All Outputs (67)

Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study (2021)
Thesis
Barnett, L. A. (2021). Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study. (Thesis). Keele University

Background: Giant cell arteritis (GCA) is the most common form of medium and large vessel vasculitis. This condition is associated with serious complications, such as blindness if left untreated, and is therefore considered a medical emergency. Howev... Read More about Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study.

Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies (2021)
Thesis
Mogas Barcons, A. (2021). Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies. (Thesis). Keele University

Spinal cord injury is a devastating condition affecting thousands of people every year. The spinal cord does not have the intrinsic capacity for regeneration due to a complex cascade of physical and chemical barriers that prevent axonal growth and le... Read More about Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies.

Kant's 'World': an interpretation of a central idea in the Three Critiques (2021)
Thesis
Orlander, S. O. J. (2021). Kant's 'World': an interpretation of a central idea in the Three Critiques. (Thesis). Keele University

This thesis examines the idea of world in Kant’s Critical philosophy. This is a central idea in the Kantian corpus and plays an important role in different contexts. While interpretations of Kant’s philosophy tend to emphasize the theoretical aspect... Read More about Kant's 'World': an interpretation of a central idea in the Three Critiques.

Structural, stratigraphic and geodynamic controls on the evolution of the Carboniferous succession of northern England and southern Scotland (2021)
Thesis
Howell, L. P. (2021). Structural, stratigraphic and geodynamic controls on the evolution of the Carboniferous succession of northern England and southern Scotland. (Thesis). Keele University

This thesis helps determine some key structural and geodynamic controls on the evolution of Carboniferous basins in northern England and Scotland. One key control on early Carboniferous (rift) basin evolution in northern England is the role of buoyan... Read More about Structural, stratigraphic and geodynamic controls on the evolution of the Carboniferous succession of northern England and southern Scotland.

An integrated analysis of facies control on deformation bands in mixed aeolian-fluvial sandstone reservoirs (2021)
Thesis
Clark, K. (2021). An integrated analysis of facies control on deformation bands in mixed aeolian-fluvial sandstone reservoirs. (Thesis). Keele University

Deformation bands are the primary structural element of fault damage zones within porous granular rocks. They are sub-seismic structures that act to modify the petrophysical properties of the host lithology, and as such are an area of focused researc... Read More about An integrated analysis of facies control on deformation bands in mixed aeolian-fluvial sandstone reservoirs.

Representing Happiness: A comparative study of media coverage of the World Happiness Report (2021)
Thesis
Porto Carreiro Neves, R. (2021). Representing Happiness: A comparative study of media coverage of the World Happiness Report. (Thesis). Keele University

Alongside the rise of positive psychology in late 20th century, happiness has become a topical and heavily debated part of public and academic discourse. Although the concept has been discussed in philosophical terms since antiquity, it is now linked... Read More about Representing Happiness: A comparative study of media coverage of the World Happiness Report.

The impact of principal party strategies on the radical right: In search of a silver bullet? (2021)
Thesis
Mitchell, G. (2021). The impact of principal party strategies on the radical right: In search of a silver bullet?. (Thesis). Keele University

Since the 1980s, many Western European countries have witnessed the rise of the radical right. Much has been written on the ideology of these parties, the tactics they adopt, the sorts of people that vote for them, and the reasons behind their electo... Read More about The impact of principal party strategies on the radical right: In search of a silver bullet?.

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. (2021). Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

The structure and dynamics of the Vela OB2 association (2021)
Thesis
Armstrong, J. (2021). The structure and dynamics of the Vela OB2 association. (Thesis). Keele University

This thesis presents studies of the structure and dynamics of the Vela OB2 association. OB associations are sparse, gravitationally unbound groups of young stars, vital for studying the formation and early evolution of stars and star-forming regions,... Read More about The structure and dynamics of the Vela OB2 association.

Aerobic exercise to improve cardiorespiratory function in Parkinson's (2021)
Thesis
Aburub, A. (2021). Aerobic exercise to improve cardiorespiratory function in Parkinson's. (Thesis). Keele University

Introduction Cardiopulmonary impairments are the leading cause of morbidity and mortality in advanced stages of Parkinson’s. Although there is some evidence of pulmonary impairments in the earlier stages, symptoms remain asymptomatic until advanced... Read More about Aerobic exercise to improve cardiorespiratory function in Parkinson's.

Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study (2021)
Thesis
Chatzixenitidis, A. (2021). Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study. (Thesis). Keele University

Background and aim: Information support is an integral part of cancer care, but its provision can be problematic in busy health settings. The aim of this project was to develop and evaluate a health app to facilitate the provision of information supp... Read More about Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study.

Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice (2021)
Thesis
Lawton, S. A. (2021). Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice. (Thesis). Keele University

Background: There are a range of data collection methodologies employed for collecting patient health related research data. Within primary care settings, and particularly within general practice, time and resources are limited. The utility of an aut... Read More about Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice.

Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells (2021)
Thesis
Fadayomi, I. E. (2021). Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells. (Thesis). Keele University

Ovarian cancer is a gynaecological malignancy associated with the highest level of death. Its resistance against anti-cancer drugs in recent time has exacerbated the problem. Hence, the search for novel drugs from plants used in traditional medicine... Read More about Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells.

An investigation into the biosynthesis of cuticular hydrocarbons in British ants using isotopically labelled diets and gas chromatography - mass spectrometry (2021)
Thesis
Shemilt, S. J. (2021). An investigation into the biosynthesis of cuticular hydrocarbons in British ants using isotopically labelled diets and gas chromatography - mass spectrometry. (Thesis). Keele University

Ants are one of only four groups which can be classed as being truly social, that is they demonstrate altruistic behaviours towards nestmates. However in order to do this there must be a complex nestmate recognition signal at work. This signal is gen... Read More about An investigation into the biosynthesis of cuticular hydrocarbons in British ants using isotopically labelled diets and gas chromatography - mass spectrometry.

Convective boundary structure and mixing in stellar interiors (2021)
Thesis
Scott, L. J. A. (2021). Convective boundary structure and mixing in stellar interiors. (Thesis). Keele University

The treatment of convection remains one of the key uncertainties in stellar evolution. In particular, mixing processes at the boundaries of convective regions are complex and diffcult to define analytically. Therefore, hydrodynamic simulations are us... Read More about Convective boundary structure and mixing in stellar interiors.

The sedimentary architecture and spatial variations of dryland ephemeral fluvial systems (2021)
Thesis
Priddy, C. L. (2021). The sedimentary architecture and spatial variations of dryland ephemeral fluvial systems. (Thesis). Keele University

Ancient dryland continental basins commonly comprise sedimentary fill that records the activity of both fluvial and aeolian environments. Despite extensive studies of dryland ephemeral fluvial systems, detailed three dimensional facies models for the... Read More about The sedimentary architecture and spatial variations of dryland ephemeral fluvial systems.

Magma storage and differentiation in volcanic arcs: examples from the central Aeolian arc, Italy (2021)
Thesis
Wiltshire, R. E. (2021). Magma storage and differentiation in volcanic arcs: examples from the central Aeolian arc, Italy. (Thesis). Keele University

The Aeolian arc is characterised by its complex geodynamic setting, with a heterogeneous mantle source and differing extents of shallow-level magmatic processes. These processes result in large within arc geochemical variations influencing the magma... Read More about Magma storage and differentiation in volcanic arcs: examples from the central Aeolian arc, Italy.

“Partial solutions to the menace”: Philip K. Dick and the Politics of Genre (2021)
Thesis
Johnston Jones, R. D. (2021). “Partial solutions to the menace”: Philip K. Dick and the Politics of Genre. (Thesis). Keele University

In an essay published in 1955, titled ‘Pessimism in Science Fiction’, Philip K. Dick posits that science fiction (sf) cannot function as social critique without conveying a tentative utopian impulse: a “partial solution to the menace”. In the unfoldi... Read More about “Partial solutions to the menace”: Philip K. Dick and the Politics of Genre.

1. Modern English. 2. The regenerating city: space, hauntings and youth culture in the post-millennial Manchester novel (2021)
Thesis
Gufar, S. (2021). 1. Modern English. 2. The regenerating city: space, hauntings and youth culture in the post-millennial Manchester novel. (Thesis). Keele University

My thesis investigates space, hauntings and youth culture in Manchester with two projects: a novel and a critical dissertation. The novel is a coming-of-age story that takes place in Ashton-under-Lyne. Modern English explores the experience of gro... Read More about 1. Modern English. 2. The regenerating city: space, hauntings and youth culture in the post-millennial Manchester novel.