All Outputs (1661)

Physical activity in people with osteoarthritis and comorbidity: a multi-method study (2021)
Thesis
McKevitt, S. (2021). Physical activity in people with osteoarthritis and comorbidity: a multi-method study. (Thesis). Keele University

Osteoarthritis (OA) is common and associated with one of the highest comorbidity rates. OA clinical guidelines recommend physical activity (PA) as core treatment, irrespective of comorbidity. However, no current synthesis of the effectiveness of PA f... Read More about Physical activity in people with osteoarthritis and comorbidity: a multi-method study.

The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning (2021)
Thesis
Fox, J. (2021). The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning. (Thesis). Keele University

This dissertation establishes and defends three positions: (1) The question ‘What is the meaning of life?’ is a request for a global-metaphysical explanation for life and existence that narrates across those elements of most existential import to hum... Read More about The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis
Green, E. L. (2021). Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models. (Thesis). Keele University

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.

Balancing value and effort: a classic grounded theory of frontline police practice (2021)
Thesis
Ash, D. P. (2021). Balancing value and effort: a classic grounded theory of frontline police practice. (Thesis). Keele University

This thesis seeks to explain the behaviour of frontline police officers engaged in incident work. Policymakers try to improve police legitimacy by changing how individual police officers interact with the public at police incidents. However, police p... Read More about Balancing value and effort: a classic grounded theory of frontline police practice.

Investigation into the role of long non-coding RNAs in neuroblastoma and glioma (2021)
Thesis
Bountali, A. (2021). Investigation into the role of long non-coding RNAs in neuroblastoma and glioma. (Thesis). Keele University

Long non-coding RNAs (lncRNAs) play key roles in several processes in healthy and cancer settings and the underpinning mechanisms of their action are thoroughly investigated. In line with this, this study investigates the role of the lncRNA myocardia... Read More about Investigation into the role of long non-coding RNAs in neuroblastoma and glioma.

Exploring the usage of edge gradients within images to perform coarse localisation (2021)
Thesis
Jarvis, D. G. (2021). Exploring the usage of edge gradients within images to perform coarse localisation. (Thesis). Keele University

With the rise in autonomous systems being integrated into the world around us, it has become increasingly important that theses systems have functions that allow the navigation of environments. One of the key functions is the recognition of the envir... Read More about Exploring the usage of edge gradients within images to perform coarse localisation.

Architectural elements in fluvial multi-storey sandbodies: deposition, preservation and numerical representation (2021)
Thesis
Mitten, A. J. (2021). Architectural elements in fluvial multi-storey sandbodies: deposition, preservation and numerical representation. (Thesis). Keele University

The recoverable proportion of known mobile resources from fluvial multi-storey sandbodies (MSBs) reservoirs is relatively low. The low recovery proportion can be attributed to a lack of a three-dimensional understanding of the reservoir architecture,... Read More about Architectural elements in fluvial multi-storey sandbodies: deposition, preservation and numerical representation.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. (2021). Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin (2021)
Thesis
Sampson, E. S. (2021). 1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin. (Thesis). Keele University

The German nineteenth-century fairy-tale has long been, and remains, largely synonymous with the tales of the Brothers Grimm, particularly in the wider public consciousness. While there is some awareness among the general public of other, contemporan... Read More about 1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin.

A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors (2021)
Thesis
Odingo, M. O. (2021). A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors. (Thesis). Keele University

Introduction
A new class of lipid lowering agent Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9) was launched in 2015 for the treatment of heterozygous familial hypercholesterolemia (HeFH) in combination with statin therapy. There a... Read More about A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data (2021)
Thesis
Henry-Blake, C. J. (2021). The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data. (Thesis). Keele University

The National Institute for Health and Care Excellence (NICE) suggests there is no role for routine radiography in the diagnosis of osteoarthritis (OA). It is not known how consistent this recommendation is across guidelines, or the impact of guidelin... Read More about The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data.

Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets (2021)
Thesis
Parker, M. E. (2021). Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets. (Thesis). Keele University

Introduction
Retirement ages are rising in many countries due to population ageing and increasing life expectancy. It is unclear whether people in later working life (age =50) are able to work for longer due to health conditions and a lack of job op... Read More about Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets.

Livelihoods, vulnerability, and adaptation to climate change of small-holder farmers in Kilimanjaro, Tanzania (2021)
Thesis
Mwasha, S. I. (2021). Livelihoods, vulnerability, and adaptation to climate change of small-holder farmers in Kilimanjaro, Tanzania. (Thesis). Keele University

Climate change is expected to reduce food security in many African countries, and yield from rain-fed agriculture is projected to decline significantly. Future warming will persist even if current agreements on emission controls are put into action b... Read More about Livelihoods, vulnerability, and adaptation to climate change of small-holder farmers in Kilimanjaro, Tanzania.

Treaties as a central diplomatic tool in the ‘legal’ pacification, and colonisation of the Western Lower Niger, 1884-1914 (2021)
Thesis
Ariye, E. C. (2021). Treaties as a central diplomatic tool in the ‘legal’ pacification, and colonisation of the Western Lower Niger, 1884-1914. (Thesis). Keele University

This thesis is a case study of Great Britain’s colonisation of a few indigenous, contiguous peoples of the Western Lower Niger from 1884 to 1914. These are the Itsekiri, the Western Ijo, the Urhobo, the Isoko and the Ukwuani of present-day Delta Stat... Read More about Treaties as a central diplomatic tool in the ‘legal’ pacification, and colonisation of the Western Lower Niger, 1884-1914.

4:23 PM, Relaxant (2021)
Thesis
Bolger, L. S. A. (2021). 4:23 PM, Relaxant. (Thesis). Keele University

The practical component of this thesis is a collection of poems entitled 4:23 PM, Relaxant, which consists of an original collection of verse written mainly in the confessional tradition. The collection addresses a number of themes including family a... Read More about 4:23 PM, Relaxant.

The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education (2021)
Thesis
Hay, A. L. (2021). The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education. (Thesis). Keele University

This research investigates two high schools and one middle school in the grip of a seismic policy change as they set aside generations of rivalry to work together as a newly formed Multi-Academy Trust (MAT). It adopts an insider case study approach;... Read More about The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education.

‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa (2021)
Thesis
Spolander, G. C. (2021). ‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa. (Thesis). Keele University

Growing global inequality, austerity and retrogressive social policy (Basu et al., 2017) provide the context for social work practice. The profession is committed to empowering people and addressing social justice, inequality and social cohesion but... Read More about ‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa.

Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D (2021)
Thesis
Williams, H. M. (2021). Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D. (Thesis). Keele University

The surfactant proteins A and D (SP-A and SP-D) and fibrinogen C containing domain 1 (FIBCD1) are pattern recognition receptors, which recognise pathogens through the binding of carbohydrate residues embedded within surface structures. The work prese... Read More about Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D.

Exploring the securitisation of climate change within the meaning of Article 39: mapping the narratives of UN Security Council intervention (2021)
Thesis
Murphy, A. (2021). Exploring the securitisation of climate change within the meaning of Article 39: mapping the narratives of UN Security Council intervention. (Thesis). Keele University

The IPCC is unequivocal that climate change is happening, and its consequences will continue to be devastating for the earth and humanity. The inadequacy of international climate law to mitigate the threat, makes it essential that we search for ways... Read More about Exploring the securitisation of climate change within the meaning of Article 39: mapping the narratives of UN Security Council intervention.

Preparation and structural studies of halogen bonded co-crystals (2021)
Thesis
Mahmood, A. S. M. (2021). Preparation and structural studies of halogen bonded co-crystals. (Thesis). Keele University

The project investigates the reactions of selected aromatic nitrogen compounds with selected di- and interhalogens in order to obtain crystalline N···I halogen-bonded complexes according to the equation:
A + B ? AB

where reactant A is a pyridine... Read More about Preparation and structural studies of halogen bonded co-crystals.