148 -?. https://doi.org/10.1186/ar4610

INTRODUCTION: Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficki... Read More about Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice.

Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study (2014)
Journal Article
(2014). Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study. BMJ Open, e005429 -?. https://doi.org/10.1136/bmjopen-2014-005429

OBJECTIVES: The study investigated (1) the association between comorbidity and multidrug prescribing compared with the index condition, and (2) the association between vascular comorbidity and non-vascular condition key drug prescribing. DESIGN: Cros... Read More about Chronic condition comorbidity and multidrug therapy in general practice populations: a cross-sectional linkage study.

Using Fourier transform IR spectroscopy to analyze biological materials (2014)
Journal Article
Baker, M. J., Trevisan, J., Bassan, P., Bhargava, R., Butler, H. J., Dorling, K. M., …Martin, F. L. (2014). Using Fourier transform IR spectroscopy to analyze biological materials. Nature Protocols, 9(8), 1771-1791. https://doi.org/10.1038/nprot.2014.110

IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative, label-free extraction of biochemical information and images toward diagnosis and the assessment of cell functionality. Although not strictly microscopy in... Read More about Using Fourier transform IR spectroscopy to analyze biological materials.

Mouse GDF9 decreases KITL gene expression in human granulosa cells (2014)
Journal Article
Tuck, A. R., Mottershead, D. G., Fernandes, H. A., Norman, R. J., Tilley, W. D., Robker, R. L., & Hickey, T. E. (2015). Mouse GDF9 decreases KITL gene expression in human granulosa cells. Endocrine, 48(2), 686-695. https://doi.org/10.1007/s12020-014-0335-6

Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothes... Read More about Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients (2014)
Journal Article
(2014). Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients. Critical Care, R137 - ?. https://doi.org/10.1186/cc13958

INTRODUCTION: Neutrophil gelatinase-associated lipocalin (NGAL) has been demonstrated to be a useful early diagnostic biomarker of acute kidney injury (AKI) where the timing of the insult is certain. However, NGAL is not well validated in adult criti... Read More about Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients.

Real-time simulation of three-dimensional shoulder girdle and arm dynamics (2014)
Journal Article
(2014). Real-time simulation of three-dimensional shoulder girdle and arm dynamics. IEEE Transactions on Biomedical Engineering, 1947 - 1956. https://doi.org/10.1109/TBME.2014.2309727

Electrical stimulation is a promising technology for the restoration of arm function in paralyzed individuals. Control of the paralyzed arm under electrical stimulation, however, is a challenging problem that requires advanced controllers and command... Read More about Real-time simulation of three-dimensional shoulder girdle and arm dynamics.

Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation (2014)
Journal Article
Romano, G., Acunzo, M., Garofalo, M., Di Leva, G., Cascione, L., Zanca, C., …Croce, C. M. (2014). Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation. Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10389-10389. https://doi.org/10.1073/pnas.1410423111

CELL BIOLOGY Correction for “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation,” by Giulia Romano, Mario Acunzo, Michela Garofalo, Gianpiero Di Leva, Luciano Cascione, Ciro... Read More about Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation.

Clinicalcodes: an online clinical codes repository to improve the validity and reproducibility of research using electronic medical records (2014)
Journal Article
(2014). Clinicalcodes: an online clinical codes repository to improve the validity and reproducibility of research using electronic medical records. PloS one, e99825 - e99825. https://doi.org/10.1371/journal.pone.0099825

Lists of clinical codes are the foundation for research undertaken using electronic medical records (EMRs). If clinical code lists are not available, reviewers are unable to determine the validity of research, full study replication is impossible, re... Read More about Clinicalcodes: an online clinical codes repository to improve the validity and reproducibility of research using electronic medical records.

Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. (2014)
Journal Article
Ives, N., Sim, J., Gray, R., Roffe, C., Nevatte, T., & Howman, A. (2014). Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. Trials, 15, Article ARTN 229. https://doi.org/10.1186/1745-6215-15-229

BACKGROUND: The Stroke Oxygen Study (SO2S) is a multi-center randomized controlled trial of oxygen supplementation in patients with acute stroke. The main hypothesis for the trial is that fixed-dose oxygen treatment during the first 3 days after an a... Read More about Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome..

