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All Outputs (101)

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. (2022). A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.

Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD) (2022)
Thesis
Scott, N. (2022). Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD). (Thesis). Keele University

Objectives: Observational studies of polypharmacy and the risk of death or ischaemic stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings. The reason for this variation may be due to differences in study designs and... Read More about Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD).

Use of nanoparticles to improve the therapeutic index of navitoclax (2022)
Thesis
Alrosan, K. J. J. A. (2022). Use of nanoparticles to improve the therapeutic index of navitoclax. (Thesis). Keele University

Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of t... Read More about Use of nanoparticles to improve the therapeutic index of navitoclax.

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

Muscle herniae: Conservative and surgical management. Systematic review (2022)
Journal Article
Quaranta, M., Poeta, N., Oliva, F., & Maffulli, N. (2023). Muscle herniae: Conservative and surgical management. Systematic review. Surgeon, 21(3), 181-189. https://doi.org/10.1016/j.surge.2022.02.003

Background Muscle herniae are often unrecognized. The primary objective of this systematic review is to evaluate the outcomes of conservative and surgical management for muscle herniae. The secondary objective is to define the most appropriate manag... Read More about Muscle herniae: Conservative and surgical management. Systematic review.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improves key h... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA (2022)
Journal Article
Edwards-Smallbone, J., L. Jensen, A., E. Roberts, L., Isidore G. Totanes, F., Hart, S., & J. Merrick, C. (2022). Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA. Frontiers in Cellular and Infection Microbiology, 12, https://doi.org/10.3389/fcimb.2022.782537

In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.... Read More about Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA.

Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic (2022)
Journal Article
(2022). Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic. Advances in therapy, https://doi.org/10.1007/s12325-022-02056-x

The COVID-19 pandemic has brought a renewed focus on appropriate management of chronic respiratory conditions with a heightened awareness of respiratory symptoms and the requirement for differential diagnosis between an asthma attack and COVID-19 inf... Read More about Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic.

Minimally invasive fasciotomy for symptomatic tibialis anterior muscle hernia (2022)
Journal Article
Maffulli, N., Quaranta, M., Poeta, N., Oliva, F., Padhiar, N., & Chan, O. (2023). Minimally invasive fasciotomy for symptomatic tibialis anterior muscle hernia. Surgeon, 21(2), e63-e70. https://doi.org/10.1016/j.surge.2022.01.005

Background Symptomatic muscle herniae are an uncommon cause of chronic exercise induced leg pain. The most common site for muscle hernia is the tibialis anterior muscle. This study evaluates the outcome of a minimal incision fasciotomy in patients w... Read More about Minimally invasive fasciotomy for symptomatic tibialis anterior muscle hernia.

N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties (2022)
Journal Article
Al-Riyahee, A. A. A., Horton, P. N., Coles, S. J., Berry, C., Horrocks, P. D., Pope, S. J. A., & Amoroso, A. J. (2022). N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties. Dalton Transactions, 51(9), 3531-3545. https://doi.org/10.1039/d1dt04091j

The synthesis of six N,N'-substituted thiourea ligands (L1a-L3b) was achieved in two steps. A corresponding extensive series of Cu(I), Cu(II), Ni(II) and Zn(II) complexes (1-24) with varying formulations were synthesised from these ligands by the rea... Read More about N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties.

What can Jane Goodall teach us about addiction? (2022)
Journal Article
Frisher. (2023). What can Jane Goodall teach us about addiction?. Drugs: Education, Prevention, and Policy, 30(1), 55-59. https://doi.org/10.1080/09687637.2022.2033164

In 2017, Jane Goodall, the well-known primatologist, wrote a letter to the United States Food and Drug Administration criticising the use of animals to test brain-based theories of addiction. She reasoned that we already know about addiction by obser... Read More about What can Jane Goodall teach us about addiction?.

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. (2022)
Journal Article
Reynisson. (2022). Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules, 1-14. https://doi.org/10.3390/molecules27030880

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in... Read More about Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action..

Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. (2022)
Journal Article
Reynisson. (2022). Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. Molecules, https://doi.org/10.3390/molecules27030817

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HS... Read More about Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70..

Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review (2022)
Journal Article
Jacklin, Maidment, I., Wong, G., Duddy, C., Upthegrove, R., Oduola, S., …MacPhee, M. (2022). Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review. BMJ Open, 12(1), e058524 - ?. https://doi.org/10.1136/bmjopen-2021-058524

INTRODUCTION: Severe mental illness (SMI) is associated with significant morbidity and mortality. People living with SMI often receive complex medication regimens. Optimising these regimens can be challenging. Non-adherence is common and addressing i... Read More about Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review.

Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial (2022)
Journal Article
Tunnage, B., Woodhouse, L. J., Dixon, M., Anderson, C., Ankolekar, S., Appleton, J., …Investigators, R. (in press). Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial. BMC Emergency Medicine, 22, Article 2. https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial.

Prognostic factors in the management of osteonecrosis of the femoral head: A systematic review (2022)
Journal Article
Migliorini, F., Maffulli, N., Baroncini, A., Eschweiler, J., Tingart, M., & Betsch, M. (2023). Prognostic factors in the management of osteonecrosis of the femoral head: A systematic review. Surgeon, 21(2), 85-98. https://doi.org/10.1016/j.surge.2021.12.004

Background Several hip preserving techniques have been described for the management of osteonecrosis of the femoral head (ONFH). This systematic review identified prognostic factors in the treatment of ONFH that are associated with treatment failure... Read More about Prognostic factors in the management of osteonecrosis of the femoral head: A systematic review.

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM (2022)
Journal Article
Mottershead, D. (2022). Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM. Journal of Assisted Reproduction and Genetics, 39, Article 127–140. https://doi.org/10.1007/s10815-021-02382-z

PURPOSE: In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for certain patient grou... Read More about Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM.