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Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. (2017)
Journal Article
Spiers, J., Buszewicz, M., Chew-Graham, C. A., Gerada, C., Kessler, D., Leggett, N., …Riley, R. (2017). Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. British Journal of General Practice (BJGP), 700-708. https://doi.org/10.3399/bjgp17X692573

BACKGROUND: GPs are under increasing pressure due to a lack of resources, a diminishing workforce, and rising patient demand. As a result, they may feel stressed, burnt out, anxious, or depressed. AIM: To establish what might help or hinder GPs exper... Read More about Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study..

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo (2017)
Journal Article
Llavero Hurtado, M., Fuller, H., Wong, A., Eaton, S., Gillingwater, T., Pennetta, G., …Wishart, T. (2017). Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Scientific reports, https://doi.org/10.1038/s41598-017-12603-0

Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and... Read More about Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo.

The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control (2017)
Journal Article
Dunn, K., Campbell, P., & Hope, K. (2017). The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control. Journal of Pain Research, https://doi.org/10.2147/JPR.S139445

Low back pain (LBP) is common, impacts on the individual and society, and is a major health concern. Psychological consequences of LBP, such as depression, are significant barriers to recovery, but mechanisms for the development of depression are les... Read More about The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control.

Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach? (2017)
Journal Article
Pearson, R. J. (2017). Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?. Journal of Chemical Education, 94(12), 1866-1872. https://doi.org/10.1021/acs.jchemed.7b00270

Different approaches to the use of “clickers” (also known as student response systems) were introduced to a cohort of 127 students over a two-year period with the aim of making students think more deeply in-class about their chemistry knowledge. Stud... Read More about Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?.

Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. (2017)
Journal Article
Sim, J., Bishop, J., Gray, R., and the Stroke Oxygen Study Collaborative Group, S. O. S. I., Roffe, C., Nevatte, T., …Ferdinand, P. (2017). Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. Journal of the American Medical Association, 318(12), 1125 - 1135. https://doi.org/10.1001/jama.2017.11463

Importance: Hypoxia is common in the first few days after acute stroke, is frequently intermittent, and is often undetected. Oxygen supplementation could prevent hypoxia and secondary neurological deterioration and thus has the potential to improve r... Read More about Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial..

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article
Manzur, A., Hoskins, C., Oluwasanmi, A., Moss, D., & Curtis, A. (2017). Nanotechnologies in Pancreatic Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics9040039

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Metaphysis (2017)
Journal Article
Ogrodnik, P. (2017). Metaphysis

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
Oluwasanmi, A., Al-Shakarchi, W., Manzur, A., Aldebasi, M. H., Elsini, R. S., Albusair, M. K., …Hoskins, C. (2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was develop... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
(2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Abstract Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system wa... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives (2017)
Journal Article
Plażuk, D., Wieczorek, A., Ciszewski, W. M., Kowalczyk, K., Błauż, A., Pawlędzio, S., …Rychlik, B. (2017). Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives. ChemMedChem, 12(22), 1882-1892. https://doi.org/10.1002/cmdc.201700576

Taxanes, including paclitaxel, are widely used in cancer therapy. In an attempt to overcome some of the disadvantages entailed with taxane chemotherapy, we devised the synthesis of ferrocenyl-functionalized paclitaxel derivatives and studied their bi... Read More about Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Swaithes. (2017). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-017-1761-4

Background The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences (2017)
Journal Article
Campbell, P., Jordan, K., Dunn, K., & Smith, B. (2017). Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences. PAIN, 41-47. https://doi.org/10.1097/j.pain.0000000000001062

Chronic pain is common and creates a significant burden to the individual and society. Emerging research has shown the influence of the family environment on pain outcomes. However, it is not clear what shared factors between family members associate... Read More about Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences.

Role of Strategic Partnerships in Internationalisation of Small Born Global Firms (2017)
Journal Article
(2017). Role of Strategic Partnerships in Internationalisation of Small Born Global Firms. Entrepreneurial Business and Economics Review, 49-77. https://doi.org/10.15678/EBER.2017.050303

Objective: The article discusses motives driving the internationalisation of small born global firms and explores the role strategic partnerships play in the process. It argues that born globals are forced into international markets soon after their... Read More about Role of Strategic Partnerships in Internationalisation of Small Born Global Firms.

Spectroscopic survey of Kepler stars - II. FIES/NOT observations of A- and F-type stars (2017)
Journal Article
Smalley. (2017). Spectroscopic survey of Kepler stars - II. FIES/NOT observations of A- and F-type stars. Monthly Notices of the Royal Astronomical Society, 2870 -2889. https://doi.org/10.1093/mnras/stx1256

We have analysed high-resolution spectra of 28 A and 22 F stars in the Kepler field, observed using the Fibre-Fed Échelle Spectrograph at the Nordic Optical Telescope. We provide spectral types, atmospheric parameters and chemical abundances for 50 s... Read More about Spectroscopic survey of Kepler stars - II. FIES/NOT observations of A- and F-type stars.

Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice (2017)
Journal Article
(2017). Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice. Statistics in Medicine, 3283 -3301. https://doi.org/10.1002/sim.7372

An important question for clinicians appraising a meta-analysis is: are the findings likely to be valid in their own practice-does the reported effect accurately represent the effect that would occur in their own clinical population? To this end we a... Read More about Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice.

Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics (2017)
Journal Article
Behrouz, R., Masjuán-Vallejo, J., Vera, R., Willey, J. Z., Zedet, M., Moulin, S., …Di Napoli, M. (2018). Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics. Journal of Stroke and Cerebrovascular Diseases, 27(1), 246-256. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.031

Background Nonagenarians are under-represented in thrombolytic trials for acute ischemic stroke (AIS). The effectiveness of intravenous thrombolytics in nonagenarians in terms of safety and outcome is not well established. Materials and Methods... Read More about Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics.

Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer (2017)
Journal Article
Davoodi, P., Ng, W. C., Srinivasan, M. P., & Wang, C. (2017). Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer. Biotechnology and Bioengineering, 114(12), 2931-2946. https://doi.org/10.1002/bit.26406

Triple negative breast cancer (TNBC) is an aggressive sub-type of breast cancer that rarely responds to conventional chemotherapy. Therefore, novel agents or new routes need to be developed to improve treatment efficacy and diminish severe side-effec... Read More about Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer.