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Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides (2016)
Journal Article
Anderson, R. F., Yadav, P., Shinde, S. S., Hong, C. R., Pullen, S. M., Reynisson, J., …Hay, M. P. (2016). Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides. Chemical Research in Toxicology, 29(8), 1310-1324. https://doi.org/10.1021/acs.chemrestox.6b00133

The radical chemistry and cytotoxicity of a series of quinoxaline di-N-oxide (QDO) compounds has been investigated to explore the mechanism of action of this class of bioreductive drugs. A series of water-soluble 3-trifluoromethyl (4–10), 3-phenyl (1... Read More about Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.

Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force (2016)
Journal Article
Roffe. (2016). Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force. European Respiratory Journal, 992-1018. https://doi.org/10.1183/13993003.01975-2015

Sleep disordered breathing (SDB) is a leading cause of morbidity worldwide. Its prevalence increases with age. Due to the demographic changes in industrial societies, pulmonologists and sleep physicians are confronted with a rapidly growing number of... Read More about Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force.

Ultrasound induced fluorescence of nanoscale liposome contrast agents (2016)
Journal Article
(2016). Ultrasound induced fluorescence of nanoscale liposome contrast agents. PloS one, https://doi.org/10.1371/journal.pone.0159742

A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was de... Read More about Ultrasound induced fluorescence of nanoscale liposome contrast agents.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016)
Journal Article
Horrocks. (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, https://doi.org/10.1371/journal.ppat.1005763

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More about Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs) (2016)
Journal Article
Liddell, S., Fuller, H., Stanley, R., Schramm, G., Igetei, J., Doenhoff, M., & El-Faham, M. (2016). Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs). PloS one, https://doi.org/10.1371/journal.pone.0159542

IgG antibodies produced by rabbits immunized against S. mansoni antigens cross-reacted with aqueous soluble constituents of a variety of allergens. The antibody cross-reactivity was largely sensitive to degradation by treatment of the target antigens... Read More about Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs).

Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow (2016)
Journal Article
Mennan, C., Brown, S., McCarthy, H., Mavrogonatou, E., Kletsas, D., Garcia, J., …Roberts, S. (2016). Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow. FEBS Open Bio, 6(11), 1054-1066. https://doi.org/10.1002/2211-5463.12104

Mesenchymal stromal cells (MSC) can be isolated from several regions of human umbilical cords, including Wharton's jelly (WJ), artery, vein or cord lining. These MSC appear to be immune privileged and are promising candidates for cell therapy. Howeve... Read More about Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow.

Title: Melatonin, hypnotics and their association with fracture: a matched cohort study (2016)
Journal Article
Frisher, M., Gibbons, N., Bashford, J., Chapman, S., & Weich, S. (2016). Title: Melatonin, hypnotics and their association with fracture: a matched cohort study. Age and ageing, 45(6), 801-806. https://doi.org/10.1093/ageing/afw123

Objectives although melatonin prescribing in England has been increasing in recent years, there have been no large scale studies on the safety of melatonin compared to other medical treatments for insomnia. The primary aim of this study was to exami... Read More about Title: Melatonin, hypnotics and their association with fracture: a matched cohort study.

Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis. International Journal of Clinical Practice, 791-805. https://doi.org/10.1111/ijcp.12841

Background Soft drink consumption is associated with adverse health behaviours that predispose to adverse cardiovascular risk factor profiles; however, it is unclear whether their intake independently leads to an increased risk of cardiovascular eve... Read More about Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis.

Stem Cell Delivery with Polymer Hydrogel for Treatment of Intervertebral Disc Degeneration: From 3D Culture to Design of the Delivery Device for Minimally Invasive Therapy. (2016)
Journal Article
(2016). Stem Cell Delivery with Polymer Hydrogel for Treatment of Intervertebral Disc Degeneration: From 3D Culture to Design of the Delivery Device for Minimally Invasive Therapy. Cell Transplantation, 2213-2220. https://doi.org/10.3727/096368916X692618

Nucleus pulposus (NP) tissue damage can induce detrimental mechanical strain on the biomechanical performance of intervertebral disc (IVD) causing subsequent disc degeneration. A novel, photocurable, injectable, synthetic polymer hydrogel (pHEMA-co-A... Read More about Stem Cell Delivery with Polymer Hydrogel for Treatment of Intervertebral Disc Degeneration: From 3D Culture to Design of the Delivery Device for Minimally Invasive Therapy..

Immobilized WNT Proteins Act as Stem Cell Niche for Tissue Engineering (2016)
Journal Article
(2016). Immobilized WNT Proteins Act as Stem Cell Niche for Tissue Engineering. Stem Cell Reports, 126 - 137. https://doi.org/10.1016/j.stemcr.2016.06.004

The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult tissues. Consequently the ability to provide a defined and directed source of WNT proteins is crucial to fully underst... Read More about Immobilized WNT Proteins Act as Stem Cell Niche for Tissue Engineering.

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. (2016)
Journal Article
Yang, Y. (2016). Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. Regenerative Medicine, 483 - 492. https://doi.org/10.2217/rme-2016-0053

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to de... Read More about Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015..

Is regular drinking in later life an indicator of good health? Evidence from the English Longitudinal Study of Ageing (2016)
Journal Article
Holdsworth, C., Mendonça, M., Pikhart, H., Frisher, M., de Oliveira, C., & Shelton, N. (2016). Is regular drinking in later life an indicator of good health? Evidence from the English Longitudinal Study of Ageing. Journal of epidemiology and community health, 70(8), 764-770. https://doi.org/10.1136/jech-2015-206949

Background Older people who drink have been shown to have better health than those who do not. This might suggest that moderate drinking is beneficial for health, or, as considered here, that older people modify their drinking as their health deterio... Read More about Is regular drinking in later life an indicator of good health? Evidence from the English Longitudinal Study of Ageing.

A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. (2016)
Journal Article
Yang, Y., Musa, F., & Harper, A. (2016). A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. Tissue Engineering Part C: Methods, 691 - 699. https://doi.org/10.1089/ten.tec.2015.0582

Native blood vessels contain both an antiaggregatory intimal layer, which prevents platelet activation in the intact vessel, and a proaggregatory medial layer, which stimulates platelet aggregation upon vascular damage. Yet, current techniques for as... Read More about A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall..

Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation (2016)
Journal Article
Fuller, H., Graham, L., Llavero Hurtado, M., & Wishart, T. (2016). Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation. Expert Review of Proteomics, 659-671. https://doi.org/10.1080/14789450.2016.1202768

Introduction: Proteomic techniques offer insights into the molecular perturbations occurring in muscular-dystrophies (MD). Revisiting published datasets can highlight conserved downstream molecular alterations, which may be worth re-assessing to dete... Read More about Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation.

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes (2016)
Journal Article
Wieczorek, A., Błauż, A., Żal, A., Arabshahi, H. J., Reynisson, J., Hartinger, C. G., …Plażuk, D. (2016). Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes. Chemistry - A European Journal, 22(32), 11413-11421. https://doi.org/10.1002/chem.201601809

A series of ferrocenyl analogues and derivatives of paclitaxel and docetaxel were synthesised and assayed for their antiproliferative/cytotoxic effects, impact on the cell cycle distribution and ability to induce tubulin polymerisation. The replaceme... Read More about Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.