Skip to main content

Research Repository

Advanced Search

All Outputs (1185)

Meta-QSAR: a large-scale application of meta-learning to drug design and discovery. (2017)
Journal Article
(2017). Meta-QSAR: a large-scale application of meta-learning to drug design and discovery. Machine Learning, 285 - 311. https://doi.org/10.1007/s10994-017-5685-x

We investigate the learning of quantitative structure activity relationships (QSARs) as a case-study of meta-learning. This application area is of the highest societal importance, as it is a key step in the development of new medicines. The standard... Read More about Meta-QSAR: a large-scale application of meta-learning to drug design and discovery..

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. (2017)
Journal Article
Van Der Windt, Holden, & Dziedzic. (2017). Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open, e018971 - ?. https://doi.org/10.1136/bmjopen-2017-018971

INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physic... Read More about Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol..

Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis (2017)
Journal Article
Kay, A., Long, G., Broadfoot, S., Piccinini, A., Middleton, J., Kehoe, O., …Stefan, A. (2017). Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis. Scientific reports, https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis.

An Infrared Census of DUST in Nearby Galaxies with Spitzer (DUSTiNGS). IV. Discovery of High-redshift AGB Analogs (2017)
Journal Article
Van Loon. (2017). An Infrared Census of DUST in Nearby Galaxies with Spitzer (DUSTiNGS). IV. Discovery of High-redshift AGB Analogs. Astrophysical Journal, https://doi.org/10.3847/1538-4357/aa9892

The survey for DUST in Nearby Galaxies with Spitzer (DUSTiNGS) identified several candidate Asymptotic Giant Branch (AGB) stars in nearby dwarf galaxies and showed that dust can form even in very metal-poor systems (${\boldsymbol{Z}}\sim 0.008\,{Z}_{... Read More about An Infrared Census of DUST in Nearby Galaxies with Spitzer (DUSTiNGS). IV. Discovery of High-redshift AGB Analogs.

The aggregation of an alkyl-C60 derivative as a function of concentration, temperature and solvent type. (2017)
Journal Article
Hollamby, M., Smith, C., Britton, M., Danks, A., Schnepp, Z., Grillo, I., …Nakanishi, T. (2017). The aggregation of an alkyl-C60 derivative as a function of concentration, temperature and solvent type. Physical Chemistry Chemical Physics, 20(5), 3373-3380. https://doi.org/10.1039/C7CP06348B

Contrast-variation small-angle neutron scattering (CV-SANS), small-angle X-ray scattering (SAXS), nuclear magnetic resonance (NMR) measurements of diffusion and isothermal titration calorimetry (ITC) are used to gain insight into the aggregation of a... Read More about The aggregation of an alkyl-C60 derivative as a function of concentration, temperature and solvent type..

Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study (2017)
Journal Article
Mamas. (2017). Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study. Journal of epidemiology and community health, 140-147. https://doi.org/10.1136/jech-2017-209999

Background: Socio-economic deprivation is a key determinant for health. In England, the Index of Multiple Deprivation (IMD) is a widely used composite measure of deprivation. However, little is known about its spatial clustering or persistence acros... Read More about Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study.

Turning Models Inside Out (2017)
Journal Article
(2017). Turning Models Inside Out. CEUR Workshop Proceedings,

We present an approach for change-based (as opposed to state-based) model persistence that can facilitate highperformance incremental model processing (e.g. validation, transformation) by minimising the cost of change identification when models evolv... Read More about Turning Models Inside Out.

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents. (2017)
Journal Article
Reynisson. (2017). GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules, https://doi.org/10.3390/molecules22122254

A panel of docking scaffolds was developed for the known molecular targets of the anticancer agents, thieno[2,3-b]pyridines, in order to glean insight into their mechanism of action. The reported targets are the copper-trafficking antioxidant 1 prote... Read More about GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents..

Reconstruction of linear dunes from ancient aeolian successions using subsurface data: Permian Auk Formation, Central North Sea, UK (2017)
Journal Article
(2017). Reconstruction of linear dunes from ancient aeolian successions using subsurface data: Permian Auk Formation, Central North Sea, UK. Marine and Petroleum Geology, https://doi.org/10.1016/j.marpetgeo.2017.12.021

A series of well logs and cores penetrating the predominantly aeolian Auk Formation, Permian Rotliegend Group, Central North Sea, UK, have been evaluated to determine the morphology and style of migratory behaviour of the original dune bedforms, the... Read More about Reconstruction of linear dunes from ancient aeolian successions using subsurface data: Permian Auk Formation, Central North Sea, UK.

Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour (2017)
Journal Article
Finney, A., Dziedzic, K., Lewis, A., & Healey, E. (2017). Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour. BMC Musculoskeletal Disorders, 18, Article 535. https://doi.org/10.1186/s12891-017-1896-3

Background
Research into musculoskeletal conditions often focusses on pain at single sites, such as the knee, yet several studies have previously reported the high prevalence of multiple sites of musculoskeletal pain. The most common form of musculo... Read More about Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

Is Trade in Permits Good for the Environment? (2017)
Journal Article
Lapan, H., & Sikdar, S. (2017). Is Trade in Permits Good for the Environment?. Environmental and Resource Economics, 500-510. https://doi.org/10.1007/s10640-017-0202-z

We analyze the impact of trade in emission permits on environmental policy when countries trade a differentiated good. Pollution is always higher with tradable permits as compared to the case where permits are not internationally tradable. If polluti... Read More about Is Trade in Permits Good for the Environment?.

Development of an individualised, supervised and progressed therapist led exercise programme for Plantar Heel Pain (Plantar Fasciitis) (2017)
Journal Article
Humphreys, K., Larkin, T., Chesterton, L., Thomas, M., Roddy, E., Hendry, G., …Thomas, M. (2017). Development of an individualised, supervised and progressed therapist led exercise programme for Plantar Heel Pain (Plantar Fasciitis). Physiotherapy, 103(S1), e145-e146. https://doi.org/10.1016/j.physio.2017.11.140

Purpose: To describe the development, and content of a physiotherapist and podiatrist led individualised, supervised and progressed exercise programme for use in a feasibility and pilot randomised controlled trial (RCT) testing interventions for Plan... Read More about Development of an individualised, supervised and progressed therapist led exercise programme for Plantar Heel Pain (Plantar Fasciitis).

Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort (2017)
Journal Article
Masson, W., Muller, S., Whittle, R., Prior, J., Helliwell, T., Mallen, C., & Hider, S. (2017). Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort. BMC Rheumatology, 1, Article 7. https://doi.org/10.1186/s41927-017-0007-2

Background: To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Me... Read More about Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort.

What Pollock and Rothko may have announced and Restorative Justice may have to deal with: sovereign victim culture (2017)
Journal Article
(2017). What Pollock and Rothko may have announced and Restorative Justice may have to deal with: sovereign victim culture. Restorative Justice, 455-467. https://doi.org/10.1080/20504721.2017.1392777

A close reading of EU Directive 2012/29/EU of 25 October 2012 (EU Member States to comply by 16 November 2015), ‘establishing minimum standards on the rights, support and protection of victims of crime’, may reveal that a particular image of victimho... Read More about What Pollock and Rothko may have announced and Restorative Justice may have to deal with: sovereign victim culture.