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Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining (2018)
Journal Article
(2018). Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining. Scientific Data, https://doi.org/10.1038/sdata.2018.213

DNA methylation is an important epigenetic modification that can regulate gene expression following environmental encounters without changes to the genetic code. Using Infinium MethylationEPIC BeadChip Arrays (850,000 CpG sites) we analysed for the f... Read More about Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining.

Water treatment residuals as soil amendments: Examining element extractability, soil porewater concentrations and effects on earthworm behaviour and survival (2018)
Journal Article
Howells, A., Lewis, S., Beard, D., & Oliver, I. (2018). Water treatment residuals as soil amendments: Examining element extractability, soil porewater concentrations and effects on earthworm behaviour and survival. Ecotoxicology and Environmental Safety, https://doi.org/10.1016/j.ecoenv.2018.06.087

Drinking water treatment residuals (WTRs), the by-product of water clarification processes, are routinely disposed of via landfill however there is a growing body of research that demonstrates the material has great potential for beneficial use in en... Read More about Water treatment residuals as soil amendments: Examining element extractability, soil porewater concentrations and effects on earthworm behaviour and survival.

Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. (2018)
Journal Article
Kadam, U. T., Roberts, I., White, S., Bednall, R., Khunti, K., Nilsson, P. M., & Lawson, C. A. (2019). Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. Journal of Clinical Epidemiology, 106, 98-107. https://doi.org/10.1016/j.jclinepi.2018.10.014

With older and ageing populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple... Read More about Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy..

Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. (2018)
Journal Article
Protheroe. (2018). Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. Disability and Rehabilitation, 1 - 9. https://doi.org/10.1080/09638288.2018.1485182

BACKGROUND: This study recorded the functional health literacy levels of people with musculoskeletal (MSK) conditions from harder to reach groups and explored their experiences in engaging with health care professionals to self-manage their MSK condi... Read More about Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study..

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

Enhanced methane reforming activity of a hydrothermally synthesised co-doped perovskite catalyst (2018)
Journal Article
Khazaal, M. H., Staniforth, J. Z., Alfatlawi, Z. A., Ormerod, R. M., & Darton, R. (2018). Enhanced methane reforming activity of a hydrothermally synthesised co-doped perovskite catalyst. Energy and Fuels, 32(12), 12826–12832. https://doi.org/10.1021/acs.energyfuels.8b02848

A catalyst for the direct reforming of methane and simulated biogas has been prepared using a green and low temperature hydrothermal method. The nickel and iron co-doped SrZrO3 perovskite shows catalytic activity comparable to 10% Ni/Al2O3, but with... Read More about Enhanced methane reforming activity of a hydrothermally synthesised co-doped perovskite catalyst.

The humanistic and economic burden of chronic wounds: A systematic review (2018)
Journal Article
Olsson, M., Jarbrink, K., Divakar, U., Bajpai, R., Upton, Z., Schmidtchen, A., & Car, J. (2019). The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair and Regeneration, 27(1), 114 -125. https://doi.org/10.1111/wrr.12683

Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were co... Read More about The humanistic and economic burden of chronic wounds: A systematic review.

miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA (2018)
Journal Article
Shang, J., He, Q., Chen, Y., Yu, D., Sun, L., Cheng, G., …Zhao, Z. (2019). miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA. Journal of Cellular Physiology, 234(6), 9746-9755. https://doi.org/10.1002/jcp.27660

Long-term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum... Read More about miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA.

The disclosure of alleged child sexual abuse: an investigation of criminal court transcripts from Scotland (2018)
Journal Article
Skinner, G. C., Andrews, S. J., & Lamb, M. E. (2019). The disclosure of alleged child sexual abuse: an investigation of criminal court transcripts from Scotland. Psychology, Crime and Law, 25(5), 458-481. https://doi.org/10.1080/1068316x.2018.1538415

This study systematically assessed children’s disclosure processes and lawyers’ questioning about children’s disclosures in the courtroom. We analysed transcripts of 72 trials in which 5- to 17-year-old children testified as alleged victims of sexual... Read More about The disclosure of alleged child sexual abuse: an investigation of criminal court transcripts from Scotland.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris) (2018)
Journal Article
(2018). Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris). PloS one, https://doi.org/10.1371/journal.pone.0204612

Gut microbial communities are critical for the health of many insect species. However, little is known about how gut microbial communities respond to anthropogenic changes and how such changes affect host-pathogen interactions. In this study, we used... Read More about Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris).

Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes (2018)
Journal Article
Riley, R. D., Snell, K. I. E., Ensor, J., Burke, D. L., Harrell, F. E., Moons, K. G. M., & Collins, G. S. (2019). Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes. Statistics in Medicine, 38(7), 1276-1296. https://doi.org/10.1002/sim.7992

When designing a study to develop a new prediction model with binary or time-to-event outcomes, researchers should ensure their sample size is adequate in terms of the number of participants (n) and outcome events (E) relative to the number of predic... Read More about Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes.

Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation (2018)
Journal Article
(2018). Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation. Scientific reports, https://doi.org/10.1038/s41598-018-33281-6

Nebulin is a very large protein required for assembly of the contractile machinery in muscle. Mutations in the nebulin gene NEB are a common cause of nemaline myopathy. Nebulin mRNA is alternatively-spliced so that each mRNA contains either exon 143... Read More about Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation.

Non-standard s-process in massive rotating stars (2018)
Journal Article
Hirschi, R. (2018). Non-standard s-process in massive rotating stars. Astronomy and Astrophysics, https://doi.org/10.1051/0004-6361/201833283

Context Recent studies show that rotation significantly affects the s-process in massive stars. Aims We provide tables of yields for non-rotating and rotating massive stars between 10 and 150 M? at Z = 10-3 ([Fe/H] = -1.8). Tables for different... Read More about Non-standard s-process in massive rotating stars.

Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study (2018)
Journal Article
Maskell, K., McDonald, P., & Paudyal, P. (2018). Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study. British Journal of General Practice (BJGP), 68(677), e869-e876. https://doi.org/10.3399/bjgp18x699773

Background Health education materials (HEMs) are widely used in general practice. However, there is little information on the variety of HEMs currently available to patients in the UK, or their preferences for accessing educational materials. Aim... Read More about Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study.

Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. (2018)
Journal Article
(2018). Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. Malaria Journal, 377. https://doi.org/10.1186/s12936-018-2530-z

BACKGROUND: In a context of increasing resistance of both vectors toward main classes of insecticides used in public health and parasites toward anti-malarial drugs, development of new and complementary molecules or control approaches is fundamental... Read More about Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density..

‘I want the student to write my prescription’ (2018)
Journal Article
Kinston, R., McCarville, N., & Hassell, A. (2018). ‘I want the student to write my prescription’. Medical Education, 52(11), 1197-1198. https://doi.org/10.1111/medu.13718

What problems were addressed? Competence in prescribing is a core clinical skill required by all newly graduated doctors. Despite this, new doctors report relatively low levels of confidence in their prescribing skills and errors have been identifie... Read More about ‘I want the student to write my prescription’.