All Outputs (1718)

Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles (2024)
Thesis
Fernando, B. L. Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles. (Thesis). Keele University. https://keele-repository.worktribe.com/output/855660

Introduction
Patients with medically unexplained symptoms (MUS), i.e., physical complaints not fully explained by somatic/psychiatric pathology, are well-documented as a significant problem in primary care. Yet, the issues these patients and their... Read More about Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles.

Crafting self-care practices: learning textile craft in time and space (2024)
Thesis
Fisher, T. E. Crafting self-care practices: learning textile craft in time and space. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849887

This research has been designed to understand how people are crafting time and space to engage with self-care activities through textile crafts. Craft research focuses heavily on the importance of the community and much less on the individuals’ exper... Read More about Crafting self-care practices: learning textile craft in time and space.

Hopf-Galois module structure of some non-normal extensions (2024)
Thesis
Prestidge, G. T. Hopf-Galois module structure of some non-normal extensions. (Thesis). Keele University. https://keele-repository.worktribe.com/output/850279

We use Hopf-Galois theory to study the structure of rings of algebraic integers in some non-normal extensions of number fields which are tamely ramified, generalising results of Del Corso and Rossi for tamely ramified Kummer extensions.

Firstly w... Read More about Hopf-Galois module structure of some non-normal extensions.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

The geometry and distribution of thrust-fold related fractures in limestone (2024)
Thesis
Grodner, M. W. The geometry and distribution of thrust-fold related fractures in limestone. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849840

Outcrop study of fracture geometry and topology in limestones of high-level thrust sheets in the Frontal Himalayan Thrust, north of Islamabad, Pakistan has enabled the determination of convergent tectonic spatial geometries and distributions of thrus... Read More about The geometry and distribution of thrust-fold related fractures in limestone.

Statistical significance of three-dimensional stochastic fluvial reservoir modelling (2024)
Thesis
Davies, C. H. C. Statistical significance of three-dimensional stochastic fluvial reservoir modelling. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849832

Fluvial systems, characterized by complex structures at multiple scales, often serve as excellent reservoirs for both hydrocarbons and carbon storage. Locating such reservoirs, and assessing their quality is challenging due to their sub-seismic natur... Read More about Statistical significance of three-dimensional stochastic fluvial reservoir modelling.

Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy (2024)
Thesis
Çetin, Ö. Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853197

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by the loss-of-function of the survival motor neuron (SMN) gene resulting in muscle atrophy and weakness. There are currently 3 gene-based therapies (Spinraza®, Zolgensma® and Evrysdi®)... Read More about Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy.

A new approach to modelling sources of fluorescent organic matter in Antarctic ice cores (2024)
Thesis
Harris, M. R. P. A new approach to modelling sources of fluorescent organic matter in Antarctic ice cores. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853232

Organic matter trapped within the earth’s ice sheets holds a wide array of potential paleoenvironmental information but remains under-investigated. The fraction that exhibits intrinsic fluorescence, known as fluorescent organic matter (FOM), is broad... Read More about A new approach to modelling sources of fluorescent organic matter in Antarctic ice cores.

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Chemical synthesis approaches to amphiphilic mimetic glycosides (2024)
Thesis
Porter, J. A. Chemical synthesis approaches to amphiphilic mimetic glycosides. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849924

The majority of surfactants in use are derived from petroleum feedstocks. Synthetic surfactants face numerous issues including low biodegradability, ecotoxicity and bioaccumulation. Biosurfactants such as amphiphilic glycoconjugates are a promising c... Read More about Chemical synthesis approaches to amphiphilic mimetic glycosides.

The politics of the UK food sovereignty movement (2024)
Thesis
Westwell, E. The politics of the UK food sovereignty movement. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853518

This thesis explores the political nature of UK Food Sovereignty Movement (UKFSM), focusing predominantly on its expression in England. In doing so this research informs an understanding of what the food sovereignty movement is in the context of the... Read More about The politics of the UK food sovereignty movement.

How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress? (2024)
Thesis
Awan, H. How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849807

People with physical-mental comorbidity have a poorer quality of life, worse clinical outcomes and increased mortality than those with physical conditions alone. Those from some ethnic groups may be less likely to recognise and seek help for symptoms... Read More about How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?.

Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease (2024)
Thesis
Hassan, H. Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849849

Alzheimer's disease (AD) is the most common form of dementia, affecting around 26 million people worldwide, with an expected four-fold increase by 2050. It is characterized by cognitive and mental deficits and is caused by the accumulation of toxic a... Read More about Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease.

An investigation of magnetic nanoparticle mediated methods for neuro-regeneration (2024)
Thesis
Nahar, T. S. An investigation of magnetic nanoparticle mediated methods for neuro-regeneration. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775525

Conditions such as Parkinsons disease, where specific cell types are affected such as the dopaminergic neurons in the substantia nigra pars compacta, cell transplantation and growth factor therapy could restore function and slow disease progression b... Read More about An investigation of magnetic nanoparticle mediated methods for neuro-regeneration.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Exoplanet radius measurements for short-period exoplanets observed by the CHEOPS mission (2024)
Thesis
Harris, B. M. Exoplanet radius measurements for short-period exoplanets observed by the CHEOPS mission. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775271

Context. Scheduling observing time for the CHEOPS mission leaves short gaps in which the telescope goes unused. If data collected during these gaps provided quality results, they could be utilised to make observing time more efficient.
Aims. The ai... Read More about Exoplanet radius measurements for short-period exoplanets observed by the CHEOPS mission.

Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles (2024)
Thesis
Latham-Wheawall, L. Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775441

The need for clean energy is not being met and is increasing each day. One immensely underused technology – proton exchange membrane fuel cells, can drastically help to deliver green energy and prevent the worsening of climate change. However, in ord... Read More about Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles.

The performance and politics of memory-work in contemporary documentary film: transforming violent pasts (2024)
Thesis
Housby, K. E. The performance and politics of memory-work in contemporary documentary film: transforming violent pasts. (Thesis). Keele University. https://keele-repository.worktribe.com/output/674606

This thesis investigates the dynamics of ‘memory-work’ in contemporary documentary films that deal with painful pasts involving violence. The analysis will focus on four recently produced documentary films. Memory-work in this thesis is understood as... Read More about The performance and politics of memory-work in contemporary documentary film: transforming violent pasts.

Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis (2024)
Thesis
Hay, C. A. Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775300

Background: Axial spondyloarthritis (axSpA) causes inflammation of the pelvis and spine, resulting in chronic pain, impaired range of movement, fatigue and physical disability. Diagnosis remains challenging and is frequently delayed, resulting in poo... Read More about Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis.