All Outputs (135)

Bringing ethical dilemmas to life; the use of drama teaching in healthcare education (2021)
Journal Article
Jacklin, S., & Allinson, M. (2021). Bringing ethical dilemmas to life; the use of drama teaching in healthcare education. The Journal of Academic Development and Education, https://doi.org/10.21252/29rw-zt56

Context and objectives Empathy is an important element that underpins a health professional’s ability to handle ethical dilemmas involving patients, with a focus on providing person-centred care. The aim of this project was to evaluate the use of an... Read More about Bringing ethical dilemmas to life; the use of drama teaching in healthcare education.

Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT (2021)
Journal Article
Adab, P., Jordan, R. E., Fitzmaurice, D., Ayres, J. G., Cheng, K., Cooper, B. G., …Turner, A. (2021). Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT. Programme Grants for Applied Research, 9(13), 1 - 148. https://doi.org/10.3310/pgfar09130

BackgroundChronic obstructive pulmonary disease is a major contributor to morbidity, mortality and health service costs but is vastly underdiagnosed. Evidence on screening and how best to approach this is not clear. There are also uncertainties aroun... Read More about Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT.

Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells (2021)
Thesis
Fadayomi, I. E. (2021). Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells. (Thesis). Keele University

Ovarian cancer is a gynaecological malignancy associated with the highest level of death. Its resistance against anti-cancer drugs in recent time has exacerbated the problem. Hence, the search for novel drugs from plants used in traditional medicine... Read More about Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells.

Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study (2021)
Thesis
Chatzixenitidis, A. (2021). Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study. (Thesis). Keele University

Background and aim: Information support is an integral part of cancer care, but its provision can be problematic in busy health settings. The aim of this project was to develop and evaluate a health app to facilitate the provision of information supp... Read More about Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study.

Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance (2021)
Journal Article
Pearson. (2021). Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, 6581 - 6581. https://doi.org/10.3390/molecules26216581

Glyceryl trinitrate (GTN) is one of the earliest known treatments for angina with a fascinating history that bridges three centuries. However, despite its central role in the nitric oxide (NO) story as a NO-donating compound, establishing the precise... Read More about Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.

Physoxia alters human mesenchymal stem cell secretome (2021)
Journal Article
(2021). Physoxia alters human mesenchymal stem cell secretome. Journal of Tissue Engineering, https://doi.org/10.1177/20417314211056132

The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppres... Read More about Physoxia alters human mesenchymal stem cell secretome.

Predictors of postoperative hospital length of stay after total knee arthroplasty. (2021)
Journal Article
(2021). Predictors of postoperative hospital length of stay after total knee arthroplasty. https://doi.org/10.11622/smedj.2021142

INTRODUCTION: To collect and analyse clinical and functional variables of patients undergoing rehabilitation after total knee arthroplasty (TKA), in order to identify which amongst them could influence the post-operative length of hospital stay (LOS)... Read More about Predictors of postoperative hospital length of stay after total knee arthroplasty..

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. (2021)
Journal Article
(2021). Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. Cells, https://doi.org/10.3390/cells10112819

BACKGROUND: Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cel... Read More about Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation..

Fragility Fractures: Risk Factors and Management in the Elderly. (2021)
Journal Article
(2021). Fragility Fractures: Risk Factors and Management in the Elderly. https://doi.org/10.3390/medicina57101119

Given the progressive ageing of Western populations, the fragility fractures market has a growing socioeconomic impact. Fragility fractures are common in the elderly, negatively impacting their quality of life, limiting autonomy, increasing disabilit... Read More about Fragility Fractures: Risk Factors and Management in the Elderly..

Outpatient Total Knee Arthroplasty: A Meta-Analysis (2021)
Journal Article
(2021). Outpatient Total Knee Arthroplasty: A Meta-Analysis. Applied Sciences, 9376 - 9376. https://doi.org/10.3390/app11209376

Introduction: Outpatient total knee arthroplasty (TKA) is attracting growing interest. This meta-analysis compared patient reported outcome measures (PROMs), infection, readmission, revision, deep vein thrombosis (DVT), and mortality rates of outpati... Read More about Outpatient Total Knee Arthroplasty: A Meta-Analysis.

Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury (2021)
Journal Article
Chen. (2021). Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury. Spinal Cord, 1216 - 1218. https://doi.org/10.1038/s41393-021-00711-8

AbstractDegenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often late, when patien... Read More about Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury.

Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases (2021)
Journal Article
Paraskevaidi, M., Baker, M., Butler, H., Byrne, H., Chakkumpulakkal, T., Loren, C., …Wood, B. (2021). Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, https://doi.org/10.1080/05704928.2021.1946076

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the... Read More about Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases.

Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature (2021)
Journal Article
Migliorini, F., La Padula, G., Torsiello, E., Spiezia, F., Oliva, F., & Maffulli, N. (2021). Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature. European Journal of Medical Research, 26(1), Article ARTN 118. https://doi.org/10.1186/s40001-021-00593-9

Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or i... Read More about Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature.

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A., & Wright, K. T. (2022). Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 60(4), 320-325. https://doi.org/10.1038/s41393-021-00692-8

STUDY DESIGN: Explanatory and Mechanistic Study OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Dystrophin involvement in peripheral circadian SRF signalling (2021)
Journal Article
Bowerman. (2021). Dystrophin involvement in peripheral circadian SRF signalling. https://doi.org/10.26508/lsa.202101014

Absence of dystrophin, an essential sarcolemmal protein required for muscle contraction, leads to the devastating muscle-wasting disease Duchenne muscular dystrophy. Dystrophin has an actin-binding domain, which binds and stabilises filamentous-(F)-a... Read More about Dystrophin involvement in peripheral circadian SRF signalling.

Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells (2021)
Journal Article
Fadayomi, I. E., Johnson-Ajinwo, O. R., Pires, E., McCullagh, J., Claridge, T. D., Forsyth, N. R., & Li, W. (2021). Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells. Molecules, 26(19), 5933 - 5933. https://doi.org/10.3390/molecules26195933

Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson... Read More about Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture. (2021)
Journal Article
(2021). Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture. Foot and Ankle International, 10711007211038594 - ?. https://doi.org/10.1177/10711007211038594

BACKGROUND: Following percutaneous repair of acute Achilles tendon (AT) ruptures, early postoperative weightbearing is advocated; however, it is debatable how aggressive rehabilitation should be. We compared the clinical and functional outcomes in 2... Read More about Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture..

Experiencing a virtual patient to practice patient counselling skills (2021)
Journal Article
Lucy Richardson, C., Chapman, S., & White, S. (2021). Experiencing a virtual patient to practice patient counselling skills. Currents in Pharmacy Teaching and Learning, 13(12), 1593-1601. https://doi.org/10.1016/j.cptl.2021.09.048

Introduction Virtual patients (VPs) are a safe and standardised method of simulating clinical environments but few studies have explored health care professional's experiences of learning via a VP. This study explored how users experienced and used a... Read More about Experiencing a virtual patient to practice patient counselling skills.

Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells. (2021)
Journal Article
(2021). Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells. Stem Cell Research and Therapy, https://doi.org/10.1186/s13287-021-02415-5

BACKGROUND: Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal oogenesis as they have the ability to generate immature oocytes and resist the chemotherapy. These cell... Read More about Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells..

Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study (2021)
Journal Article
McClelland, D., Blackwell, J. R., O’Beirne, S., Grocott, N. E., & Ogrodnik, P. (2022). Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study. Journal of Shoulder and Elbow Surgery, 31(2), 413-419. https://doi.org/10.1016/j.jse.2021.08.018

Hypothesis: To determine the angle of osteotomy that produces a circular humeral cut surface. Methods: 49 cadaveric shoulders, from 25 cadavers, underwent sequential humeral head osteotomy from 180 degrees (vertical, in line with the humeral diaphys... Read More about Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study.