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All Outputs (1641)

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
(2012). Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.

New forms of hybrid musical discourse; an exploration of stylistic and procedural cross-fertilisation between contemporary art music and electronic dance music
Thesis
(2012). New forms of hybrid musical discourse; an exploration of stylistic and procedural cross-fertilisation between contemporary art music and electronic dance music

This portfolio explores stylistic and procedural cross-fertilisation between contemporary art music and electronic dance music through musicological investigation and creative practice. Comprised of six compositional 'projects', the creative work exa... Read More about New forms of hybrid musical discourse; an exploration of stylistic and procedural cross-fertilisation between contemporary art music and electronic dance music.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
(2012). Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation
Thesis
(2013). Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting approximately 1% of the population. The life expectancy of those with RA is reduced, mainly due to an increased risk of cardiovascular disease (CVD). This thesis investi... Read More about Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation.

The positive predictive value of postmenopausal bleeding for uterine malignancy
Thesis
(2013). The positive predictive value of postmenopausal bleeding for uterine malignancy

Postmenopausal bleeding (PMB) is vaginal bleeding occurring after the menopause. The differing definitions of PMB used and need for a standard definition, including what this might be, are highlighted in the thesis. Benign and malignant causes of PMB... Read More about The positive predictive value of postmenopausal bleeding for uterine malignancy.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
(2012). The influence of the microenvironment on vascularisation of osteochondral tissues

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
(2013). Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

The discovery and characterisation of the extrasolar planets of WASP-South
Thesis
(2013). The discovery and characterisation of the extrasolar planets of WASP-South

SuperWASP is a ground-based survey for transiting extrasolar planets. I present some of my contributions to the project's infrastructure and operations, as well as the discovery and characterisation of seven short-period, giant, transiting extrasolar... Read More about The discovery and characterisation of the extrasolar planets of WASP-South.

The cause and effect of mood disturbance in patients with ankylosing spondylitis
Thesis
(2013). The cause and effect of mood disturbance in patients with ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disorder, causing progressive pain and stiffness of the spine and peripheral joints. A systematic review of the literature revealed a high prevalence of possible depression (23-36%) and possible a... Read More about The cause and effect of mood disturbance in patients with ankylosing spondylitis.

Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations
Thesis
(2013). Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide. Identifying and avoiding disease progression risk factors is important in the management of CKD. Non-Steroidal Anti-inflammatory Drugs (NSAIDs), which are commonly pr... Read More about Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations.

Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection
Thesis
(2013). Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection

Two major components of the common carp Cyprinus carpio innate response, i.e. the C-reactive protein (CRP) and the complement system, have been analysed in common carp either orally immunostimulated with ß-glucan or infected with a pathogen or both.... Read More about Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection.

Trade union responses to civil service restructuring : organising in the Public and Commercial Services union
Thesis
(2013). Trade union responses to civil service restructuring : organising in the Public and Commercial Services union

This thesis explores the adoption of the organising model of union renewal by the Public and Commercial Services union (PCS) in response to membership decline and civil service restructuring. The neoliberal stance of successive UK Governments, togeth... Read More about Trade union responses to civil service restructuring : organising in the Public and Commercial Services union.

The problems and needs of parents with a young mentally handicapped child
Thesis
(1978). The problems and needs of parents with a young mentally handicapped child

Nine personal interviews were conducted with mothers of mentally and physically handicapped children. A postal questionnaire was designed to appraise the problems and needs of parents with a mentally handicapped child aged twelve or under living at h... Read More about The problems and needs of parents with a young mentally handicapped child.

(En)gendering barriers: a comparative discussion of the woman question in mid- to late-nineteenth-century English, German and Russian literatures
Thesis
(2010). (En)gendering barriers: a comparative discussion of the woman question in mid- to late-nineteenth-century English, German and Russian literatures

Imagery of enclosure [...] constantly threatens to stifle the heroines of women’s fiction. This thesis seeks to develop recent research into Russian literature, which has applied semiotic theory to a feminist critique, to explore how spaces may b... Read More about (En)gendering barriers: a comparative discussion of the woman question in mid- to late-nineteenth-century English, German and Russian literatures.

Isolation, purification and characterisation of the pentraxins from Limulus polyphemus and Mustelus canis
Thesis
(2008). Isolation, purification and characterisation of the pentraxins from Limulus polyphemus and Mustelus canis

CRP and SAP form part of the innate immune system in humans, and homologues have been found in mammals, amphibians, fish, elasmobranchs, and invertebrates. The aim of this research was to broaden knowledge of CRP and SAP in horseshoe crabs, and to at... Read More about Isolation, purification and characterisation of the pentraxins from Limulus polyphemus and Mustelus canis.