All Outputs (243)

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Preparation of Alkyl Alkynyl Sulfones and Cyclic Vinyl Sulfones from Alkynyl(aryl)iodonium Salts (2016)
Journal Article
Rodríguez, A., & Moran, W. J. (2016). Preparation of Alkyl Alkynyl Sulfones and Cyclic Vinyl Sulfones from Alkynyl(aryl)iodonium Salts. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.6b00124

Interprofessional education (IPE) in education and training programmes approved by the Health Care Professions Council (HCPC); a Report (2016)
Report
Shardlow, S., Bucher, C., Maddock, K., Meredith, R., Morris, A., & Pooler, A. (2016). Interprofessional education (IPE) in education and training programmes approved by the Health Care Professions Council (HCPC); a Report. TBC

Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis. Drug Safety, 229-240. https://doi.org/10.1007/s40264-016-0481-2

Introduction Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We... Read More about Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis.

004 Long Term Therapy With Testosterone Undecanoate in Type 2 Diabetes was Associated With Reduced All-Cause Mortality but no Significant Improvement in Conventional Risk Factors for CVD (2016)
Journal Article
(2016). 004 Long Term Therapy With Testosterone Undecanoate in Type 2 Diabetes was Associated With Reduced All-Cause Mortality but no Significant Improvement in Conventional Risk Factors for CVD. Journal of Sexual Medicine, S2 - S3. https://doi.org/10.1016/j.jsxm.2016.11.008

No abstract

A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials (2016)
Journal Article
Horrocks. (2016). A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials. Journal of Antimicrobial Chemotherapy, 717-726. https://doi.org/10.1093/jac/dkw449

Objectives: A future treatment for uncomplicated malaria will contain at least one component that exerts a rapid rate of kill. We describe here the validation and application of a simple, robust and rapid bioluminescence-based assay for the determina... Read More about A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.

The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood (2016)
Journal Article
Hulme, C., Brown, S., Fuller, H., Riddell, J., Osman, A., Chowdhury, J., …Wright, K. (2017). The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood. Spinal Cord, 55, 114-125. https://doi.org/10.1038/sc.2016.174

Objectives: The identification of prognostic biomarkers of spinal cord injury (SCI) will help to assign SCI patients to the correct treatment and rehabilitation regimes. Further, the detection of biomarkers that predict permanent neurological outcom... Read More about The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood.

Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology (2016)
Journal Article
Davoodi, P., Ghoreishi, S. M., & Hedayati, A. (2017). Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology. Korean Journal of Chemical Engineering, 34(3), 854-865. https://doi.org/10.1007/s11814-016-0304-2

Supercritical CO2 extraction of galegine from Galega officinalis L. was carried out under different operating conditions of temperature (35-55 °C), pressure (10-30MPa), dynamic extraction time (30-150min), CO2 flow rate (0.5-2.5 mL/min) and constant... Read More about Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology.

Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies (2016)
Journal Article
Owen, S., Jones, P., Caterson, B., Shirran, S., Fuller, H., Botting, C., & Roberts, S. (2016). Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies. Bioscience Reports, https://doi.org/10.1042/BSR20160465

This paper reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and are expected to have been rigorously assessed for their p... Read More about Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., …Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions (2016)
Journal Article
Aires, A., Cabrera, D., Alonso-Pardo, L. C., Cortajarena, A. L., & Teran, F. J. (2017). Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions. ChemNanoMat, 3(3), 183-189. https://doi.org/10.1002/cnma.201600333

Nanotechnology has brought countless novel applications regarding therapeutic, diagnostic, and sensing innovations. In particular, nanoparticle engineering enables the synthesis of nanocrystals with customized physical, chemical, and biological activ... Read More about Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions.

Biological challenges for regeneration of the degenerated disc using cellular therapies (2016)
Journal Article
(2016). Biological challenges for regeneration of the degenerated disc using cellular therapies. Acta orthopaedica, 39 -46. https://doi.org/10.1080/17453674.2017.1297916

In this review, we discuss some of the challenges in successful cellular repair of the disc. We fi rst review the function, organization, and composition of a normal disc, outline the changes that occur in degeneration, and consider how these might i... Read More about Biological challenges for regeneration of the degenerated disc using cellular therapies.

Acceptability and potential effectiveness of commercial portion control tools amongst people with obesity (2016)
Journal Article
Solis-Trapala. (2016). Acceptability and potential effectiveness of commercial portion control tools amongst people with obesity. British Journal of Nutrition, 1974 -1983. https://doi.org/10.1017/S0007114516004104

Exposure to large portion sizes is a risk factor for obesity. Specifically designed tableware may modulate how much is eaten and help with portion control. We examined the experience of using a guided crockery set (CS) and a calibrated serving spoon... Read More about Acceptability and potential effectiveness of commercial portion control tools amongst people with obesity.

Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp (2016)
Journal Article
Aldulaimi, O., & Li, W. (2016). Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp. Planta Medica, s1-s381. https://doi.org/10.1055/s-0036-1596585

Flower buds of Magnolia biondii Pamp (family Magnoliaceae) is known as Xin-Yi in the Chinese Pharmacopoeia, and is widely used for the treatment of allergic rhinitis, rhinosinusitis, nasal congestion, and headache.1 Bacterial infection caused by Stap... Read More about Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp.

Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study. (2016)
Journal Article
(2016). Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study. BMJ Open, e013837 - ?. https://doi.org/10.1136/bmjopen-2016-013837

OBJECTIVES: To identify the authentication and detection rate of serialised medicines using medicines authentication technology. DESIGN AND INTERVENTION: 4192 serialised medicines were entered into a hospital dispensary over two separate 8-week stage... Read More about Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study..

Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer (2016)
Journal Article
Robinson, E., Abdullah, M., Jones, S., Menezes, K., Euan, S., Hoskins, C., & Richardson, A. (2016). Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer. European Journal of Cancer, 69(S1), S150. https://doi.org/10.1016/s0959-8049%2816%2933045-3

Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel (2016)
Journal Article
Abed, M., & Richardson, A. (2016). Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel. European Journal of Cancer, 69(S1), S20. https://doi.org/10.1016/s0959-8049%2816%2932640-5

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning (2016)
Journal Article
Siddique, M., Rutter, A., Wehbe, K., Cinque, G., Bellisola, G., & Sule-Suso, J. (2016). Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning. Analyst, 8(142), 1299-1307. https://doi.org/10.1039/c6an01914e

Over the last few years, both synchrotron-based FTIR (S-FTIR) and Raman microspectroscopies have helped to better understand the effects of drugs on cancer cells. However, cancer is a mixture of cells with different sensitivity/resistance to drugs. F... Read More about Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning.

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines (2016)
Journal Article
van Rensburg, M., Leung, E., Haverkate, N. A., Eurtivong, C., Pilkington, L. I., Reynisson, J., & Barker, D. (2017). Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines. Bioorganic and Medicinal Chemistry Letters, 27(2), 135-138. https://doi.org/10.1016/j.bmcl.2016.12.009

3-Amino-2-arylcarboxamide-thieno[2,3-b]pyridines are a known class of antiproliferative compounds with activity against the phospholipase C enzyme. To further investigate the structure activity relationships of these derivatives a series of analogues... Read More about Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines.

Modeling Nutritional Outcomes for Infants Diagnosed With Cystic Fibrosis by Newborn Screening (Meeting Abstract) (2016)
Journal Article
Patterson, K., Kyriacou, T., Desai, M., Carroll, W., & Gilchrist, F. (2016). Modeling Nutritional Outcomes for Infants Diagnosed With Cystic Fibrosis by Newborn Screening (Meeting Abstract). Thorax, 71(3), A131 -A132. https://doi.org/10.1136/thoraxjnl-2016-209333.232

Meeting abstract published in supplement of the Thorax journal, December 2016.