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Developing an electronic Surprise Question to predict end-of-life prognosis in a prospective cohort study of acute hospital admissions (2025)
Journal Article
SINGH, B., KUMARI-DEWAT, N., RYDER, A., KLAIRE, V., JENNENS, H., AHMED, K., …PARRY, E. (2025). Developing an electronic Surprise Question to predict end-of-life prognosis in a prospective cohort study of acute hospital admissions. Clinical Medicine, Article 100292. https://doi.org/10.1016/j.clinme.2025.100292

Objective
Determining the accuracy of a method calculating the Gold Standards Framework Surprise Question (GSFSQ) equivalent end-of-life prognosis amongst hospital inpatients.
Design
A prospective cohort study with regression calculated 1-year mor... Read More about Developing an electronic Surprise Question to predict end-of-life prognosis in a prospective cohort study of acute hospital admissions.

30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. (2025)
Journal Article
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C. D., & Mamas, M. A. (2025). 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. Hellenic Journal of Cardiology, https://doi.org/10.1016/j.hjc.2025.01.006

Introduction
This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with 30-day unplanned readmission rates and causes in patients with acut... Read More about 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score..

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (2025). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper (2025)
Journal Article
Joury, E., Nakhleh, E., Beveridge, E., Tracy, D., Heidari, E., Shiers, D., …Bhui, K. (in press). Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper. Frontiers in Psychiatry, 15, https://doi.org/10.3389/fpsyt.2024.1426054

Background: Clustering mental, physical and oral conditions reduce drastically the life expectancy. These conditions are precipitated and perpetuated by adverse social, economic, environmental, political and healthcare contextual factors, and sustain... Read More about Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper.

Process evaluation of the BASIL+ trial: A behavioural activation approach to addressing low mood and depression among older people with long-term conditions (2025)
Journal Article
Newbronner, E., Bosanquet, K., Coventry, P., Shearsmith, L., Littlewood, E., Bailey, D., …Chew-Graham, C. (in press). Process evaluation of the BASIL+ trial: A behavioural activation approach to addressing low mood and depression among older people with long-term conditions. PLOS Mental Health, 2(1), 1-15. https://doi.org/10.1371/journal.pmen.0000105

Older adults are at risk of low mood and depression, which can be exacerbated by long-term physical health conditions, leading to poorer health outcomes and increased mortality. The restrictions on social mixing during the COVID-19 pandemic heightene... Read More about Process evaluation of the BASIL+ trial: A behavioural activation approach to addressing low mood and depression among older people with long-term conditions.

An application of matching algorithms to generalize small-area estimates of chronic pain prevalence to neighbourhoods across England (2025)
Journal Article
Quinn, L., Yu, D., Lynch, M., P Jordan, K., Wilkie, R., & Peat, G. (2025). An application of matching algorithms to generalize small-area estimates of chronic pain prevalence to neighbourhoods across England. Journal of Public Health, 1-9. https://doi.org/10.1093/pubmed/fdaf002

Background
Local decision-makers lack granular data on the prevalence of chronic pain in their populations. We applied matching methods to generalize estimates from one local survey in England to other neighborhoods across the country with a similar... Read More about An application of matching algorithms to generalize small-area estimates of chronic pain prevalence to neighbourhoods across England.

Mortality in adolescents after therapeutic intervention for self‐harm: A systematic review and meta‐analysis (2025)
Journal Article
Mughal, F., Young, P., Stahl, D., Asarnow, J. R., & Ougrin, D. (in press). Mortality in adolescents after therapeutic intervention for self‐harm: A systematic review and meta‐analysis. JCPP Advances, Article e12302. https://doi.org/10.1002/jcv2.12302

Background: Self‐harm in adolescents is an international concern. Evidence highlights that therapeutic intervention (TI), such as cognitive behaviour therapy informed treatments, after self‐harm leads to reduced self‐harm repetition. However, there i... Read More about Mortality in adolescents after therapeutic intervention for self‐harm: A systematic review and meta‐analysis.

Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) (2025)
Journal Article
Milewski, M., Desperak, A., Koźlik, M., Bujak, M., Gierlotka, M., Milewski, K., …Gasior, P. (in press). Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA). Scientific Reports, 15(1), 1-11. https://doi.org/10.1038/s41598-025-87121-5

Myocardial infarction with nonobstructive coronary arteries (MINOCA) constitutes 3–15% of all acute myocardial infarctions. Women are more frequently diagnosed with MINOCA, although the influence of sex on long-term outcomes is still unclear. In this... Read More about Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA).

Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization (2025)
Journal Article
Averbuch, T., Zafari, A., Islam, S., Lee, S. F., Sankaranarayanan, R., Greene, S. J., …Van Spall, H. G. (in press). Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization. ESC Heart Failure, 1-10. https://doi.org/10.1002/ehf2.15129

Aims: Risk prediction indices used in worsening heart failure (HF) vary in complexity, performance, and the type of datasets in which they were validated. We compared the performance of seven risk prediction indices in a contemporary cohort of patien... Read More about Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization.

A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research [version 1; peer review: awaiting peer review] (2025)
Journal Article
Ranjbar, J., M. Gibbins, J., Roe, J., Roach, P., Yang, Y., & G.S. Harper, A. (2025). A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research [version 1; peer review: awaiting peer review]. F1000Research, 1-38. https://doi.org/10.12688/f1000research.158910.1

The study of in vivo thrombus formation has principally been performed using intravital microscopy in mice and other species. These have allowed us to visualise the molecular and cellular processes that regulate thrombus formation inside the body. Ho... Read More about A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research [version 1; peer review: awaiting peer review].

Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared with usual care: results from a pragmatic randomised controlled trial (2025)
Journal Article
Wang, H.-I., Gilbody, S., Littlewood, E., Baird, K., Ekers, D., McMillan, D., …Parrott, S. (2025). Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared with usual care: results from a pragmatic randomised controlled trial. BMJ Mental Health, 28(1), 1-9. https://doi.org/10.1136/bmjment-2024-301270

Background: Depression alongside multiple long-term conditions (MLTCs) in older adults poses a critical public health challenge, worsening physical and mental health and increasing healthcare costs. COVID-19 restrictions further exacerbated these imp... Read More about Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared with usual care: results from a pragmatic randomised controlled trial.

The association between physician sex and patient outcomes: a systematic review and meta-analysis (2025)
Journal Article
Heybati, K., Chang, A., Mohamud, H., Satkunasivam, R., Coburn, N., Salles, A., …Wallis, C. J. D. (in press). The association between physician sex and patient outcomes: a systematic review and meta-analysis. BMC Health Services Research, 25(1), Article 93. https://doi.org/10.1186/s12913-025-12247-1

Background: Some prior studies have found that patients treated by female physicians may experience better outcomes, as well as lower healthcare costs than those treated by male physicians. Physician–patient sex concordance may also contribute to bet... Read More about The association between physician sex and patient outcomes: a systematic review and meta-analysis.

The impact of specialist cardiology inpatient care on the long-term outcomes of non-ST-segment elevation myocardial infarction (NSTEMI): A nationwide cohort study. (2025)
Journal Article
Moledina, S. M., Weight, N., Cole, A., Rashid, M., Kontopantelis, E., & Mamas, M. A. (in press). The impact of specialist cardiology inpatient care on the long-term outcomes of non-ST-segment elevation myocardial infarction (NSTEMI): A nationwide cohort study. International Journal of Cardiology, 423, 1-10. https://doi.org/10.1016/j.ijcard.2025.132990

Specialist cardiac care has been shown to reduce inpatient mortality following non-ST segment myocardial infarction (NSTEMI), but whether this benefit extends beyond index admission is unclear. Using the linked Myocardial Ischaemia National Audit Pro... Read More about The impact of specialist cardiology inpatient care on the long-term outcomes of non-ST-segment elevation myocardial infarction (NSTEMI): A nationwide cohort study..

Development of a country-specific food composition database for Sri Lanka (2025)
Journal Article
Opatha, J., Dissanayake, L., Herath, B., Jayaweera, K., Wijesinghe, H., Wijesinghe, H., …Jayawardena, R. (2025). Development of a country-specific food composition database for Sri Lanka. Journal of Food Composition and Analysis, 140, Article 107230. https://doi.org/10.1016/j.jfca.2025.107230

Country-specific Food Composition Data (FCD) could support nutritional research, and aid in making informed decisions to develop food and nutrition policies in a country. Sri Lanka is ethnically diverse, and its food culture and tre... Read More about Development of a country-specific food composition database for Sri Lanka.

Managing thyroid hormone replacement after total thyroidectomy: Guidance for family medicine (2025)
Journal Article
Ahmad, A., Mughal, Z., Jangan, A., Diakos, E., Minhas, S., & Mughal, F. (in press). Managing thyroid hormone replacement after total thyroidectomy: Guidance for family medicine. Journal of Family Medicine and Primary Care, 14(1), 4-7. https://doi.org/10.4103/jfmpc.jfmpc_947_24

Thyroid hormones are among the most prescribed medications to patients worldwide and are commonly used to treat hypothyroidism. Thyroxine is also indicated after total thyroidectomy for Graves’ disease or a multinodular goitre. In this commentary, we... Read More about Managing thyroid hormone replacement after total thyroidectomy: Guidance for family medicine.

A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. (2025)
Journal Article
Wiseman, J., Basit, R. H., Suto, A., Middya, S., Kabiri, B., Evans, M., …Chari, D. M. (in press). A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. Neural Regeneration Research, 20(12), 3539-3552. https://doi.org/10.4103/NRR.NRR-D-24-00422

Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies. Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of t... Read More about A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts..

Age and biologic survival in patients with moderate-to-severe psoriasis: A cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) (2025)
Journal Article
Alabas, O., Mason, K. J., Barker, J., Morrison, S., Yiu, Z., Bewley, A., …Zietemann, V. (2025). Age and biologic survival in patients with moderate-to-severe psoriasis: A cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). British Journal of Dermatology, https://doi.org/10.1093/bjd/ljaf017

The current management of psoriasis does not differentiate between young and old patients in selecting the safest and/or most effective biologic. To explore the effect of age at treatment initiation in response to biologics in patients with moderate-... Read More about Age and biologic survival in patients with moderate-to-severe psoriasis: A cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).