All Outputs (7)

Investigating the biological activities of glycosaminoglycan mimetics against the Alzheimer’s associated proteins BACE1 and ApoE (2025)
Thesis
Pinter, E. A. M. (2025). Investigating the biological activities of glycosaminoglycan mimetics against the Alzheimer’s associated proteins BACE1 and ApoE. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1279750

Alzheimer's disease (AD) is the most common form of dementia affecting approximately 44 million people worldwide. Current treatments are surrounded by limitations; cholinesterase inhibitors and memantine are not preventative and only mask symptoms, a... Read More about Investigating the biological activities of glycosaminoglycan mimetics against the Alzheimer’s associated proteins BACE1 and ApoE.

ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control (2023)
Thesis
Devlin, A. J. ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control. (Thesis). Keele University. https://keele-repository.worktribe.com/output/518613

Heparin is a member of the glycosaminoglycan (GAG) family of naturally occurring, polydisperse, linear polysaccharides. Heparin is a ubiquitous anticoagulant drug, a member of the WHO’s list of vital medicines and the second used drug by weight after... Read More about ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control.

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424531

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.

Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease (2022)
Thesis
Mycroft-West, C. J. Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease. (Thesis). Keele University. https://keele-repository.worktribe.com/output/423520

Currently, only palliative drugs are available for the treatment of Alzheimer’s disease, therefore there is an urgent need to develop therapeutics targeting the underlying aetiology of the disease. The clinical anticoagulant heparin has previously be... Read More about Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease.

Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum (2019)
Thesis
Hmoud, M. K. Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum. (Thesis). Keele University. https://keele-repository.worktribe.com/output/414945

Despite the efforts in malaria eradication and elimination, malaria still poses a global challenge to health that, through the spread of antimalarial resistance, highlights an urgent need for new approaches for malaria treatment. Heparin and sulphate... Read More about Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum.

The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula (2019)
Thesis
Pither, M. The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417815

Veillonella parvula is a Gram-negative bacterium known to be an abundant commensal coloniser of the human gut and mouth; it is linked to progression of childhood immune system but has also been found to be an opportunistic pathogen. Lipopolysaccharid... Read More about The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula.

Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development (2018)
Thesis
Hadfield, L. C. Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411146

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, ß-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research group... Read More about Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development.