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Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells (2021)
Journal Article
Luo, L., Foster, N. C., Man, K. L., Brunet, M., Hoey, D. A., Cox, S. C., Kimber, S. J., & El Haj, A. J. (2021). Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells. Biotechnology Journal, 17(4), https://doi.org/10.1002/biot.202100401

AbstractMechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiation... Read More about Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., Brown, S., Grady, K., Gadsby, R., Gibson, J. M., Paisley, A., Fryer, A. A., & Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). Endocrinology Diabetes & Metabolism, 5(2), https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., Green, L., Scargill, J., Taylor, D., & Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder.

AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models. (2021)
Journal Article
Ramspek, C. L., Teece, L., Snell, K. I. E., Evans, M., Riley, R. D., van Smeden, M., van Geloven, N., & van Diepen, M. (2021). Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models. International Journal of Epidemiology, 615-625. https://doi.org/10.1093/ije/dyab256

BACKGROUND: External validation of prognostic models is necessary to assess the accuracy and generalizability of the model to new patients. If models are validated in a setting in which competing events occur, these competing risks should be accounte... Read More about Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models..

Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. (2021)
Journal Article
Kehlenbeck, D., Traore, D. A., Josts, I., Sander, S., Moulin, M., Haertlein, M., Prevost, S., Forsyth, V. T., & Tidow, H. (2022). Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. FEBS Journal, 289(10), 2959-2970. https://doi.org/10.1111/febs.16327

The ATP-binding cassette transporter MsbA is a lipid flippase, translocating lipid A, glycolipids, and lipopolysaccharides from the inner to the outer leaflet of the inner membrane of Gram-negative bacteria. It has been used as a model system for tim... Read More about Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination..

Localized bank collapse or regional event? (2021)
Journal Article
Leslie, A., Regis, A., Clarke, S., Priddy, C., & Dodd, T. (2021). Localized bank collapse or regional event?. https://doi.org/10.31711/giw.v8.pp27-44

<jats:p>This study presents a detailed synopsis of the sedimentological and structural features displayed within an underdescribed enigmatic facies observed in the basal Lower Jurassic Kayenta Formation of the Colorado Plateau. The facies comprises p... Read More about Localized bank collapse or regional event?.

CLINICAL PROGRESSION OF LEPROSY IN EURASIAN RED SQUIRRELS (SCIURUS VULGARIS) IN A NATURALLY INFECTED WILD POPULATION (2021)
Journal Article
Schilling, A.-K., van Hooij, A., Lurz, P. W., Shaw, D. J., Geluk, A., Corstjens, P. L., Stevenson, K., & Meredith, A. L. (2021). CLINICAL PROGRESSION OF LEPROSY IN EURASIAN RED SQUIRRELS (SCIURUS VULGARIS) IN A NATURALLY INFECTED WILD POPULATION. Journal of Zoo and Wildlife Medicine, 52(4), 1159-1166. https://doi.org/10.1638/2020-0067

Leprosy has been described in Eurasian red squirrel (Sciurus vulgaris; ERS) carcasses since 2014. Studies of ERS carcasses have not provided information about incubation or disease progression in this host but have provided important insights into pa... Read More about CLINICAL PROGRESSION OF LEPROSY IN EURASIAN RED SQUIRRELS (SCIURUS VULGARIS) IN A NATURALLY INFECTED WILD POPULATION.

Dealing with impact of COVID-19 on transportation in a developing country: Insights and policy recommendations (2021)
Journal Article
Mogaji, E., Adekunle, I., Aririguzoh, S., & Oginni, A. (2022). Dealing with impact of COVID-19 on transportation in a developing country: Insights and policy recommendations. Transport Policy, 116, 304-314. https://doi.org/10.1016/j.tranpol.2021.12.002

While developed nations have established policy frameworks for dealing with various macroeconomic shocks, developing countries respond to the influx of COVID-19 on heterogeneous scales, borne out of varying institutional bottlenecks. These inadequate... Read More about Dealing with impact of COVID-19 on transportation in a developing country: Insights and policy recommendations.

Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. (2021)
Journal Article
Mamas. (2021). Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circulation: Heart Failure, e008685 - ?. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685

BACKGROUND: Heart failure has a disproportionate burden on patients who are Black, Indigenous, and people of color (BIPOC), but not much is known about representation of these groups in randomized controlled trials (RCTs). We explored temporal trends... Read More about Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review..

Families and clusters of diffuse interstellar bands: a data-driven correlation analysis (2021)
Journal Article
Van Loon. (2021). Families and clusters of diffuse interstellar bands: a data-driven correlation analysis. Monthly Notices of the Royal Astronomical Society, 3546 - 3560. https://doi.org/10.1093/mnras/stab3651

More than 500 diffuse interstellar bands (DIBs) have been observed in astronomical spectra, and their signatures and correlations in different environments have been studied over the past decades to reveal clues about the nature of the carriers. We c... Read More about Families and clusters of diffuse interstellar bands: a data-driven correlation analysis.

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., Powner, G., Waldron, J., Duff, C. J., Lea, S. C., Golash, A., Sathiavageeswaran, M., Heald, A. H., & Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

'It's always in the back of my mind': understanding the psychological impact of recovery following pancreaticoduodenectomy for cancer: a qualitative study. (2021)
Journal Article
Chew-Graham. (2021). 'It's always in the back of my mind': understanding the psychological impact of recovery following pancreaticoduodenectomy for cancer: a qualitative study. BMJ Open, e050016 - ?. https://doi.org/10.1136/bmjopen-2021-050016

OBJECTIVES: Ten per cent of patients diagnosed with pancreatic cancer undergo pancreaticoduodenectomy. There is limited previous research focusing on psychological well-being; unmet support needs impact negatively on quality of life. This paper repor... Read More about 'It's always in the back of my mind': understanding the psychological impact of recovery following pancreaticoduodenectomy for cancer: a qualitative study..

Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome. (2021)
Journal Article
Riley, R. D., Collins, G. S., Ensor, J., Archer, L., Booth, S., Mozumder, S. I., Rutherford, M. J., van Smeden, M., Lambert, P. C., & Snell, K. I. E. (2022). Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome. Statistics in Medicine, 41(7), 1280-1295. https://doi.org/10.1002/sim.9275

Previous articles in Statistics in Medicine describe how to calculate the sample size required for external validation of prediction models with continuous and binary outcomes. The minimum sample size criteria aim to ensure precise estimation of key... Read More about Minimum sample size calculations for external validation of a clinical prediction model with a time-to-event outcome..

Speculating About Society, Analyzing the Individual: Where Freudian Accounts of Antisemitism Go Wrong (2021)
Journal Article
Kauders, A. (2021). Speculating About Society, Analyzing the Individual: Where Freudian Accounts of Antisemitism Go Wrong. Jahrbuch für Antisemitismusforschung, 47(1), 30-46. https://doi.org/10.1080/14748932.2021.1991615

In January 1847, Branwell Brontë wrote a letter to his friend J. B. Leyland quoting from Lord Byron’s satirical epic Don Juan (1819–24). This was an unusual choice of allusion given that the topic is Byron’s feelings of longsuffering that Branwell us... Read More about Speculating About Society, Analyzing the Individual: Where Freudian Accounts of Antisemitism Go Wrong.

An Allusion to Don Juan: Reappraising Branwell Bronte's Byronic Self-Fashioning (2021)
Journal Article
Shears, J. (2021). An Allusion to Don Juan: Reappraising Branwell Bronte's Byronic Self-Fashioning. Brontë Studies, 30-46. https://doi.org/10.1080/14748932.2021.1991615

In January 1847, Branwell Brontë wrote a letter to his friend J. B. Leyland quoting from Lord Byron’s satirical epic Don Juan. This was an unusual choice of allusion given that the topic is Byron’s feelings of longsuffering that Branwell usually rela... Read More about An Allusion to Don Juan: Reappraising Branwell Bronte's Byronic Self-Fashioning.

Perturbed Composite Attention Model for Macular Optical Coherence Tomography Image Classification (2021)
Journal Article
Mishra, S. S., Mandal, B., & Puhan, N. B. (2021). Perturbed Composite Attention Model for Macular Optical Coherence Tomography Image Classification. IEEE Transactions on Artificial Intelligence, 3(4), 625-635. https://doi.org/10.1109/tai.2021.3135797

In this article, we propose a deep architecture stemming from a perturbed composite attention mechanism with the following two novel attention modules: Multilevel perturbed spatial attention (MPSA) and multidimension attention (MDA) for macular optic... Read More about Perturbed Composite Attention Model for Macular Optical Coherence Tomography Image Classification.

Ligand isomerism fine-tunes structure and stability in zinc complexes of fused pyrazolopyridines (2021)
Journal Article
Swarbrook, A. M., Weekes, R. J., Goodwin, J. W., & Hawes, C. S. (2022). Ligand isomerism fine-tunes structure and stability in zinc complexes of fused pyrazolopyridines. Dalton Transactions, 51(3), 1056-1069. https://doi.org/10.1039/d1dt04007c

Fused-ring pyrazoles offer a versatile platform for derivitization to give finely tuned and functional ligands in coordination assemblies. Here, we explore the pyrazolo[4,3-b]pyridine (HL1) and pyrazolo[3,4-c]pyridine (HL2) backbones and their N-subs... Read More about Ligand isomerism fine-tunes structure and stability in zinc complexes of fused pyrazolopyridines.

A review of the quality and content of mobile apps to support lifestyle modifications following a transient ischaemic attack or 'minor' stroke (2021)
Journal Article
O'Connor, S. R., Kee, F., Thompson, D. R., Cupples, M. E., Donnelly, M., & Heron, N. (2021). A review of the quality and content of mobile apps to support lifestyle modifications following a transient ischaemic attack or 'minor' stroke. Digital Health, 7, Article ARTN 20552076211065271. https://doi.org/10.1177/20552076211065271

Secondary prevention is recommended to reduce cardiovascular risk after transient ischaemic attack (TIA) or ‘minor’ stroke. Mobile health interventions can provide accessible, cost-effective approaches to address modifiable risk factors, such as phys... Read More about A review of the quality and content of mobile apps to support lifestyle modifications following a transient ischaemic attack or 'minor' stroke.

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021)
Journal Article
de Leon, J., Schoretsanitis, G., Smith, R. L., Molden, E., Solismaa, A., Seppälä, N., Kopeček, M., Švancer, P., Olmos, I., Ricciardi, C., Iglesias-Garcia, C., Iglesias-Alonso, A., Spina, E., Ruan, C.-J., Wang, C.-Y., Wang, G., Tang, Y.-L., Lin, S.-K., Lane, H.-Y., Kim, Y. S., …Marder, S. R. (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry, 55(02), 73-86. https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and... Read More about An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study (2021)
Journal Article
Musgrove, R., Carr, M., Chew-Graham, C., Mughal, F., Kapur, N., Ashcroft, D., & Webb, R. (2021). Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study. British Journal of Psychiatry, 1 - 8. https://doi.org/10.1192/bjp.2021.176

<jats:sec id="S0007125021001768_sec_a1"> <jats:title>Background</jats:title> <jats:p>Evidence for risk of dying by suicide and other causes following discharge from in-patient psychiatric care throughout adulthood is sparse.</jats:p> </jats:sec> <jat... Read More about Suicide and other causes of death among working-age and older adults in the year after discharge from in-patient mental healthcare in England: matched cohort study.