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All Outputs (444)

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England (2025)
Journal Article
Lawton, S. A., Mallen, C., Chew-Graham, C., Kingstone, T., Muller, S., Lewis, S., Bajpai, R., & Helliwell, T. (2025). Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England. BMJ Open, 15(6), 1-7. https://doi.org/10.1136/bmjopen-2024-095040

Objectives To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation.

Design A descriptive cross-sectional study.

Setting 10 general practice... Read More about Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa (2025)
Journal Article
Babatunde, O., Adetunji, O., Alonge, I., Owoyemi, T., Ayinmode, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., & Dziedzic, K. (2025). Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa. BMJ Global Health, https://doi.org/10.1136/bmjgh-2024-018714

Objectives: To assess the feasibility of a guideline-informed model of care for osteoarthritis in primary healthcare and community pharmacy settings in West-African context.

Methods: 4-phase mixed-methods programme of research undertaken in south-... Read More about Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa.

Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study (2025)
Journal Article
Hamad, N., Muller, S., Hider, S., Partington, R., Helliwell, T., Butt, H., Hay, C., & Mallen, C. (2025). Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, 1-19. https://doi.org/10.1093/rap/rkaf060

Objectives
To investigate the anatomical locations of pain and stiffness in people with polymyalgia rheumatica (PMR) and how it compares to the general population.

Methods
739 people with PMR were invited to complete a postal survey at the time... Read More about Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives (2025)
Journal Article
Franklin, L., Mallen, C., & Twohig, H. (in press). Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives. British Journal of General Practice Open (BJGP Open), 1-17. https://doi.org/10.3399/BJGPO.2024.0208

Background
Prescribing of pressurised metered dose inhalers (pMDIs) is a key NHS carbon hotspot and reducing the number of these devices prescribed will help achieve NHS net zero targets.

Aim
To explore primary healthcare professionals’ perspe... Read More about Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives.

Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review (2025)
Journal Article
Lovatt, S., Chowdury, N., Mallen, C., & Cooke, A. (2025). Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review. British Journal of Cardiac Nursing, 20(3), 1-16. https://doi.org/10.12968/bjca.2024.0028

Myocardial infarction is a major cause of mortality and morbidity, with smoking being a major risk factor. However, a large proportion of patients continue to smoke following a myocardial infarction, suggesting that there are significant barriers to... Read More about Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review.

Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer (2025)
Journal Article
Dafaalla, M., Walter Dhillon Shanmuganathan, J., Wijeysundera, H. C., Roberts, D. J., Khan, S. U., Elbadawi, A., Elgendy, I. Y., Freeman, P., Mallen, C., & Mamas, M. A. (in press). Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcaf004

Background While current evidence suggests that the clinical outcomes of ST-elevation myocardial infarction (STEMI) are worse among patients with cancer, it is unknown what role the quality of care received during admission plays. We aimed to evaluat... Read More about Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer.

30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. (2025)
Journal Article
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C. D., & Mamas, M. A. (2025). 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. Hellenic Journal of Cardiology, https://doi.org/10.1016/j.hjc.2025.01.006

Introduction
This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with 30-day unplanned readmission rates and causes in patients with acut... Read More about 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score..

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (2025). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink (2025)
Journal Article
Abhishek, A., Nakafero, G., Card, T., Taal, M. W., Grainge, M. J., Aithal, G. P., Mallen, C. D., Stevenson, M. D., & Riley, R. D. (2025). Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink. BMJ Open Gastroenterology, 12(1), https://doi.org/10.1136/bmjgast-2024-001627

Objective: To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. Methods: This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for model deve... Read More about Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink.

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study (2024)
Journal Article
Bullock, L., Holden, M. A., Jinks, C., Atiah Asamane, E., Herron, D., Borrelli, B., Callaghan, M. J., Birrell, F., Halliday, N., Marshall, M., Sowden, G., Ingram, C., McBeth, J., Dziedzic, K., Foster, N. E., Jowett, S., Lawton, S., Mallen, C. D., & Peat, G. (2024). Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study. Musculoskeletal Care, 22(4), Article e70021. https://doi.org/10.1002/msc.70021

Objectives: To explore physiotherapists' experiences and perceived acceptability of delivering a bracing intervention for knee osteoarthritis (OA) in the ‘PROvision of braces for Patients with knee OA’ (PROP OA) randomised controlled trial. Method: S... Read More about Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study.

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., Jordan, K. P., & Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. (2024)
Journal Article
Owoyemi, T., Alonge, I., Adetunji, O., Ogbu, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., Babatunde, O. O., & Dziedzic, K. (2025). Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. Osteoarthritis and Cartilage Open, 7(1), Article 100555. https://doi.org/10.1016/j.ocarto.2024.100555

Objective
Africa contributes significantly to the increasing global prevalence (>37%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA... Read More about Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria..