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All Outputs (1405)

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae (2020)
Journal Article
Simoni, A., Hammond, A. M., Beaghton, A. K., Galizi, R., Taxiarchi, C., Kyrou, K., …Crisanti, A. (2020). A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nature Biotechnology, https://doi.org/10.1038/s41587-020-0508-1

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce uni... Read More about A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae.

Escalation triggers and expected responses in obstetric early warning systems used in UK consultant-led maternity units (2020)
Journal Article
Cheshire, J., Lissauer, D., Parry-Smith, W., Tobias, A., Smith, G. B., Isaacs, R., & Hundley, V. (in press). Escalation triggers and expected responses in obstetric early warning systems used in UK consultant-led maternity units. Resuscitation Plus, 5, Article 100060. https://doi.org/10.1016/j.resplu.2020.100060

Background The use of obstetric early warning systems (OEWS) are recommended as an adjunct to reduce maternal morbidity and mortality. The aim of this review was to document the variation in OEWS trigger thresholds and the quality of information inc... Read More about Escalation triggers and expected responses in obstetric early warning systems used in UK consultant-led maternity units.

Self‐efficacy as a prognostic factor and treatment moderator in chronic musculoskeletal pain patients attending pain management programmes: A systematic review (2020)
Journal Article
Hayward, R., & Stynes, S. (2021). Self‐efficacy as a prognostic factor and treatment moderator in chronic musculoskeletal pain patients attending pain management programmes: A systematic review. Musculoskeletal Care, 19(3), 278-292. https://doi.org/10.1002/msc.1533

Evidence on the effectiveness of pain management programmes (PMPs) for chronic pain patients is mixed. Self-efficacy may be associated with outcome of PMPs. The purpose of this systematic review was to assess the role of self-efficacy as a (i) progno... Read More about Self‐efficacy as a prognostic factor and treatment moderator in chronic musculoskeletal pain patients attending pain management programmes: A systematic review.

Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. (2020)
Journal Article
Gómez-Gálvez, Y., & Gates, M. (2020). Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. Journal of Neuroscience Methods, 109065 - ?. https://doi.org/10.1016/j.jneumeth.2020.109065

BACKGROUND: Primary embryonic ventral mesencephalic (VM) cultures are a high throughput tool for understanding and manipulating dopamine neurons, to study the mechanisms that trigger their degeneration during Parkinson's disease (PD), and to test new... Read More about Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons..

Indicators of dementia disease progression in primary care: an electronic health record cohort study (2020)
Journal Article
Rathod-Mistry, T., Marshall, M., Campbell, P., Bailey, J., Chew-Graham, C. A., Croft, P., …Jordan, K. P. (2021). Indicators of dementia disease progression in primary care: an electronic health record cohort study. European Journal of Neurology, 28(5), 1499-1510. https://doi.org/10.1111/ene.14710

BACKGROUND: The objectives were to assess the feasibility and validity of using markers of dementia-related health as indicators of dementia progression in primary care, by assessing the frequency they are recorded and by testing the hypothesis they... Read More about Indicators of dementia disease progression in primary care: an electronic health record cohort study.

Exploring women's experiences of identifying, negotiating and managing perinatal anxiety: a qualitative study (2020)
Journal Article
Oh, S., Chew-Graham, C., Silverwood, V., Aksa Shaheen, S., Walsh-House, J., Sumathipala, A., & Kingstone, T. (2020). Exploring women's experiences of identifying, negotiating and managing perinatal anxiety: a qualitative study. BMJ Open, 10(12), Article e040731. https://doi.org/10.1136/bmjopen-2020-040731

OBJECTIVES: Anxiety affects around 15% of women during the perinatal period and can adversely impact both mother and child, with potential implications for long-term health; few studies have examined women's experiences of perinatal anxiety (PNA). In... Read More about Exploring women's experiences of identifying, negotiating and managing perinatal anxiety: a qualitative study.

A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis. (2020)
Journal Article
Ramos-Petersen, L., Nester, C. J., Reinoso-Cobo, A., Nieto-Gil, P., Ortega-Avila, A. B., & Gijon-Nogueron, G. (2021). A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis. Medicina, 57(1), Article ARTN 23. https://doi.org/10.3390/medicina57010023

Background and objective: Ninety percent of patients with rheumatoid arthritis (RA) feel foot pain during the disease process. Pharmacological treatment of RA has a systematic effect on the body and includes: Nonsteroidal anti-inflammatory drugs, dis... Read More about A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis..

Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum) (2020)
Journal Article
(2020). Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum). Conservation Physiology, coaa117 - ?. https://doi.org/10.1093/conphys/coaa117

The white rhinoceros (Ceratotherium simum) is experiencing unsustainable poaching losses fuelled by a demand for horn. Increasingly, private and state reserves are dehorning their rhinoceros populations in an attempt to reduce poaching pressure. Rhin... Read More about Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum).

Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes. (2020)
Journal Article
Roddy, & Mamas. (2020). Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes. American Journal of Cardiovascular Drugs, https://doi.org/10.1007/s40256-020-00459-1

Hyperuricemia and gout have been linked to an increased risk for cardiovascular (CV) disease, stroke, hypertension, heart failure, and chronic kidney disease, possibly through a proinflammatory milieu. However, not all the drugs used in gout treatmen... Read More about Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes..

Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline (2020)
Journal Article
Goodwin, J. W., Kruger, P. E., & Hawes, C. S. (2020). Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline. Journal of Coordination Chemistry, 74(1-3), 341-360. https://doi.org/10.1080/00958972.2020.1868041

In this work we report the coordination chemistry of a rigid heterotopic ligand 1H-pyrazolo[4,3-h]quinoline HL1 in copper(II) and zinc(II) complexes for the first time, and examine both the structural properties and solution-phase behaviour of these... Read More about Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline.

Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial (2020)
Journal Article
(2020). Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial. Clinical Rehabilitation, 269215520984025 - ?

OBJECTIVE: To investigate acceptability, barriers to adherence with the interventions, and which outcome measures best reflect the participants' rehabilitation goals in a pilot and feasibility randomised controlled trial evaluating early patient-dire... Read More about Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial.

Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. (2020)
Journal Article
Buckley, J., Riddell, M., Mellor, D., Bracken, R., Poirier, P., LaGerche, A., & Ross, M. (2020). Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2020-102446

Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are significant precursors and comorbidities to cardiovascular disease and prevalence of both types is still rising globally. Currently,~25% of participants (and rising) attending cardiac rehabilitat... Read More about Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences..

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. (2020)
Journal Article
Mamas. (2020). Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. Heart, 113-119. https://doi.org/10.1101/2020.07.14.20153734

Objective. To describe the place and causes of acute cardiovascular death during the COVID-19 pandemic. Methods. Retrospective cohort of adult (age =18 years) acute cardiovascular deaths (n=587,225) in England and Wales, 1st January 2014 to 30th Jun... Read More about Place and causes of acute cardiovascular mortality during the COVID-19 pandemic..

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A. H., Aziz, A., Alansari, R., Ferry, N., Krstic-Demonacos, M., & Ragazzon, P. (2020). Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Is GW190521 the merger of black holes from the first stellar generations? (2020)
Journal Article
Farrell, E., Groh, J. H., Hirschi, R., Murphy, L., Kaiser, E., Ekström, S., …Meynet, G. (2021). Is GW190521 the merger of black holes from the first stellar generations?. Monthly Notices of the Royal Astronomical Society, 502(1), L40-L44. https://doi.org/10.1093/mnrasl/slaa196

GW190521 challenges our understanding of the late-stage evolution of massive stars and the effects of the pair-instability in particular. We discuss the possibility that stars at low or zero metallicity could retain most of their hydrogen envelope un... Read More about Is GW190521 the merger of black holes from the first stellar generations?.

Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. (2020)
Journal Article
(2020). Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. Medicina, https://doi.org/10.3390/medicina56120715

Purpose: Nowadays, surgical treatment of acute avulsions of the Achilles tendon represents a hard challenge. There is often the possibility that the calcaneus remains completely uncovered from the tendon, making the reinsertion of its distal stub com... Read More about Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note..