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All Outputs (6)

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417500

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core (2020)
Thesis
Jihad, T. W. J. Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416566

Calix[4]resorcinarenes functionalised with glycosidic ligands on their lower rim have received little interest compared to analogues bearing carbohydrates on the upper rim. In this study, series of novel macrocyclic glycoclusters bearing mono- or dis... Read More about Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core.

Development of a novel doxorubicin delivery system for pancreatic cancer (2020)
Thesis
Al-Ameri, J. J. M. Development of a novel doxorubicin delivery system for pancreatic cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/416228

Pancreatic cancer is considered as the 4th most aggressive cancer in the Western world. There is a direct link between
pancreatic cancer diagnosis and patient age with high occurrence of the disease happening in the 65-75-year age group. The majori... Read More about Development of a novel doxorubicin delivery system for pancreatic cancer.

The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy (2018)
Thesis
AL-Shakarchi, W. The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411465

Hepatocellular carcinoma accounts for 85% of primary liver cancer that are usually characterised by defective or ineffective apoptosis which is considered to be the main cause of cancer progression. In this study, Cytochrome-C which is a pro-apoptoti... Read More about The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy.

Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology (2018)
Thesis
Jamur, J. M. S. Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410303

A novel method for monitoring of pharmaceutically relevant reactions using PADI-MS has been developed in this study. The visible non-thermal plasma plume from a coaxial helium gas flow non-thermal RF plasma was optimised using a range of samples. PAD... Read More about Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology.