All Outputs (11)

Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424526

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University. https://keele-repository.worktribe.com/output/421747

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417183

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

Exploring the effects of gestational diabetes on placental membrane derived stem cells (2019)
Thesis
Chen, L.-Y. Exploring the effects of gestational diabetes on placental membrane derived stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/414443

The progression of regenerative medicine and advanced cell banking technology provide the hope of using perinatal tissue-derived autologous MSCs for personalised medicine. Mesenchymal stem cells (MSCs) derived from placenta, with the advantages of be... Read More about Exploring the effects of gestational diabetes on placental membrane derived stem cells.

Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration (2019)
Thesis
Younus, Z. M. Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration. (Thesis). Keele University. https://keele-repository.worktribe.com/output/413770

Osteochondral defects are serious clinical problems relating to damaged articular cartilage within joints, usually resulting from acute traumatic injury or an underlying bone disorder. A variety of therapeutic options have been investigated, with sev... Read More about Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy (2018)
Thesis
Abo Donia, M. N. A. Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410399

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer (2018)
Thesis
Abdullah, M. I. Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410387

Ovarian cancer is the 5th leading cause of cancer-related death. The disease responds initially to treatment which is most often surgical cytoreduction followed by chemotherapy. The primary response rates to chemotherapy are approximately 80%. Unfort... Read More about Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer.

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology (2018)
Thesis
Ahmed, M. A. Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410299

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.