All Outputs (2)

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. (2021). Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.