All Outputs (6)

Screening of an open-source compound library against the livestock parasite Trypanosoma evansi (2024)
Thesis
Ansah, M. L. K. (2024). Screening of an open-source compound library against the livestock parasite Trypanosoma evansi. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853242

Surra is a neglected tropical veterinary disease that causes a large socioeconomic burden in sub-Saharan Africa, South America, the middle east, Asia, and parts of Southern Europe. Although symptoms can be mild in wild animal species, disease in dome... Read More about Screening of an open-source compound library against the livestock parasite Trypanosoma evansi.

Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay (2023)
Thesis
Freakley, A. L. (2023). Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay. (Thesis). Keele University

Leishmaniasis is a neglected tropical disease associated with poverty, deprived socio-economic settings and population displacement, primarily due to conflict. The causative agent are species of Leishmania parasites that are transmitted by sand flies... Read More about Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay.

ARF regulating proteins as novel drug targets in Trypanosoma brucei (2020)
Thesis
Chandrathas, J. P. (2020). ARF regulating proteins as novel drug targets in Trypanosoma brucei. (Thesis). Keele University

Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases that pose a huge socioeconomic and health burden in poorer countries in sub-Saharan Africa. The causative agents of these diseases are the Tr... Read More about ARF regulating proteins as novel drug targets in Trypanosoma brucei.

Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models (2019)
Thesis
Andoh, N. E. (2019). Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413819

During cerebral malaria (CM), sequestration of Plasmodium falciparum infected red blood cells (PRBC) to the blood-brain barrier (BBB) is associated with BBB disruption and long-term neurological sequelae in CM survivors, possibly linked to the activa... Read More about Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models.

An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries (2019)
Thesis
Hameed, H. N. (2019). An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413079

Using a novel library of natural products isolated from temperate zone plants, the antiparasitic activity of 643 Phytopure library compounds were determined against intraerytrocytic P. falciparum, the blood-stream form of T. b brucei and axenic amast... Read More about An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries.

An investigation into the role of protein phosphatase 4 in breast cancer (2018)
Thesis
Mohammed, H. N. (2018). An investigation into the role of protein phosphatase 4 in breast cancer. (Thesis). Keele University

Breast cancer is the most common malignant tumour among females world-wide. The complexity of the pathogenesis of the disease and its heterogeneous clinical presentation, with an increasing incidence of the development of chemotherapeutic resistant c... Read More about An investigation into the role of protein phosphatase 4 in breast cancer.