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Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 (2019)
Journal Article
Reynisson. (2019). Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. Nature communications, 4639 - ?. https://doi.org/10.1038/s41467-019-12614-7

Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the lipid metabolites acetyl-CoA or propionyl-CoA to ICL2 induces a striking structural rearra... Read More about Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.

Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies (2019)
Journal Article
Telling, & Everett, J. (2019). Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells, https://doi.org/10.3390/cells8101231

Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spe... Read More about Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.

Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. (2019)
Journal Article
Mamas. (2019). Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. BMJ, l5476 -?. https://doi.org/10.1136/bmj.l5476

OBJECTIVE: To assess the effects of different oral antithrombotic drugs that prevent saphenous vein graft failure in patients undergoing coronary artery bypass graft surgery. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medli... Read More about Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis..

Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation (2019)
Presentation / Conference
Hulme, C., Roberts, S., Gallacher, P., Jermin, P., Richardson, J., & Wright, K. (2019, October). Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation. Paper presented at International Joint and Cartilage Preservation Society (ICRS) 2019, Vancouver, Canada

Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon. (2019)
Journal Article
(2019). Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon. Clinical Anatomy, https://doi.org/10.1002/ca.23490

INTRODUCTION: The fibrocartilagenous plantar plates of the forefoot are biomechanically important, forming the primary distal attachment for the plantar aponeurosis. They are integral to the function of the windlass mechanism in supporting the arches... Read More about Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon..

Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential (2019)
Journal Article
Mennan, C., Garcia, J., McCarthy, H., Owen, S., Perry, J., Wright, K., …Roberts, S. (2019). Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential. Cartilage, 10(4), 467-479. https://doi.org/10.1177/1947603518769714

Objective To assess the phenotype of human articular chondrocytes cultured in normoxia (21% O2) or continuous hypoxia (2% O2). Design Chondrocytes were extracted from patients undergoing total knee replacement (n = 5) and cultured in ~21% (normo... Read More about Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential.

Prediction of pathological fracture in patients with metastatic disease of the lower limb (2019)
Journal Article
Cool. (in press). Prediction of pathological fracture in patients with metastatic disease of the lower limb. Scientific reports, 9, Article 14133. https://doi.org/10.1038/s41598-019-50636-9

The aim of this study was to investigate if the risk of pathological fracture can be predicted with the proportion of body weight that can be put through the affected leg in patients with metastatic bone disease of the lower limb. A prospective obser... Read More about Prediction of pathological fracture in patients with metastatic disease of the lower limb.

The effect of high glucose on lipid metabolism in the human placenta (2019)
Journal Article
Hulme. (2019). The effect of high glucose on lipid metabolism in the human placenta. Scientific reports, https://doi.org/10.1038/s41598-019-50626-x

Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose co... Read More about The effect of high glucose on lipid metabolism in the human placenta.

Virtual patient educational intervention for the development of shared decision-making skills: a pilot study. (2019)
Journal Article
Jacklin, S., Chapman, S., & Maskrey, N. (2019). Virtual patient educational intervention for the development of shared decision-making skills: a pilot study. BMJ Simulation and Technology Enhanced Learning, 215 - 217

Background: Shared decision-making (SDM) involves a healthcare professional and a patient forming a congruent partnership, within which information is shared and decisions are made which align with the patient's values. SDM does not occur to the exte... Read More about Virtual patient educational intervention for the development of shared decision-making skills: a pilot study..

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. (2019)
Journal Article
Wragg. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 6156 - 6167. https://doi.org/10.1007/s12035-019-1500-y

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a... Read More about Systematic Review of miRNA as Biomarkers in Alzheimer's Disease..

Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems (2019)
Journal Article
Li, B., Zhou, D., Ogrodnik, P., & Xu, W. (2020). Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 234(7), 1092-1105. https://doi.org/10.1177/1350650119876221

The present study investigates the effect of cylindricity error on the performance of hydrodynamic journal bearing systems. Two types of cylindricity errors of the journal, namely the drum shape distribution cylindricity error (DCE) and the saddle sh... Read More about Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA. The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity. More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial (2019)
Journal Article
(2019). Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. The Lancet, https://doi.org/10.1016/S0140-6736%2819%2932039-2

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronar... Read More about Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. (2019)
Journal Article
Heald, A., Davies, M., Stedman, M., Livingston, M., Lunt, M., Fryer, A., & Gadsby, R. (2019). Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. BMJ Open, 9(9), e028278 - ?. https://doi.org/10.1136/bmjopen-2018-028278

OBJECTIVE: Evaluate relative clinical effectiveness of treatment options for type 2 diabetes mellitus (T2DM) using a statistical model of real-world evidence within UK general practitioner practices (GPP), to quantify the opportunities for diabetes c... Read More about Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes..

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle (2019)
Journal Article
Holt, I., Fuller, H., Lam, L., Sewry, C., Shirran, S., Zhang, Q., …Morris, G. (2019). Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. Scientific reports, https://doi.org/10.1038/s41598-019-50728-6

Nesprins, nuclear envelope spectrin-repeat proteins encoded by the SYNE1 and SYNE2 genes, are involved in localization of nuclei. The short isoform, nesprin-1-alpha2, is required for relocation of the microtubule organizer function from centromeres t... Read More about Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter? (2019)
Journal Article
Mamas. (2019). Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?. European Journal of Preventive Cardiology, 2047487319871709 - 2047487319871709. https://doi.org/10.1177/2047487319871709

Background Whilst antithrombotic therapy is recommended in people with atrial fibrillation, little is known about the survival benefits of antithrombotic treatment in those with both high ischaemic and bleeding risk scores. We aim to describe the dis... Read More about Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?.

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes (2019)
Journal Article
(2019). Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes. Advances in therapy, 2547 - 2557. https://doi.org/10.1007/s12325-019-01066-6

Inhalable medications for patients with asthma and chronic obstructive pulmonary disease (COPD) can be confusing even for health care professionals because of the multitude of available devices each with different operating principles. Dry powder inh... Read More about Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes.

Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry (2019)
Journal Article
Roffe. (2019). Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry. Diabetes, db190440 - db190440. https://doi.org/10.2337/db19-0440

Available data from observational studies on the association of admission hyperglycaemia (aHG) with outcomes of acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) are contradictory especially when stratified by diabetes... Read More about Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry.

Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. International Journal of Cardiology, 7-14. https://doi.org/10.1016/j.ijcard.2019.05.035

Acute coronary syndromes (ACS) are an important cause of morbidity and mortality worldwide. Current guidelines recommend early management with potent antiplatelet agents and an early invasive coronary intervention strategy for both non-ST elevation m... Read More about Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome..