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The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2 (2020)
Thesis
Benn, E. E. (2020). The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2. (Thesis). Keele University

The negative ways in which diabetes affects the brain, and the role of neural insulin and glucose is an interesting research topic as research has shown a correlation between neurodegenerative diseases and diabetes. This thesis focuses on how polyuns... Read More about The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2.

Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs (2020)
Thesis
Whitley, S. O. (2020). Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs. (Thesis). Keele University

Arc magmas typically show distinct geochemical and petrographical evidence indicating a complex petrogenesis. The surface products represent a summation of the complex interplay of geodynamic magma generation processes, varied differentiation histori... Read More about Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs.

FTIR study of zeolites: the nature, concentration and accessibility of the acid sites (2020)
Thesis
Antunes da Silva Freitas, C. M. (2020). FTIR study of zeolites: the nature, concentration and accessibility of the acid sites. (Thesis). Keele University

Zeolites represent one of the most important groups of industrial heterogeneous catalysts with large-scale applications in refining, petrochemistry and increasing potential in environmental catalysis and synthesis of fine chemicals. This broad range... Read More about FTIR study of zeolites: the nature, concentration and accessibility of the acid sites.

Psychological needs and support following stoma surgery: exploring the perspectives of young adults and healthcare professionals (2020)
Thesis
Polidano, K. (2020). Psychological needs and support following stoma surgery: exploring the perspectives of young adults and healthcare professionals. (Thesis). Keele University

Stoma surgery is commonly described as a life-changing procedure, due to the radical bodily changes and related psychosocial challenges it brings about; especially so for individuals with Inflammatory Bowel Disease (IBD) who may undergo this surgery... Read More about Psychological needs and support following stoma surgery: exploring the perspectives of young adults and healthcare professionals.

Pre-main-sequence populations and young stellar variability in the Large Magellanic Cloud (2020)
Thesis
Zivkov, V. (2020). Pre-main-sequence populations and young stellar variability in the Large Magellanic Cloud. (Thesis). Keele University

Detailed studies of intermediate- and low-mass pre-main-sequence (PMS) stars outside the Galaxy have so far been conducted only for small targeted regions harbouring known star formation complexes. This work presents a comprehensive analysis of the P... Read More about Pre-main-sequence populations and young stellar variability in the Large Magellanic Cloud.

Beyond the Five Towns: a re-evaluation of Arnold Bennett (2020)
Thesis
Scragg, H. L. (2020). Beyond the Five Towns: a re-evaluation of Arnold Bennett. (Thesis). Keele University

‘I have a great deal to say, and I mean to say it. As for my work being taken seriously, we shall see about that’. Arnold Bennett, 1909 (Bennett, letter to Pinker dated 17 May 1909, in Letters, Vol. I, p. 123.) Arnold Bennett occupies a somewha... Read More about Beyond the Five Towns: a re-evaluation of Arnold Bennett.

Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core (2020)
Thesis
Jihad, T. W. J. (2020). Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core. (Thesis). Keele University

Calix[4]resorcinarenes functionalised with glycosidic ligands on their lower rim have received little interest compared to analogues bearing carbohydrates on the upper rim. In this study, series of novel macrocyclic glycoclusters bearing mono- or dis... Read More about Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core.

Pain in community-dwelling people with dementia: a mixed methods study (2020)
Thesis
Bullock, L. (2020). Pain in community-dwelling people with dementia: a mixed methods study. (Thesis). Keele University

Introduction Dementia and pain are common in older adults. Clinical features of dementia such as communication difficulties may complicate the identification, assessment, and management of pain. This thesis therefore aimed to investigate pain ident... Read More about Pain in community-dwelling people with dementia: a mixed methods study.

The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells (2020)
Thesis
Mohammed, S. N. (2020). The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells. (Thesis). Keele University

Background and aims: Aggressiveness and invasiveness of breast cancer are influenced by multiple cellular and molecular factors, some of which are yet to be elucidated. In normal cells, vacuolar H (+) -ATPase (V ATPases), which pump protons across th... Read More about The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells.

The coalition government and liberal intervention: Britain’s response to the crises in Libya and Syria (2020)
Thesis
Morgan, P. W. (2020). The coalition government and liberal intervention: Britain’s response to the crises in Libya and Syria. (Thesis). Keele University

This thesis is a study of the response of the Coalition government (2010-2015) to the crises in Libya and Syria. It examines the key drivers of British policy in both cases, focusing particularly on government attitudes towards the use and non-use of... Read More about The coalition government and liberal intervention: Britain’s response to the crises in Libya and Syria.

Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease (2020)
Thesis
Gómez Gálvez, Y. (2020). Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease. (Thesis). Keele University

The degeneration of dopaminergic neurons (DAn) in the midbrain substantia nigra pars compacta (SNpc) is a definitive feature of Parkinson's disease (PD). Although age has been established as one of the main risk factors, the role that ageing has in t... Read More about Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease.

Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study (2020)
Thesis
Ismail, N. (2020). Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study. (Thesis). Keele University

The management of acute coronary syndrome (ACS) with antithrombotic medication achieves the desired goal of reducing the risk of future ischaemic events. However, these reductions are accompanied by increased risk of bleeding complications. A systema... Read More about Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study.

The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique (2020)
Thesis
Alrumuh, A. K. (2020). The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique. (Thesis). Keele University

Background Some respiratory diseases are believed to start early in life, yet manifest later as lung damage progresses. Early pathological changes are usually missed on traditional methods of lung function assessment. Therefore, multiple breath was... Read More about The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique.

Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model (2020)
Thesis
Whittle, E. L. (2020). Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model. (Thesis). Keele University

Asthma is one of the most common chronic diseases of the 21st century, affecting over 300 million people worldwide 1. It is an inflammatory disorder of the airways that is a major public concern globally due to increasing prevalence and rates of mort... Read More about Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model.

Exploring student victimisation and wellbeing in the UK higher education context (2020)
Thesis
Harrison, E. D. (2020). Exploring student victimisation and wellbeing in the UK higher education context. (Thesis). Keele University

Research into student bullying in Higher Education (HE) has been limited and most is based on childhood bullying research. Bullying in HE could disrupt student mental health and wellbeing at university - a topic that has recently gained traction. Add... Read More about Exploring student victimisation and wellbeing in the UK higher education context.

An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering (2020)
Thesis
Foster, N. C. (2020). An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering. (Thesis). Keele University

Articular cartilage is prone to degradation as a result of aging, disease and injury, which can lead to the onset of osteoarthritis (OA). The avascular nature of the tissue renders its endogenous repair capacity notoriously poor and its aneural natur... Read More about An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering.

From research to primary care: a knowledge mobilisation study in osteoarthritis (2020)
Thesis
Swaithes, L. R. (2020). From research to primary care: a knowledge mobilisation study in osteoarthritis. (Thesis). Keele University

Background Osteoarthritis (OA) is the most common long-term condition in primary care and is one of the most frequent causes of pain, loss of function and disability. Research evidence alone does not always lead to changes in practice that benefit p... Read More about From research to primary care: a knowledge mobilisation study in osteoarthritis.

Agrippa's trilemma: scepticism and contemporary epistemology (2020)
Thesis
Burns, A. S. (2020). Agrippa's trilemma: scepticism and contemporary epistemology. (Thesis). Keele University

Take any belief of yours – even one about which you feel supremely confident. The Sceptic will ask: why do you think it is true? You might take yourself to have a very good reason to believe what you do. But the sceptic will also want to know why you... Read More about Agrippa's trilemma: scepticism and contemporary epistemology.

Dynamic chirality and failure in structured materials with applications (2020)
Thesis
Garau, M. (2020). Dynamic chirality and failure in structured materials with applications. (Thesis). Keele University

We consider the vibration of two classes of discrete periodic systems and the resulting dynamic effects. We analyse elastic lattices connected to arrays of gyroscopic spinners, that confer chirality to the elastic system. It is shown in the time-harm... Read More about Dynamic chirality and failure in structured materials with applications.