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All Outputs (5)

Novel insights into the role of long non-coding RNA MIAT in leukaemia (2025)
Thesis
Ostini, A. (2025). Novel insights into the role of long non-coding RNA MIAT in leukaemia. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1280075

lncRNAs are key regulators of various cellular processes, playing significant roles in both healthy and malignant contexts, and actively contributing to carcinogenesis and cell fate determination. This study investigates the role of Myocardial Infarc... Read More about Novel insights into the role of long non-coding RNA MIAT in leukaemia.

Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival (2024)
Thesis
Maroszek, M. R. Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival. (Thesis). Keele University. https://keele-repository.worktribe.com/output/884975

Current research indicates that long noncoding RNAs orchestrate various regulatory processes in a physiological context and thereby, their dysregulation may contribute to major human diseases, including cancer (Grammatikakis et al.,2014).

Long no... Read More about Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival.

Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia (2023)
Journal Article
Ostini, A., & Mourtada-Maarabouni, M. (2023). Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia. Non-Coding RNA, 9(4), Article 47. https://doi.org/10.3390/ncrna9040047

Myocardial Infarction Associated Transcript (MIAT) is a nuclear long non-coding RNA (LncRNA) with four different splicing variants. MIAT dysregulation is associated with carcinogenesis, mainly acting as an oncogene regulating cellular growth, invasio... Read More about Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia.

Investigation into the role of long non-coding RNAs in neuroblastoma and glioma (2021)
Thesis
Bountali, A. Investigation into the role of long non-coding RNAs in neuroblastoma and glioma. (Thesis). Keele University. https://keele-repository.worktribe.com/output/419436

Long non-coding RNAs (lncRNAs) play key roles in several processes in healthy and cancer settings and the underpinning mechanisms of their action are thoroughly investigated. In line with this, this study investigates the role of the lncRNA myocardia... Read More about Investigation into the role of long non-coding RNAs in neuroblastoma and glioma.

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. (2001)
Journal Article
Zaitsev, S. V., Appelskog, I. B., Kapelioukh, I. L., Yang, S. N., Köhler, M., Efendic, S., Berggren, P. O., & Maarabouni, M. (2001). Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes, 50(suppl_1), Article S70. https://doi.org/10.2337/diabetes.50.2007.s70

Imidazoline compounds have been considered for the treatment of type 2 diabetes. We have now investigated the effects of imidazolines on interleukin (IL)-1beta-induced beta-cell apoptosis and the signal transduction pathways involved. Inhibition of C... Read More about Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis..