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Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo (2021)
Journal Article
Turner, D. C., Gorski, P. P., Seaborne, R. A., Viggars, M., Murphy, M., Jarvis, J. C., …Sharples, A. P. (2021). Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo. Journal of Cellular Physiology, 236(9), 6534-6547. https://doi.org/10.1002/jcp.30328

Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of bioengineered SkM in vitro adequate... Read More about Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo.

Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates (2021)
Journal Article
Das, M., Rodríguez, A., Lo, P. K. T., & Moran, W. J. (2021). Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates. Advanced synthesis & catalysis, 363(6), 1646-1650. https://doi.org/10.1002/adsc.202001451

The preparation of oxazolidinones by the hypervalent iodine mediated cyclization of allylcarbamates is described. A versatile range of substrates can be converted into substituted oxazolidinones primed for further transformations. Derivatization of t... Read More about Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates.

The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK (2021)
Journal Article
Sanyal, R., Raseta, M., Natarajan, I., & Roffe, C. (2022). The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK. International Journal of Stroke, 17(1), 59-66. https://doi.org/10.1177/1747493021995590

Background Functional neurological disorder is defined by symptoms not explained by the current model of disease and its pathophysiology. It is found in 8.4% of patients presenting as acute stroke. Treatment is difficult and recurrence rates are high... Read More about The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK.

4 Gy versus 24 Gy radiotherapy for follicular and marginal zone lymphoma (FoRT): long-term follow-up of a multicentre, randomised, phase 3, non-inferiority trial (2021)
Journal Article
Hoskin, P., Popova, B., Schofield, O., Brammer, C., Robinson, M., Brunt, A. M., …Kirkwood, A. A. (2021). 4 Gy versus 24 Gy radiotherapy for follicular and marginal zone lymphoma (FoRT): long-term follow-up of a multicentre, randomised, phase 3, non-inferiority trial. Lancet Oncology, 22(3), 332-340. https://doi.org/10.1016/S1470-2045%2820%2930686-0

BACKGROUND: The optimal radiotherapy dose for indolent non-Hodgkin lymphoma is uncertain. We aimed to compare 24 Gy in 12 fractions (representing the standard of care) with 4 Gy in two fractions (low-dose radiation). METHODS: FoRT (Follicular Radioth... Read More about 4 Gy versus 24 Gy radiotherapy for follicular and marginal zone lymphoma (FoRT): long-term follow-up of a multicentre, randomised, phase 3, non-inferiority trial.

Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players. (2021)
Journal Article
(2021). Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players. Orthopaedic Journal of Sports Medicine, https://doi.org/10.1177/2325967120979994

Background: Professional soccer players are often evaluated with asymptomatic lesions of the ankle and foot, and such abnormalities may eventually become clinically relevant. Purpose: To ascertain the prevalence of foot and ankle abnormalities in eli... Read More about Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players..

Nanoscale chemical speciation of ß-amyloid/iron aggregates using soft x-ray spectromicroscopy (2021)
Journal Article
Everett, J., Brooks, J., Collingwood, J. F., & Telling, N. (2021). Nanoscale chemical speciation of ß-amyloid/iron aggregates using soft x-ray spectromicroscopy. Inorganic Chemistry Frontiers, 8(6), 1439-1448. https://doi.org/10.1039/D0QI01304H

Iron (Fe) is an essential trace element required for healthy brain function. Yet, disrupted iron neurochemistry, and the associated formation of aberrantly aggregated protein lesions has been implicated in the development of multiple degenerative bra... Read More about Nanoscale chemical speciation of ß-amyloid/iron aggregates using soft x-ray spectromicroscopy.

Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach? (2021)
Journal Article
Garcia, J., McCarthy, H. S., Kuiper, J. H., Melrose, J., & Roberts, S. (2021). Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?. Biomolecules, 11(1), Article ARTN 92. https://doi.org/10.3390/biom11010092

Articular cartilage is considered to have limited regenerative capacity, which has led to the search for therapies to limit or halt the progression of its destruction. Perlecan, a multifunctional heparan sulphate (HS) proteoglycan, promotes embryonic... Read More about Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?.

An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C. (2021)
Journal Article
Reynisson. (2021). An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C. Analytical Methods, https://doi.org/10.1039/D0AY02208J

The Bacillus cereus phosphatidylcholine-specific phospholipase C (PC-PLCBc) is an enzyme that catalyses the hydrolysis of phosphatidylcholines into phosphocholine and 1,2-diacylglycerols. PC-PLCBc has found applications in both the food industry and... Read More about An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C..

Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines (2021)
Journal Article
Parfitt, C., Duff, C. J., Scargill, J., Green, L., Holland, D., Heald, A. H., & Fryer, A. A. (2021). Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines. BMC Psychiatry, 21, Article 32. https://doi.org/10.1186/s12888-020-03023-y

BACKGROUND: Bipolar disorder is the fourth most common mental health condition, affecting ~?1% of UK adults. Lithium is an effective treatment for prevention of relapse and hospital admission, and is widely recommended as a first-line treatment. We p... Read More about Serum lithium test requesting across three UK regions: an evaluation of adherence to monitoring guidelines.

Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes. (2021)
Journal Article
(2021). Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-020-03725-8

INTRODUCTION: The role of tourniquet during knee arthroplasty is controversial. The present study compares various tourniquet protocols using a Bayesian network meta-analysis of peri-operative data. MATERIAL AND METHODS: The present study was con... Read More about Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes..

Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration (2021)
Journal Article
(2021). Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration. Journal of Functional Morphology and Kinesiology, 1-32. https://doi.org/10.3390/jfmk6010006

Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature. There is... Read More about Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration.

Supercritical emulsion extraction fabricated PLA/PLGA micro/nano carriers for growth factor delivery: Release profiles and cytotoxicity. (2021)
Journal Article
(2021). Supercritical emulsion extraction fabricated PLA/PLGA micro/nano carriers for growth factor delivery: Release profiles and cytotoxicity. International Journal of Pharmaceutics, 120108 - ?. https://doi.org/10.1016/j.ijpharm.2020.120108

Controlled delivery of human growth factors is still a challenge in tissue engineering protocols, and poly-lactic acid and poly-lactic-co-glycolic acid carriers have been recently proposed for this purpose. Here, the microencapsulation of two human g... Read More about Supercritical emulsion extraction fabricated PLA/PLGA micro/nano carriers for growth factor delivery: Release profiles and cytotoxicity..

The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures (2021)
Journal Article
Andersen, C., Wragg, N., Shariatzadeh, M., & Wilson, S. L. (2021). The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures. Current Osteoporosis Reports, 19, 1-14. https://doi.org/10.1007/s11914-020-00643-x

PURPOSE OF REVIEW: The treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platele... Read More about The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.

Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE) (2021)
Journal Article
Yang. (2021). Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE). Biomedical Optics Express, 588 - 603. https://doi.org/10.1364/BOE.404096

Corneal wound healing, caused by frequent traumatic injury to the cornea and increasing numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound healing is an extremely complicated process. However, little is known a... Read More about Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).