263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis

Glossop, John R.; Nixon, Nicola B.; Emes, Richard D.; Haworth, Kim E.; Packham, Jon C.; Dawes, Peter T.; Fryer, Anthony A.; Mattey, Derek L.; Farrell, William E.

doi:10.1093/rheumatology/keu122.001

All Outputs (7)

Methylation of the FGFR2 gene is associated with high birth weight centile in humans (2014)
Journal Article

Aims: This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. Materials & methods: Using HumanMethylation450 arrays, we examined candidate gene-associated CpGs in cord blood from... Read More about Methylation of the FGFR2 gene is associated with high birth weight centile in humans.

Measuring vitamin D levels: surrogates are insufficient (2014)
Journal Article

With the increasing evidence of adverse consequences because of low vitamin D levels on health demand for vitamin D, screening is increasing. The objective of the study was to assess whether parathyroid hormone (PTH) levels/bone profile is suffici... Read More about Measuring vitamin D levels: surrogates are insufficient.

Reduced Testing Frequency for Glycated Hemoglobin, HbA(1c), Is Associated With Deteriorating Diabetes Control (2014)
Journal Article

Objective: We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabete... Read More about Reduced Testing Frequency for Glycated Hemoglobin, HbA(1c), Is Associated With Deteriorating Diabetes Control.

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations (2014)
Journal Article

Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMeth... Read More about Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations.

Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine (2014)
Presentation / Conference

Background: Vitamin D is implicated in the expression of childhood asthma but it is difficult to pick apart cause and effect from observational data. If lack of vitamin D is secondary to a sedentary lifestyle then weather patterns should not effect a... Read More about Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine.

Evaluation of accuracy of mediolateral episiotomy incisions using a training model (2014)
Journal Article

Background: Episiotomy is one of the most commonly performed surgical procedures worldwide. In the UK the use of episiotomy is selective, rather than routine, and a right mediolateral episiotomy (RMLE) is considered standard practice. According to Th... Read More about Evaluation of accuracy of mediolateral episiotomy incisions using a training model.

263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis (2014)
Presentation / Conference

Background: DNA methylation is one of several epigenetic mechanisms that impacts on gene expression without underlying changes to the DNA sequence. Recent studies describe changes to the DNA methylome in RA. To date however, no systematic genome-wide... Read More about 263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis.