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All Outputs (1295)

The role of purple pens in learning to prescribe. (2019)
Journal Article
Hassell. (2019). The role of purple pens in learning to prescribe. Clinical Teacher, 598-603. https://doi.org/10.1111/tct.12991

BACKGROUND: Medical doctors are required to prescribe drugs safely and effectively upon qualification, a skill that many feel poorly prepared to undertake. To better prepare doctors, a whole-task approach that develops knowledge and skills, but that... Read More about The role of purple pens in learning to prescribe..

The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. (2019)
Journal Article
Mamas, & Nolan. (2019). The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. Heart, Lung and Circulation, 1827-1834. https://doi.org/10.1016/j.hlc.2018.11.006

BACKGROUND: Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of... Read More about The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation..

Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy (2019)
Journal Article
Chepanova, A. A., Li-Zhulanov, N. S., Sukhikh, A. S., Zafar, A., Reynisson, J., Zakharenko, A. L., …Lavrik, O. I. (2019). Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy. Bioorganicheskaya Khimiya / Russian Journal of Bioorganic Chemistry, 45(6), 647-655. https://doi.org/10.1134/s1068162019060104

Comparison of Outcomes After Percutaneous Coronary Interventions in Patients of Eighty Years and Above Compared With Those Less Than 80 Years (2019)
Journal Article
Al-khadra, Y., Kajy, M., Idris, A., Darmoch, F., Pacha, H. M., Kabach, A., …Alraies, M. C. (2019). Comparison of Outcomes After Percutaneous Coronary Interventions in Patients of Eighty Years and Above Compared With Those Less Than 80 Years. American Journal of Cardiology, 124(9), 1372-1379. https://doi.org/10.1016/j.amjcard.2019.07.055

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion (2019)
Journal Article
Blythe, N. M., Muraki, K., Ludlow, M. J., Stylianidis, V., Gilbert, H. T., Evans, E. L., …Turner, N. A. (2019). Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294(46), 17395-17408. https://doi.org/10.1074/jbc.ra119.009167

Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry (2019)
Journal Article
Mamas. (2019). Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.119.013786

Background Guidelines recommend heart team discussion and coronary artery bypass graft consideration in patients with proximal left anterior descending (LAD) artery stenosis. Evidence suggests that outcomes of proximal LAD angioplasty might not diffe... Read More about Proximal Left Anterior Descending Artery Treatment Using a Bioresorbable Polymer Coating Sirolimus-Eluting Stent: Real-World Outcomes From the Multicenter Prospective e-Ultimaster Registry.

Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore (2019)
Journal Article
Sathish, T., Dunleavy, G., Soljak, M., Visvalingam, N., Divakar, U., Thach, T., …Car, J. (2019). Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore. International Journal of Environmental Research and Public Health, 16(22), 1-11. https://doi.org/10.3390/ijerph16224551

We aimed to examine the behavioural and clinical risk factors for non-communicable diseases (NCDs) at baseline and their changes over 12 months in a workplace cohort in Singapore. A total of 464 full-time employees (age = 21 years) were recruited fro... Read More about Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore.

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. (2019)
Journal Article
Reynisson. (2019). Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorganic and Medicinal Chemistry, 115234 - ?. https://doi.org/10.1016/j.bmc.2019.115234

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced w... Read More about Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening..

Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio) (2019)
Journal Article
(2019). Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio). Journal of Fish Biology, https://doi.org/10.1111/jfb.14222

ß-glucans are frequently included in the diet of healthy common carp Cyprinus carpio as a pre-emptive measure for combatting disease. In order to study the effect this has on the relationship between the gut bacteria and host immune response, carp we... Read More about Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio).

Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP. (2019)
Journal Article
Mamas, & Rashid. (2019). Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP. International Journal of Cardiology, 7 - 13. https://doi.org/10.1016/j.ijcard.2019.11.146

BACKGROUND: International guidelines recommend that for NSTEMI, the timing of invasive strategy (IS) is a function of patient's baseline risk. The extent to which this is delivered across and within healthcare systems is unknown. METHODS: Data were d... Read More about Baseline risk, timing of invasive strategy and guideline compliance in NSTEMI: Nationwide analysis from MINAP..

Effective drain care and management in community settings. (2019)
Journal Article
Lillie. (2019). Effective drain care and management in community settings. Nursing Standard, https://doi.org/10.7748/ns.2019.e11389

The literature indicates that drain monitoring is a frequently undervalued aspect of patient care, and that the drain care provided is often inconsistent and inadequate. There are numerous potential implications of suboptimal drain care for patients,... Read More about Effective drain care and management in community settings..

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening (2019)
Journal Article
Reynisson. (2019). Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. Molecules, https://doi.org/10.3390/molecules24234346

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients' immune systems, leading to poor disease outcomes.... Read More about Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Musculoskeletal consultations from childhood to adulthood: a longitudinal study (2019)
Journal Article
Bhayankaram, N. P., Lacey, R. J., Barnett, L. A., Jordan, K. P., & Dunn, K. M. (2019). Musculoskeletal consultations from childhood to adulthood: a longitudinal study. Journal of Public Health, 42(4), e428–e434. https://doi.org/10.1093/pubmed/fdz141

BACKGROUND: The Global Burden of Disease reports indicate that musculoskeletal conditions are important causes of disability worldwide. Such conditions may originate in childhood, but studies investigating changes longitudinally and from childhood to... Read More about Musculoskeletal consultations from childhood to adulthood: a longitudinal study.