The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods (2014)
Journal Article
(2014). The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods. International Journal of Mass Spectrometry, 467 - 478. https://doi.org/10.1016/j.ijms.2014.05.016

Flow tube reactors coupled with quantitative mass spectrometry have made, and continue to make, major contributions to gas phase ion–molecule chemistry, to recombination and electron attachment studies and, most recently, to gas phase trace gas analy... Read More about The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods.

MicroRNA Profiles Discriminate among Colon Cancer Metastasis (2014)
Journal Article
Drusco, A., Nuovo, G. J., Zanesi, N., Di Leva, G., Pichiorri, F., Volinia, S., …Croce, C. M. (in press). MicroRNA Profiles Discriminate among Colon Cancer Metastasis. PloS one, 9(6), Article e96670. https://doi.org/10.1371/journal.pone.0096670

MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predic... Read More about MicroRNA Profiles Discriminate among Colon Cancer Metastasis.

The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: Implications for pre-clinical studies and clinical trials for spinal muscular atrophy (2014)
Journal Article
Hunter, G., Roche, S. L., Somers, E., Fuller, H. R., & Gillingwater, T. H. (2014). The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: Implications for pre-clinical studies and clinical trials for spinal muscular atrophy. Neuromuscular Disorders, 24(11), 973-977. https://doi.org/10.1016/j.nmd.2014.05.013

Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner (2014)
Presentation / Conference
Dale, T. P., De Castro, A., Parkinson, E. K., Kuiper, N. J., & Forsyth, N. R. (2014, June). Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner. Poster presented at Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting, Magazzini del Cotone Congress Center, Genova, Italy

Introduction: Limited therapeutic options for the treatment of cartilage damage have driven the development of cell therapy alternatives. How-ever, many of the relevant cell types are difficult to study due to the rapid onset of replicative senescenc... Read More about Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner.

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide ß-amyloid (1-42). (2014)
Journal Article
Everett, & Telling. (2014). Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide ß-amyloid (1-42). https://doi.org/10.1098/rsif.2014.0165

For decades, a link between increased levels of iron and areas of Alzheimer's disease (AD) pathology has been recognized, including AD lesions comprised of the peptide ß-amyloid (Aß). Despite many observations of this association, the relationship be... Read More about Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide ß-amyloid (1-42)..

Similarity of patient characteristics and outcomes in consecutive data collection on stroke admissions over one month compared to longer periods (2014)
Journal Article
(2014). Similarity of patient characteristics and outcomes in consecutive data collection on stroke admissions over one month compared to longer periods. BMC Research Notes, 342. https://doi.org/10.1186/1756-0500-7-342

Background The usefulness of time-limited consecutive data collection compared to continuous consecutive data collection in conditions which show seasonal variations is unclear. The objective of this study is to assess whether one month of admission... Read More about Similarity of patient characteristics and outcomes in consecutive data collection on stroke admissions over one month compared to longer periods.

Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil (2014)
Journal Article
Johnson-Ajinwo, O. R., & Li, W. (2014). Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil. Journal of Agricultural and Food Chemistry, 62(24), 5466-5471. https://doi.org/10.1021/jf500357x

Black cumin seed (Nigella sativa L.) is a widely used spice and herb, where thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) is the major bioactive compound. Here, a stable isotope dilution (SID) gas chromatography–mass spectrometry (GC–MS) techn... Read More about Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil.

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis (2014)
Journal Article
Kehoe, O., Cartwright, A., Askari, A., El Haj, A., & Middleton, J. (2014). Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. Journal of Translational Medicine, 157 - ?. https://doi.org/10.1186/1479-5876-12-157

BACKGROUND: Rheumatoid arthritis (RA) is a debilitating and painful disease leading to increased morbidity and mortality and novel therapeutic approaches are needed. The purpose of this study was to elucidate if mesenchymal stem cells (MSCs) injected... Read More about Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis.